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Fibromatosis of Head and Neck
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Aggressive fibromatosis, extraabdominal desmoid, infantile fibromatosis
            • Definitions

              • Rare infiltrative mass lesion of benign monoclonal fibroblast proliferation
                • In H&N, these are deep fibromatoses
                • Superficial fibromatoses most often in extremities

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Lacayo EA et al: Deep neck fibromatosis after diskectomy and cervical fusion: case series and review of the literature. AJR Am J Roentgenol. 1-5, 2016
                                              2. Otero S et al: Desmoid-type fibromatosis. Clin Radiol. 70(9):1038-45, 2015
                                              3. Collin M et al: Ossifying fibroma of the middle turbinate revealed by infection in a young child. Eur Ann Otorhinolaryngol Head Neck Dis. 131(3):193-5, 2014
                                              4. Wang W et al: Age-based treatment of aggressive fibromatosis in the head and neck region. J Oral Maxillofac Surg. 72(2):311-21, 2014
                                              5. Rhim JH et al: Desmoid-type fibromatosis in the head and neck: CT and MR imaging characteristics. Neuroradiology. 55(3):351-9, 2013
                                              6. Soto-Miranda MA et al: Surgical treatment of pediatric desmoid tumors. A 12-year, single-center experience. Ann Surg Oncol. 20(11):3384-90, 2013
                                              7. Meazza C et al: Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer. 116(1):233-40, 2010
                                              8. Guglielmi G et al: Imaging of superficial and deep fibromatosis. Radiol Med. 114(8):1292-307, 2009
                                              9. Lazar AJ et al: Desmoid tumor: from surgical extirpation to molecular dissection. Curr Opin Oncol. 21(4):352-9, 2009
                                              10. McKenzie G et al: Pictorial review: Non-neoplastic soft-tissue masses. Br J Radiol. 82(981):775-85, 2009
                                              11. Schneider M et al: Desmoplastic fibroma of the mandible--review of the literature and presentation of a rare case. Head Face Med. 5:25, 2009
                                              12. Sinno H et al: Desmoid tumors of the pediatric mandible: case report and review. Ann Plast Surg. 62(2):213-9, 2009
                                              13. Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
                                              14. Douglas-Akinwande AC et al: AJR teaching file: facial mass in a child. AJR Am J Roentgenol. 191(3 Suppl):S37-9, 2008
                                              15. Hsu YB et al: Pathology quiz case. Fibromatosis (desmoid tumor) of the neck. Arch Otolaryngol Head Neck Surg. 134(5):559, 560-1, 2008
                                              16. Melis M et al: Multimodality management of desmoid tumors: how important is a negative surgical margin? J Surg Oncol. 98(8):594-602, 2008
                                              17. Sharma A et al: Pediatric aggressive fibromatosis of the head and neck: a 20-year retrospective review. J Pediatr Surg. 43(9):1596-604, 2008
                                              18. Wong SL: Diagnosis and management of desmoid tumors and fibrosarcoma. J Surg Oncol. 97(6):554-8, 2008
                                              19. Basu S et al: Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol. 80(957):750-6, 2007
                                              20. Dinauer PA et al: Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. Radiographics. 27(1):173-87, 2007
                                              21. Goodwin RW et al: MRI appearances of common benign soft-tissue tumours. Clin Radiol. 62(9):843-53, 2007
                                              22. Tolan S et al: Fibromatosis: benign by name but not necessarily by nature. Clin Oncol (R Coll Radiol). 19(5):319-26, 2007
                                              23. Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol. 7(6):438-43, 2006
                                              24. Abikhzer G et al: Aggressive fibromatosis of the head and neck: case report and review of the literature. J Otolaryngol. 34(4):289-94, 2005
                                              25. Collins BJ et al: Desmoid tumors of the head and neck: a review. Ann Plast Surg. 54(1):103-8, 2005
                                              26. Koeda S et al: Extra-abdominal fibromatosis of the cheek: report of a case. J Oral Maxillofac Surg. 63(8):1222-6, 2005
                                              27. Mendenhall WM et al: Aggressive fibromatosis. Am J Clin Oncol. 28(2):211-5, 2005
                                              28. Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin North Am. 19(3):565-71, vii-viii, 2005
                                              29. Gronchi A et al: Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol. 21(7):1390-7, 2003
                                              30. Janinis J et al: The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol. 14(2):181-90, 2003
                                              31. Zlotecki RA et al: External beam radiotherapy for primary and adjuvant management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys. 54(1):177-181, 2002
                                              32. Abdelkader M et al: Aggressive fibromatosis of the head and neck (desmoid tumours). J Laryngol Otol. 115(10):772-6, 2001
                                              33. Robbin MR et al: Imaging of musculoskeletal fibromatosis. RadioGraphics. 21(10):585-600, 2001
                                              34. Hoos A et al: Desmoid tumors of the head and neck--a clinical study of a rare entity. Head Neck. 22(8):814-21, 2000
                                              35. Pignatti G et al: Extraabdominal desmoid tumor. A study of 83 cases. Clin Orthop. (375):207-13, 2000
                                              36. Flacke S et al: Infantile fibromatosis of the neck with intracranial involvement: MR and CT findings. AJNR Am J Neuroradiol. 20(5):923-5, 1999
                                              37. Garant M et al: Aggressive fibromatosis of the neck: MR findings. AJNR Am J Neuroradiol. 18(8):1429-31, 1997
                                              38. Vandevenne JE et al: New concepts in understanding evolution of desmoid tumors: MR imaging of 30 lesions. Eur Radiol. 7(7):1013-9, 1997
                                              39. Faulkner LB et al: Pediatric desmoid tumor: retrospective analysis of 63 cases. J Clin Oncol. 13(11):2813-8, 1995
                                              40. Lewin JS et al: Aggressive fibromatosis of the prevertebral and retropharyngeal spaces: MR and CT characteristics. AJNR Am J Neuroradiol. 16(4 Suppl):897-900, 1995
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Aggressive fibromatosis, extraabdominal desmoid, infantile fibromatosis
                                                        • Definitions

                                                          • Rare infiltrative mass lesion of benign monoclonal fibroblast proliferation
                                                            • In H&N, these are deep fibromatoses
                                                            • Superficial fibromatoses most often in extremities

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Imaging Recommendations

                                                                • Nuclear Medicine Findings

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Lacayo EA et al: Deep neck fibromatosis after diskectomy and cervical fusion: case series and review of the literature. AJR Am J Roentgenol. 1-5, 2016
                                                                                          2. Otero S et al: Desmoid-type fibromatosis. Clin Radiol. 70(9):1038-45, 2015
                                                                                          3. Collin M et al: Ossifying fibroma of the middle turbinate revealed by infection in a young child. Eur Ann Otorhinolaryngol Head Neck Dis. 131(3):193-5, 2014
                                                                                          4. Wang W et al: Age-based treatment of aggressive fibromatosis in the head and neck region. J Oral Maxillofac Surg. 72(2):311-21, 2014
                                                                                          5. Rhim JH et al: Desmoid-type fibromatosis in the head and neck: CT and MR imaging characteristics. Neuroradiology. 55(3):351-9, 2013
                                                                                          6. Soto-Miranda MA et al: Surgical treatment of pediatric desmoid tumors. A 12-year, single-center experience. Ann Surg Oncol. 20(11):3384-90, 2013
                                                                                          7. Meazza C et al: Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer. 116(1):233-40, 2010
                                                                                          8. Guglielmi G et al: Imaging of superficial and deep fibromatosis. Radiol Med. 114(8):1292-307, 2009
                                                                                          9. Lazar AJ et al: Desmoid tumor: from surgical extirpation to molecular dissection. Curr Opin Oncol. 21(4):352-9, 2009
                                                                                          10. McKenzie G et al: Pictorial review: Non-neoplastic soft-tissue masses. Br J Radiol. 82(981):775-85, 2009
                                                                                          11. Schneider M et al: Desmoplastic fibroma of the mandible--review of the literature and presentation of a rare case. Head Face Med. 5:25, 2009
                                                                                          12. Sinno H et al: Desmoid tumors of the pediatric mandible: case report and review. Ann Plast Surg. 62(2):213-9, 2009
                                                                                          13. Chung EM et al: From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit. Radiographics. 28(4):1193-214, 2008
                                                                                          14. Douglas-Akinwande AC et al: AJR teaching file: facial mass in a child. AJR Am J Roentgenol. 191(3 Suppl):S37-9, 2008
                                                                                          15. Hsu YB et al: Pathology quiz case. Fibromatosis (desmoid tumor) of the neck. Arch Otolaryngol Head Neck Surg. 134(5):559, 560-1, 2008
                                                                                          16. Melis M et al: Multimodality management of desmoid tumors: how important is a negative surgical margin? J Surg Oncol. 98(8):594-602, 2008
                                                                                          17. Sharma A et al: Pediatric aggressive fibromatosis of the head and neck: a 20-year retrospective review. J Pediatr Surg. 43(9):1596-604, 2008
                                                                                          18. Wong SL: Diagnosis and management of desmoid tumors and fibrosarcoma. J Surg Oncol. 97(6):554-8, 2008
                                                                                          19. Basu S et al: Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol. 80(957):750-6, 2007
                                                                                          20. Dinauer PA et al: Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. Radiographics. 27(1):173-87, 2007
                                                                                          21. Goodwin RW et al: MRI appearances of common benign soft-tissue tumours. Clin Radiol. 62(9):843-53, 2007
                                                                                          22. Tolan S et al: Fibromatosis: benign by name but not necessarily by nature. Clin Oncol (R Coll Radiol). 19(5):319-26, 2007
                                                                                          23. Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol. 7(6):438-43, 2006
                                                                                          24. Abikhzer G et al: Aggressive fibromatosis of the head and neck: case report and review of the literature. J Otolaryngol. 34(4):289-94, 2005
                                                                                          25. Collins BJ et al: Desmoid tumors of the head and neck: a review. Ann Plast Surg. 54(1):103-8, 2005
                                                                                          26. Koeda S et al: Extra-abdominal fibromatosis of the cheek: report of a case. J Oral Maxillofac Surg. 63(8):1222-6, 2005
                                                                                          27. Mendenhall WM et al: Aggressive fibromatosis. Am J Clin Oncol. 28(2):211-5, 2005
                                                                                          28. Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin North Am. 19(3):565-71, vii-viii, 2005
                                                                                          29. Gronchi A et al: Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol. 21(7):1390-7, 2003
                                                                                          30. Janinis J et al: The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol. 14(2):181-90, 2003
                                                                                          31. Zlotecki RA et al: External beam radiotherapy for primary and adjuvant management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys. 54(1):177-181, 2002
                                                                                          32. Abdelkader M et al: Aggressive fibromatosis of the head and neck (desmoid tumours). J Laryngol Otol. 115(10):772-6, 2001
                                                                                          33. Robbin MR et al: Imaging of musculoskeletal fibromatosis. RadioGraphics. 21(10):585-600, 2001
                                                                                          34. Hoos A et al: Desmoid tumors of the head and neck--a clinical study of a rare entity. Head Neck. 22(8):814-21, 2000
                                                                                          35. Pignatti G et al: Extraabdominal desmoid tumor. A study of 83 cases. Clin Orthop. (375):207-13, 2000
                                                                                          36. Flacke S et al: Infantile fibromatosis of the neck with intracranial involvement: MR and CT findings. AJNR Am J Neuroradiol. 20(5):923-5, 1999
                                                                                          37. Garant M et al: Aggressive fibromatosis of the neck: MR findings. AJNR Am J Neuroradiol. 18(8):1429-31, 1997
                                                                                          38. Vandevenne JE et al: New concepts in understanding evolution of desmoid tumors: MR imaging of 30 lesions. Eur Radiol. 7(7):1013-9, 1997
                                                                                          39. Faulkner LB et al: Pediatric desmoid tumor: retrospective analysis of 63 cases. J Clin Oncol. 13(11):2813-8, 1995
                                                                                          40. Lewin JS et al: Aggressive fibromatosis of the prevertebral and retropharyngeal spaces: MR and CT characteristics. AJNR Am J Neuroradiol. 16(4 Suppl):897-900, 1995