Nicole S. Winkler, MD; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Fibroadenomatoid change (FAC)
Synonyms
Fibroadenomatoid hyperplasia = fibroadenomatosis
Fibroadenomatoid mastopathy
Definitions
Benign stromal hyperplasia compressing and distorting epithelium similar to fibroadenoma (FA), but less organized/defined, involving multiple lobules
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Selected References
Saimura M et al: Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 25(4):470-478, 2018
East EG et al: Clinicopathological findings in female-to-male gender-affirming breast surgery. Histopathology. 71(6):859-865, 2017
Grimm LJ et al: Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors. Eur Radiol. 27(6):2275-2281, 2017
Chen Y et al: Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study. PLoS One. 10(6):e0129500, 2015
Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
Langer SA et al: Pathologic correlates of false positive breast magnetic resonance imaging findings: which lesions warrant biopsy? Am J Surg. 190(4):633-40, 2005
Woodhams R et al: ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci. 4(1):35-42, 2005
Liberman L et al: Ductal enhancement on MR imaging of the breast. AJR Am J Roentgenol. 181(2):519-25, 2003
Kamal M et al: Fibroadenomatoid hyperplasia: a cause of suspicious microcalcification on mammographic screening. AJR Am J Roentgenol. 171(5):1331-4, 1998
Tan PE et al: Fibroadenomatoid mastopathy: another distractive breast lesion? Malays J Pathol. 13(2):101-4, 1991
Nielsen BB: Fibroadenomatoid hyperplasia of the male breast. Am J Surg Pathol. 14(8):774-7, 1990
Hanson CA et al: Fibroadenomatosis (fibroadenomatoid mastopathy): a benign breast lesion with composite pathologic features. Pathology. 19(4):393-6, 1987
Orcel L et al: [Histogenetic study of mammary gland fibro-adenomas] Ann Anat Pathol (Paris). 18(3):255-76, 1973
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Fibroadenomatoid change (FAC)
Synonyms
Fibroadenomatoid hyperplasia = fibroadenomatosis
Fibroadenomatoid mastopathy
Definitions
Benign stromal hyperplasia compressing and distorting epithelium similar to fibroadenoma (FA), but less organized/defined, involving multiple lobules
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Selected References
Saimura M et al: Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 25(4):470-478, 2018
East EG et al: Clinicopathological findings in female-to-male gender-affirming breast surgery. Histopathology. 71(6):859-865, 2017
Grimm LJ et al: Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors. Eur Radiol. 27(6):2275-2281, 2017
Chen Y et al: Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study. PLoS One. 10(6):e0129500, 2015
Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
Langer SA et al: Pathologic correlates of false positive breast magnetic resonance imaging findings: which lesions warrant biopsy? Am J Surg. 190(4):633-40, 2005
Woodhams R et al: ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci. 4(1):35-42, 2005
Liberman L et al: Ductal enhancement on MR imaging of the breast. AJR Am J Roentgenol. 181(2):519-25, 2003
Kamal M et al: Fibroadenomatoid hyperplasia: a cause of suspicious microcalcification on mammographic screening. AJR Am J Roentgenol. 171(5):1331-4, 1998
Tan PE et al: Fibroadenomatoid mastopathy: another distractive breast lesion? Malays J Pathol. 13(2):101-4, 1991
Nielsen BB: Fibroadenomatoid hyperplasia of the male breast. Am J Surg Pathol. 14(8):774-7, 1990
Hanson CA et al: Fibroadenomatosis (fibroadenomatoid mastopathy): a benign breast lesion with composite pathologic features. Pathology. 19(4):393-6, 1987
Orcel L et al: [Histogenetic study of mammary gland fibro-adenomas] Ann Anat Pathol (Paris). 18(3):255-76, 1973
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