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Breast
Histopathologic Diagnoses
Benign Lesions
Fibroadenomatoid Change
Fibroadenomatoid Change
Nicole S. Winkler, MD; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Fibroadenomatoid change (FAC)

            • Synonyms

              • Fibroadenomatoid hyperplasia = fibroadenomatosis
              • Fibroadenomatoid mastopathy

            • Definitions

              • Benign stromal hyperplasia compressing and distorting epithelium similar to fibroadenoma (FA), but less organized/defined, involving multiple lobules

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Demographics

                            • Natural History & Prognosis

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                Selected References

                                1. Saimura M et al: Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 25(4):470-478, 2018
                                2. East EG et al: Clinicopathological findings in female-to-male gender-affirming breast surgery. Histopathology. 71(6):859-865, 2017
                                3. Grimm LJ et al: Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors. Eur Radiol. 27(6):2275-2281, 2017
                                4. Chen Y et al: Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study. PLoS One. 10(6):e0129500, 2015
                                5. Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
                                6. Langer SA et al: Pathologic correlates of false positive breast magnetic resonance imaging findings: which lesions warrant biopsy? Am J Surg. 190(4):633-40, 2005
                                7. Woodhams R et al: ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci. 4(1):35-42, 2005
                                8. Liberman L et al: Ductal enhancement on MR imaging of the breast. AJR Am J Roentgenol. 181(2):519-25, 2003
                                9. Kamal M et al: Fibroadenomatoid hyperplasia: a cause of suspicious microcalcification on mammographic screening. AJR Am J Roentgenol. 171(5):1331-4, 1998
                                10. Tan PE et al: Fibroadenomatoid mastopathy: another distractive breast lesion? Malays J Pathol. 13(2):101-4, 1991
                                11. Nielsen BB: Fibroadenomatoid hyperplasia of the male breast. Am J Surg Pathol. 14(8):774-7, 1990
                                12. Hanson CA et al: Fibroadenomatosis (fibroadenomatoid mastopathy): a benign breast lesion with composite pathologic features. Pathology. 19(4):393-6, 1987
                                13. Orcel L et al: [Histogenetic study of mammary gland fibro-adenomas] Ann Anat Pathol (Paris). 18(3):255-76, 1973
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Fibroadenomatoid change (FAC)

                                          • Synonyms

                                            • Fibroadenomatoid hyperplasia = fibroadenomatosis
                                            • Fibroadenomatoid mastopathy

                                          • Definitions

                                            • Benign stromal hyperplasia compressing and distorting epithelium similar to fibroadenoma (FA), but less organized/defined, involving multiple lobules

                                          IMAGING

                                          • General Features

                                            • Mammographic Findings

                                              • Ultrasonographic Findings

                                                • MR Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              Selected References

                                                              1. Saimura M et al: Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 25(4):470-478, 2018
                                                              2. East EG et al: Clinicopathological findings in female-to-male gender-affirming breast surgery. Histopathology. 71(6):859-865, 2017
                                                              3. Grimm LJ et al: Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors. Eur Radiol. 27(6):2275-2281, 2017
                                                              4. Chen Y et al: Positive Association of Fibroadenomatoid Change with HER2-Negative Invasive Breast Cancer: A Co-Occurrence Study. PLoS One. 10(6):e0129500, 2015
                                                              5. Kim SY et al: Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS. Ann Surg Oncol. 22(9):2895-901, 2015
                                                              6. Langer SA et al: Pathologic correlates of false positive breast magnetic resonance imaging findings: which lesions warrant biopsy? Am J Surg. 190(4):633-40, 2005
                                                              7. Woodhams R et al: ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci. 4(1):35-42, 2005
                                                              8. Liberman L et al: Ductal enhancement on MR imaging of the breast. AJR Am J Roentgenol. 181(2):519-25, 2003
                                                              9. Kamal M et al: Fibroadenomatoid hyperplasia: a cause of suspicious microcalcification on mammographic screening. AJR Am J Roentgenol. 171(5):1331-4, 1998
                                                              10. Tan PE et al: Fibroadenomatoid mastopathy: another distractive breast lesion? Malays J Pathol. 13(2):101-4, 1991
                                                              11. Nielsen BB: Fibroadenomatoid hyperplasia of the male breast. Am J Surg Pathol. 14(8):774-7, 1990
                                                              12. Hanson CA et al: Fibroadenomatosis (fibroadenomatoid mastopathy): a benign breast lesion with composite pathologic features. Pathology. 19(4):393-6, 1987
                                                              13. Orcel L et al: [Histogenetic study of mammary gland fibro-adenomas] Ann Anat Pathol (Paris). 18(3):255-76, 1973