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Fibrolamellar Carcinoma
Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Fibrolamellar carcinoma (FLC) of liver
          • Synonyms

            • Fibrolamellar hepatocellular carcinoma
          • Definitions

            • Uncommon malignant hepatocellular tumor
              • Distinct clinical, histopathologic, and imaging features differentiate it from conventional hepatocellular carcinoma (HCC)

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
                                              2. Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
                                              3. Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
                                              4. Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
                                              5. Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
                                              6. Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
                                              7. Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
                                              8. Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
                                              9. Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
                                              10. McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
                                              11. Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
                                              12. Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Fibrolamellar carcinoma (FLC) of liver
                                                      • Synonyms

                                                        • Fibrolamellar hepatocellular carcinoma
                                                      • Definitions

                                                        • Uncommon malignant hepatocellular tumor
                                                          • Distinct clinical, histopathologic, and imaging features differentiate it from conventional hepatocellular carcinoma (HCC)

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Ganeshan D et al: Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 202(3):544-52, 2014
                                                                                          2. Roth CG et al: Hepatocellular carcinoma and other hepatic malignancies: MR imaging. Radiol Clin North Am. 52(4):683-707, 2014
                                                                                          3. Mayo SC et al: Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J Am Coll Surg. 218(2):196-205, 2014
                                                                                          4. Taylor SL et al: Hepatobiliary pathology. Curr Opin Gastroenterol. 27(3):248-55, 2011
                                                                                          5. Ward SC et al: Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. 31(1):61-70, 2011
                                                                                          6. Fouzas I et al: "Preemptive" live donor liver transplantation for fibrolamellar hepatocellular carcinoma: a case report. Transplant Proc. 40(10):3806-7, 2008
                                                                                          7. Smith MT et al: Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 28(2):609-13, 2008
                                                                                          8. Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. 217(1):145-51, 2000
                                                                                          9. Ichikawa T et al: Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 213(2):352-61, 1999
                                                                                          10. McLarney JK et al: Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 19(2):453-71, 1999
                                                                                          11. Schlitt HJ et al: Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol. 17(1):324-31, 1999
                                                                                          12. Stevens WR et al: Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. 164(5):1153-8, 1995