Distinct clinical, histopathologic, and imaging features differentiate it from conventional HCC
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
Ramai D et al: Fibrolamellar hepatocellular carcinoma: a population-based observational study. Dig Dis Sci. 66(1):308-14, 2021
Dong Y et al: Imaging features of fibrolamellar hepatocellular carcinoma with contrast-enhanced ultrasound. Ultraschall Med. ePub, 2020
Graham RP: Fibrolamellar carcinoma: what is new and why it matters. Surg Pathol Clin. 11(2):377-87, 2018
Palm V et al: Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI. Cancer Imaging. 18(1):9, 2018
Lafaro KJ et al: Fibrolamellar hepatocellular carcinoma: current clinical perspectives. J Hepatocell Carcinoma. 2:151-7, 2015
Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Fibrolamellar carcinoma (FLC) of liver
Synonyms
Fibrolamellar hepatocellular carcinoma (HCC)
Definitions
Uncommon, malignant hepatocellular tumor
Distinct clinical, histopathologic, and imaging features differentiate it from conventional HCC
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
Ramai D et al: Fibrolamellar hepatocellular carcinoma: a population-based observational study. Dig Dis Sci. 66(1):308-14, 2021
Dong Y et al: Imaging features of fibrolamellar hepatocellular carcinoma with contrast-enhanced ultrasound. Ultraschall Med. ePub, 2020
Graham RP: Fibrolamellar carcinoma: what is new and why it matters. Surg Pathol Clin. 11(2):377-87, 2018
Palm V et al: Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI. Cancer Imaging. 18(1):9, 2018
Lafaro KJ et al: Fibrolamellar hepatocellular carcinoma: current clinical perspectives. J Hepatocell Carcinoma. 2:151-7, 2015
Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995
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