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Felty Syndrome
Eva M. Escobedo, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Felty syndrome (FS)
          • Definitions

            • Triad of rheumatoid arthritis (RA), splenomegaly, neutropenia
            • Rare development of extraarticular manifestations of neutropenia and splenomegaly in longstanding seropositive RA

          IMAGING

          • General Features

            • CT/MR/US Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              Selected References

                              1. Figus FA et al: Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 20(4):102776, 2021
                              2. Gorodetskiy VR et al: Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis. Rheumatol Int. 41(1):147-56, 2021
                              3. Li R et al: Tocilizumab treatment in Felty's syndrome. Rheumatol Int. 40(7):1143-9, 2020
                              4. Das S et al: An overview of the extraarticular involvement in rheumatoid arthritis and its management. J Pharmacol Pharmacother. 8(3):81-6, 2017
                              5. Godhwani S et al: A case of rheumatoid arthritis with felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases. J Clin Rheumatol. 21(1):53-5, 2015
                              6. Lazaro E et al: Management of neutropenia in patients with rheumatoid arthritis. Joint Bone Spine. 82(4):235-9, 2015
                              7. Bockorny B et al: Autoimmune manifestations in large granular lymphocyte leukemia. Clin Lymphoma Myeloma Leuk. 12(6):400-5, 2012
                              8. Narváez J et al: Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 41(5):658-68, 2012
                              9. Tomi AL et al: One case of Felty's syndrome efficiently treated with rituximab. Joint Bone Spine. 79(6):624-5, 2012
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Abbreviations

                                        • Felty syndrome (FS)
                                      • Definitions

                                        • Triad of rheumatoid arthritis (RA), splenomegaly, neutropenia
                                        • Rare development of extraarticular manifestations of neutropenia and splenomegaly in longstanding seropositive RA

                                      IMAGING

                                      • General Features

                                        • CT/MR/US Findings

                                          • Imaging Recommendations

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • General Features

                                                CLINICAL ISSUES

                                                • Presentation

                                                  • Demographics

                                                    • Natural History & Prognosis

                                                      • Treatment

                                                        DIAGNOSTIC CHECKLIST

                                                        • Consider

                                                          Selected References

                                                          1. Figus FA et al: Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 20(4):102776, 2021
                                                          2. Gorodetskiy VR et al: Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis. Rheumatol Int. 41(1):147-56, 2021
                                                          3. Li R et al: Tocilizumab treatment in Felty's syndrome. Rheumatol Int. 40(7):1143-9, 2020
                                                          4. Das S et al: An overview of the extraarticular involvement in rheumatoid arthritis and its management. J Pharmacol Pharmacother. 8(3):81-6, 2017
                                                          5. Godhwani S et al: A case of rheumatoid arthritis with felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases. J Clin Rheumatol. 21(1):53-5, 2015
                                                          6. Lazaro E et al: Management of neutropenia in patients with rheumatoid arthritis. Joint Bone Spine. 82(4):235-9, 2015
                                                          7. Bockorny B et al: Autoimmune manifestations in large granular lymphocyte leukemia. Clin Lymphoma Myeloma Leuk. 12(6):400-5, 2012
                                                          8. Narváez J et al: Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 41(5):658-68, 2012
                                                          9. Tomi AL et al: One case of Felty's syndrome efficiently treated with rituximab. Joint Bone Spine. 79(6):624-5, 2012