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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Fibrolamellar carcinoma (FLC) of liver
Synonyms
- Fibrolamellar hepatocellular carcinoma (HCC)
Definitions
- Uncommon, malignant hepatocellular tumor
- Distinct clinical, histopathologic, and imaging features differentiate it from conventional HCC
- Uncommon, malignant hepatocellular tumor
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
- Ramai D et al: Fibrolamellar hepatocellular carcinoma: a population-based observational study. Dig Dis Sci. 66(1):308-14, 2021
- Dong Y et al: Imaging features of fibrolamellar hepatocellular carcinoma with contrast-enhanced ultrasound. Ultraschall Med. ePub, 2020
- Graham RP: Fibrolamellar carcinoma: what is new and why it matters. Surg Pathol Clin. 11(2):377-87, 2018
- Palm V et al: Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI. Cancer Imaging. 18(1):9, 2018
- Lafaro KJ et al: Fibrolamellar hepatocellular carcinoma: current clinical perspectives. J Hepatocell Carcinoma. 2:151-7, 2015
- Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
- Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
- Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
- Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
- Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
- Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
- Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
- Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
- Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
- McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
- Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
- Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Fibrolamellar carcinoma (FLC) of liver
Synonyms
- Fibrolamellar hepatocellular carcinoma (HCC)
Definitions
- Uncommon, malignant hepatocellular tumor
- Distinct clinical, histopathologic, and imaging features differentiate it from conventional HCC
- Uncommon, malignant hepatocellular tumor
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Gigante E et al: New insights into the pathophysiology and clinical care of rare primary liver cancers. JHEP Rep. 3(1):100174, 2021
- Ramai D et al: Fibrolamellar hepatocellular carcinoma: a population-based observational study. Dig Dis Sci. 66(1):308-14, 2021
- Dong Y et al: Imaging features of fibrolamellar hepatocellular carcinoma with contrast-enhanced ultrasound. Ultraschall Med. ePub, 2020
- Graham RP: Fibrolamellar carcinoma: what is new and why it matters. Surg Pathol Clin. 11(2):377-87, 2018
- Palm V et al: Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI. Cancer Imaging. 18(1):9, 2018
- Lafaro KJ et al: Fibrolamellar hepatocellular carcinoma: current clinical perspectives. J Hepatocell Carcinoma. 2:151-7, 2015
- Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
- Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
- Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
- Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
- Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
- Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
- Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
- Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
- Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
- McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
- Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
- Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995
