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Musculoskeletal
Diagnosis
Non-Trauma
Congenital and Developmental Abnormalities
General
Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva
Kara G. Gill, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Fibrodysplasia ossificans progressiva (FOP)

          • Synonyms

            • Myositis ossificans progressiva

          • Definitions

            • Hereditary mesodermal disorder resulting in mature ossification within soft tissues, bridging between bones

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Kaplan FS et al: Fibrodysplasia ossificans progressiva (FOP): a disorder of osteochondrogenesis. Bone. 140:115539, 2020
                                  2. Bauer AH et al: Fibrodysplasia ossificans progressiva: a current review of imaging findings. Skeletal Radiol. 47(8):1043-50, 2018
                                  3. Maftei C et al: Fibrodysplasia ossificans progressiva: bilateral hallux valgus on ultrasound a clue for the first prenatal diagnosis for this condition-clinical report and review of the literature. Prenat Diagn. 35(3):305-7, 2015
                                  4. Sharma A et al: Heterotopic ossification in fibrodysplasia ossificans progressiva. J Pediatr. 166(1):204, 2015
                                  5. Martelli A et al: Cellular and morphological aspects of fibrodysplasia ossificans progressiva. Lessons of formation, repair, and bone bioengineering. Organogenesis. 10(3):303-11, 2014
                                  6. Tung CH et al: Fibrodysplasia ossificans progressiva seen on three-dimensional computed tomography. Arthritis Rheum. 58(1):250, 2008
                                  7. Tulchinsky M: Diagnostic features of fibrodysplasia (myositis) ossificans progressiva on bone scan. Clin Nucl Med. 32(8):616-9, 2007
                                  8. Merchant R et al: Pre- and post-therapy MR imaging in fibrodysplasia ossificans progressiva. Pediatr Radiol. 36(10):1108-11, 2006
                                  9. McCarthy EF et al: Heterotopic ossification: a review. Skeletal Radiol. 34(10):609-19, 2005
                                  10. Trikha V et al: Characteristic appearance on bone scintigraphy of a 'stone man'. Clin Nucl Med. 30(7):517-8, 2005
                                  11. Ben Hamida KS et al: Myositis ossificans circumscripta of the knee improved by alendronate. Joint Bone Spine. 71(2):144-6, 2004
                                  12. Hagiwara H et al: Contrast-enhanced MRI of an early preosseous lesion of fibrodysplasia ossificans progressiva in a 21-month-old boy. AJR Am J Roentgenol. 181(4):1145-7, 2003
                                  13. Akesson LS et al: Fibrodysplasia Ossificans Progressiva 1993
                                  14. Reinig JW et al: Fibrodysplasia ossificans progressiva: CT appearance. Radiology. 159(1):153-7, 1986
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Fibrodysplasia ossificans progressiva (FOP)

                                          • Synonyms

                                            • Myositis ossificans progressiva

                                          • Definitions

                                            • Hereditary mesodermal disorder resulting in mature ossification within soft tissues, bridging between bones

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • CT Findings

                                                • MR Findings

                                                  • Ultrasonographic Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Kaplan FS et al: Fibrodysplasia ossificans progressiva (FOP): a disorder of osteochondrogenesis. Bone. 140:115539, 2020
                                                                  2. Bauer AH et al: Fibrodysplasia ossificans progressiva: a current review of imaging findings. Skeletal Radiol. 47(8):1043-50, 2018
                                                                  3. Maftei C et al: Fibrodysplasia ossificans progressiva: bilateral hallux valgus on ultrasound a clue for the first prenatal diagnosis for this condition-clinical report and review of the literature. Prenat Diagn. 35(3):305-7, 2015
                                                                  4. Sharma A et al: Heterotopic ossification in fibrodysplasia ossificans progressiva. J Pediatr. 166(1):204, 2015
                                                                  5. Martelli A et al: Cellular and morphological aspects of fibrodysplasia ossificans progressiva. Lessons of formation, repair, and bone bioengineering. Organogenesis. 10(3):303-11, 2014
                                                                  6. Tung CH et al: Fibrodysplasia ossificans progressiva seen on three-dimensional computed tomography. Arthritis Rheum. 58(1):250, 2008
                                                                  7. Tulchinsky M: Diagnostic features of fibrodysplasia (myositis) ossificans progressiva on bone scan. Clin Nucl Med. 32(8):616-9, 2007
                                                                  8. Merchant R et al: Pre- and post-therapy MR imaging in fibrodysplasia ossificans progressiva. Pediatr Radiol. 36(10):1108-11, 2006
                                                                  9. McCarthy EF et al: Heterotopic ossification: a review. Skeletal Radiol. 34(10):609-19, 2005
                                                                  10. Trikha V et al: Characteristic appearance on bone scintigraphy of a 'stone man'. Clin Nucl Med. 30(7):517-8, 2005
                                                                  11. Ben Hamida KS et al: Myositis ossificans circumscripta of the knee improved by alendronate. Joint Bone Spine. 71(2):144-6, 2004
                                                                  12. Hagiwara H et al: Contrast-enhanced MRI of an early preosseous lesion of fibrodysplasia ossificans progressiva in a 21-month-old boy. AJR Am J Roentgenol. 181(4):1145-7, 2003
                                                                  13. Akesson LS et al: Fibrodysplasia Ossificans Progressiva 1993
                                                                  14. Reinig JW et al: Fibrodysplasia ossificans progressiva: CT appearance. Radiology. 159(1):153-7, 1986