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Fibromatosis
Nicole S. Winkler, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Desmoid-type fibromatosis, mammary fibromatosis, aggressive fibromatosis, extraabdominal desmoid tumor, deep-type fibromatosis
            • Definitions

              • Locally infiltrative proliferation of fibroblasts and myofibroblasts without metastatic potential
                • Usually arises from pectoralis fascia with extension into breast
                • Intramammary origin is less common
              • Same tumor in breast as that arising in other locations in body (limbs, head and neck, abdominal wall)

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • CT Findings

                      • Nuclear Medicine Findings

                        • Image-Guided Biopsy

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              Selected References

                                              1. Magro G: Differential diagnosis of benign spindle cell lesions. Surg Pathol Clin. 11(1):91-121, 2018
                                              2. Morales RD et al: Aggressive breast fibromatosis following augmentation mastoplasty: a series of case reports. Ecancermedicalscience. 12:833, 2018
                                              3. Tzur R et al: Desmoid tumor and silicone breast implant surgery: is there really a connection? A literature review. Aesthetic Plast Surg. 42(1):59-63, 2018
                                              4. Kuba MG et al: Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy. Am J Clin Pathol. 148(3):243-250, 2017
                                              5. Penel N et al: Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: a nationwide prospective cohort from the French Sarcoma Group. Eur J Cancer. 83:125-131, 2017
                                              6. Jasperson KW et al: APC-Associated Polyposis Conditions Gene Reviews 1993, last updated 2017
                                              7. Fiore M et al: Desmoid-Type Fibromatosis: Evolving Treatment Standards. Surg Oncol Clin N Am. 25(4):803-26, 2016
                                              8. Roussin S et al: Toward a new strategy in desmoid of the breast? Eur J Surg Oncol. 41(4):571-6, 2015
                                              9. Ebrahim L et al: Fibromatosis of the breast: a pictorial review of the imaging and histopathology findings. Clin Radiol. 69(10):1077-83, 2014
                                              10. Hammoudeh ZS et al: Desmoid tumor (fibromatosis) of the breast after augmentation with saline implants. Plast Reconstr Surg. 129(4):753e-4e, 2012
                                              11. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast. Lyon: IARC, 2012
                                              12. Torres Sousa MY et al: Fibromatosis of the breast in a 52-year-old man (2010: 10b). Eur Radiol. 21(1):221-4, 2011
                                              13. Henderson PW et al: Chest wall spindle cell fibromatosis after breast augmentation. Plast Reconstr Surg. 126(2):94e-5e, 2010
                                              14. Souza FF et al: Case report. PET/CT appearance of desmoid tumour of the chest wall. Br J Radiol. 83(986):e39-42, 2010
                                              15. Glazebrook KN et al: Mammary fibromatosis. AJR Am J Roentgenol. 193(3):856-60, 2009
                                              16. Mazzocchi M et al: Breast desmoid tumor after augmentation mammoplasty: two case reports. Acta Chir Plast. 51(3-4):73-8, 2009
                                              17. Linda A et al: Desmoid tumor of the breast: radiologic appearance with a focus on its magnetic resonance features. Breast J. 14(1):106-7, 2008
                                              18. Neuman HB et al: Desmoid tumors (fibromatoses) of the breast: a 25-year experience. Ann Surg Oncol. 15(1):274-80, 2008
                                              19. Povoski SP et al: Fibromatosis (desmoid tumor) of the breast mimicking a case of ipsilateral metachronous breast cancer. World J Surg Oncol. 4:57, 2006
                                              20. Schwarz GS et al: Fibromatosis of the breast: case report and current concepts in the management of an uncommon lesion. Breast J. 12(1):66-71, 2006
                                              21. Erguvan-Dogan B et al: Primary desmoid tumor (extraabdominal fibromatosis) of the breast. AJR Am J Roentgenol. 185(2):488-9, 2005
                                              22. Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
                                              23. Mesurolle B et al: Dynamic breast MRI in recurrent fibromatosis. AJR Am J Roentgenol. 184(2):696-7; author reply 697, 2005
                                              24. Privette A et al: Desmoid tumor: a case of mistaken identity. Breast J. 11(1):60-4, 2005
                                              25. Nakazono T et al: Dynamic MRI of fibromatosis of the breast. AJR Am J Roentgenol. 181(6):1718-9, 2003
                                              26. Greenberg D et al: Aggressive fibromatosis of the breast: a case report and literature review. Breast J. 8(1):55-7, 2002
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Desmoid-type fibromatosis, mammary fibromatosis, aggressive fibromatosis, extraabdominal desmoid tumor, deep-type fibromatosis
                                                        • Definitions

                                                          • Locally infiltrative proliferation of fibroblasts and myofibroblasts without metastatic potential
                                                            • Usually arises from pectoralis fascia with extension into breast
                                                            • Intramammary origin is less common
                                                          • Same tumor in breast as that arising in other locations in body (limbs, head and neck, abdominal wall)

                                                        IMAGING

                                                        • General Features

                                                          • Mammographic Findings

                                                            • Ultrasonographic Findings

                                                              • MR Findings

                                                                • CT Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Image-Guided Biopsy

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          Selected References

                                                                                          1. Magro G: Differential diagnosis of benign spindle cell lesions. Surg Pathol Clin. 11(1):91-121, 2018
                                                                                          2. Morales RD et al: Aggressive breast fibromatosis following augmentation mastoplasty: a series of case reports. Ecancermedicalscience. 12:833, 2018
                                                                                          3. Tzur R et al: Desmoid tumor and silicone breast implant surgery: is there really a connection? A literature review. Aesthetic Plast Surg. 42(1):59-63, 2018
                                                                                          4. Kuba MG et al: Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy. Am J Clin Pathol. 148(3):243-250, 2017
                                                                                          5. Penel N et al: Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: a nationwide prospective cohort from the French Sarcoma Group. Eur J Cancer. 83:125-131, 2017
                                                                                          6. Jasperson KW et al: APC-Associated Polyposis Conditions Gene Reviews 1993, last updated 2017
                                                                                          7. Fiore M et al: Desmoid-Type Fibromatosis: Evolving Treatment Standards. Surg Oncol Clin N Am. 25(4):803-26, 2016
                                                                                          8. Roussin S et al: Toward a new strategy in desmoid of the breast? Eur J Surg Oncol. 41(4):571-6, 2015
                                                                                          9. Ebrahim L et al: Fibromatosis of the breast: a pictorial review of the imaging and histopathology findings. Clin Radiol. 69(10):1077-83, 2014
                                                                                          10. Hammoudeh ZS et al: Desmoid tumor (fibromatosis) of the breast after augmentation with saline implants. Plast Reconstr Surg. 129(4):753e-4e, 2012
                                                                                          11. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast. Lyon: IARC, 2012
                                                                                          12. Torres Sousa MY et al: Fibromatosis of the breast in a 52-year-old man (2010: 10b). Eur Radiol. 21(1):221-4, 2011
                                                                                          13. Henderson PW et al: Chest wall spindle cell fibromatosis after breast augmentation. Plast Reconstr Surg. 126(2):94e-5e, 2010
                                                                                          14. Souza FF et al: Case report. PET/CT appearance of desmoid tumour of the chest wall. Br J Radiol. 83(986):e39-42, 2010
                                                                                          15. Glazebrook KN et al: Mammary fibromatosis. AJR Am J Roentgenol. 193(3):856-60, 2009
                                                                                          16. Mazzocchi M et al: Breast desmoid tumor after augmentation mammoplasty: two case reports. Acta Chir Plast. 51(3-4):73-8, 2009
                                                                                          17. Linda A et al: Desmoid tumor of the breast: radiologic appearance with a focus on its magnetic resonance features. Breast J. 14(1):106-7, 2008
                                                                                          18. Neuman HB et al: Desmoid tumors (fibromatoses) of the breast: a 25-year experience. Ann Surg Oncol. 15(1):274-80, 2008
                                                                                          19. Povoski SP et al: Fibromatosis (desmoid tumor) of the breast mimicking a case of ipsilateral metachronous breast cancer. World J Surg Oncol. 4:57, 2006
                                                                                          20. Schwarz GS et al: Fibromatosis of the breast: case report and current concepts in the management of an uncommon lesion. Breast J. 12(1):66-71, 2006
                                                                                          21. Erguvan-Dogan B et al: Primary desmoid tumor (extraabdominal fibromatosis) of the breast. AJR Am J Roentgenol. 185(2):488-9, 2005
                                                                                          22. Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
                                                                                          23. Mesurolle B et al: Dynamic breast MRI in recurrent fibromatosis. AJR Am J Roentgenol. 184(2):696-7; author reply 697, 2005
                                                                                          24. Privette A et al: Desmoid tumor: a case of mistaken identity. Breast J. 11(1):60-4, 2005
                                                                                          25. Nakazono T et al: Dynamic MRI of fibromatosis of the breast. AJR Am J Roentgenol. 181(6):1718-9, 2003
                                                                                          26. Greenberg D et al: Aggressive fibromatosis of the breast: a case report and literature review. Breast J. 8(1):55-7, 2002