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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Definitions
- Failed first trimester pregnancy refers to collection of specific diagnoses that are nonviable
- Avoids confusion and simplifies terminology
- Anembryonic pregnancy (AP): Failure of embryo to develop or early demise with resorption of embryonic pole (a.k.a. "blighted ovum," less favored term)
- Embryonic demise (ED): Embryo ≥ 7 mm in length with no heartbeat
- Spontaneous abortion: Involuntary pregnancy loss in 1st 20 weeks; may be inevitable, incomplete, or complete
- Missed abortion: General term for ED or AP; latter terms are more accurate and preferred
- Failed first trimester pregnancy refers to collection of specific diagnoses that are nonviable
IMAGING
General Features
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Doubilet PM: Ultrasound evaluation of the first trimester. Radiol Clin North Am. 52(6):1191-9, 2014
- Doubilet PM et al: Diagnostic criteria for nonviable pregnancy early in the first trimester. N Engl J Med. 369(15):1443-51, 2013
- Lane BF et al: ACR appropriateness Criteria® first trimester bleeding. Ultrasound Q. 29(2):91-6, 2013
- Salamanca A et al: Early embryonic morphology sonographically assessed and its correlation with yolk sac in missed abortion. Arch Gynecol Obstet. 287(1):139-42, 2013
- Abdallah Y et al: Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study. Ultrasound Obstet Gynecol. 38(5):497-502, 2011
- Jeve Y et al: Accuracy of first-trimester ultrasound in the diagnosis of early embryonic demise: a systematic review. Ultrasound Obstet Gynecol. 38(5):489-96, 2011
- Papaioannou GI et al: Ultrasonographic prediction of early miscarriage. Hum Reprod. 26(7):1685-92, 2011
- Tan S et al: Irregular yolk sac shape: is it really associated with an increased risk of spontaneous abortion? J Ultrasound Med. 30(1):31-6, 2011
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Definitions
- Failed first trimester pregnancy refers to collection of specific diagnoses that are nonviable
- Avoids confusion and simplifies terminology
- Anembryonic pregnancy (AP): Failure of embryo to develop or early demise with resorption of embryonic pole (a.k.a. "blighted ovum," less favored term)
- Embryonic demise (ED): Embryo ≥ 7 mm in length with no heartbeat
- Spontaneous abortion: Involuntary pregnancy loss in 1st 20 weeks; may be inevitable, incomplete, or complete
- Missed abortion: General term for ED or AP; latter terms are more accurate and preferred
- Failed first trimester pregnancy refers to collection of specific diagnoses that are nonviable
IMAGING
General Features
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Doubilet PM: Ultrasound evaluation of the first trimester. Radiol Clin North Am. 52(6):1191-9, 2014
- Doubilet PM et al: Diagnostic criteria for nonviable pregnancy early in the first trimester. N Engl J Med. 369(15):1443-51, 2013
- Lane BF et al: ACR appropriateness Criteria® first trimester bleeding. Ultrasound Q. 29(2):91-6, 2013
- Salamanca A et al: Early embryonic morphology sonographically assessed and its correlation with yolk sac in missed abortion. Arch Gynecol Obstet. 287(1):139-42, 2013
- Abdallah Y et al: Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study. Ultrasound Obstet Gynecol. 38(5):497-502, 2011
- Jeve Y et al: Accuracy of first-trimester ultrasound in the diagnosis of early embryonic demise: a systematic review. Ultrasound Obstet Gynecol. 38(5):489-96, 2011
- Papaioannou GI et al: Ultrasonographic prediction of early miscarriage. Hum Reprod. 26(7):1685-92, 2011
- Tan S et al: Irregular yolk sac shape: is it really associated with an increased risk of spontaneous abortion? J Ultrasound Med. 30(1):31-6, 2011
