Triad of rheumatoid arthritis (RA), splenomegaly, neutropenia
Rare development of extraarticular manifestations of neutropenia and splenomegaly in longstanding seropositive RA
IMAGING
General Features
CT/MR/US Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Figus FA et al: Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 20(4):102776, 2021
Gorodetskiy VR et al: Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis. Rheumatol Int. 41(1):147-56, 2021
Li R et al: Tocilizumab treatment in Felty's syndrome. Rheumatol Int. 40(7):1143-9, 2020
Das S et al: An overview of the extraarticular involvement in rheumatoid arthritis and its management. J Pharmacol Pharmacother. 8(3):81-6, 2017
Godhwani S et al: A case of rheumatoid arthritis with felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases. J Clin Rheumatol. 21(1):53-5, 2015
Lazaro E et al: Management of neutropenia in patients with rheumatoid arthritis. Joint Bone Spine. 82(4):235-9, 2015
Bockorny B et al: Autoimmune manifestations in large granular lymphocyte leukemia. Clin Lymphoma Myeloma Leuk. 12(6):400-5, 2012
Narváez J et al: Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 41(5):658-68, 2012
Tomi AL et al: One case of Felty's syndrome efficiently treated with rituximab. Joint Bone Spine. 79(6):624-5, 2012
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
Felty syndrome (FS)
Definitions
Triad of rheumatoid arthritis (RA), splenomegaly, neutropenia
Rare development of extraarticular manifestations of neutropenia and splenomegaly in longstanding seropositive RA
IMAGING
General Features
CT/MR/US Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Figus FA et al: Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 20(4):102776, 2021
Gorodetskiy VR et al: Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis. Rheumatol Int. 41(1):147-56, 2021
Li R et al: Tocilizumab treatment in Felty's syndrome. Rheumatol Int. 40(7):1143-9, 2020
Das S et al: An overview of the extraarticular involvement in rheumatoid arthritis and its management. J Pharmacol Pharmacother. 8(3):81-6, 2017
Godhwani S et al: A case of rheumatoid arthritis with felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases. J Clin Rheumatol. 21(1):53-5, 2015
Lazaro E et al: Management of neutropenia in patients with rheumatoid arthritis. Joint Bone Spine. 82(4):235-9, 2015
Bockorny B et al: Autoimmune manifestations in large granular lymphocyte leukemia. Clin Lymphoma Myeloma Leuk. 12(6):400-5, 2012
Narváez J et al: Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 41(5):658-68, 2012
Tomi AL et al: One case of Felty's syndrome efficiently treated with rituximab. Joint Bone Spine. 79(6):624-5, 2012
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