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Fibrosarcoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Malignant spindle cell tumor of bone in which tumor cells are oriented in fascicular or herringbone pattern

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
                                    2. Li J et al: Fibrosarcoma development 15 years after curettage and bone grafting of giant cell tumor of bone. Orthopedics. 37(5):e512-6, 2014
                                    3. Adachi M et al: Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle. J Craniofac Surg. 23(6):e619-21, 2012
                                    4. Romeo S et al: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 461(5):561-70, 2012
                                    5. Kahn LB et al: Fibrosarcoma of bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 289-90, 2002
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Definitions

                                              • Malignant spindle cell tumor of bone in which tumor cells are oriented in fascicular or herringbone pattern

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
                                                                      2. Li J et al: Fibrosarcoma development 15 years after curettage and bone grafting of giant cell tumor of bone. Orthopedics. 37(5):e512-6, 2014
                                                                      3. Adachi M et al: Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle. J Craniofac Surg. 23(6):e619-21, 2012
                                                                      4. Romeo S et al: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 461(5):561-70, 2012
                                                                      5. Kahn LB et al: Fibrosarcoma of bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 289-90, 2002