Benign entity with wide spectrum of imaging findings
Excess of fibrous tissue compared to other portions of breast; may be global in extent
Historically described as palpable mass reflecting densely collagenized stroma
Now mostly incidental abnormal finding on screening mammography, US or MR
Causes ↑ mammographic density, focal or diffuse
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-9, 2018
Yilmaz R et al: Stromal fibrosis: imaging features with diagnostic contribution of diffusion-weighted MRI. Br J Radiol. 91(1085):20170706, 2018
Dratwa C et al: Breast MR biopsy: pathological and radiological correlation. Eur Radiol. 26(8):2510-9, 2016
Kim J et al: Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
Moschetta M et al: Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
Malik N et al: Underestimation of malignancy in biopsy-proven cases of stromal fibrosis. Br J Radiol. 87(1039):20140182, 2014
Shin S et al: Stromal fibrosis of the breast: outcome analysis. Acta Radiol. 55(4):409-15, 2014
Chan CL et al: Diabetic mastopathy. Breast J. 19(5):533-8, 2013
Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
Lee SJ et al: MRI features of stromal fibrosis of the breast with histopathologic correlation. AJR Am J Roentgenol. 197(3):755-62, 2011
Taskin F et al: Fibrotic lesions of the breast: radiological findings and core-neddle biopsy results. Eur J Radiol. 80(3):e231-6, 2011
Chen JH et al: Fibrocystic change of the breast presenting as a focal lesion mimicking breast cancer in MR imaging. J Magn Reson Imaging. 28(6):1499-505, 2008
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
You JK et al: Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance. J Ultrasound Med. 24(10):1377-84, 2005
Shetty MK et al: Sonographic findings in focal fibrocystic changes of the breast. Ultrasound Q. 18(1):35-40, 2002
Sklair-Levy M et al: Stromal fibrosis of the breast. AJR Am J Roentgenol. 177(3):573-7, 2001
Revelon G et al: Focal fibrosis of the breast: imaging characteristics and histopathologic correlation. Radiology. 216(1):255-9, 2000
Harvey SC et al: Fibrous nodules found at large-core needle biopsy of the breast: imaging features. Radiology. 211(2):535-40, 1999
Rosen EL et al: Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy. AJR Am J Roentgenol. 173(6):1657-62, 1999
Venta LA et al: Imaging features of focal breast fibrosis: mammographic-pathologic correlation of noncalcified breast lesions. AJR Am J Roentgenol. 173(2):309-16, 1999
Berg WA et al: Predictive value of specimen radiography for core needle biopsy of noncalcified breast masses. AJR Am J Roentgenol. 171(6):1671-8, 1998
Berg WA et al: Lessons from mammographic-histopathologic correlation of large-core needle breast biopsy. Radiographics. 16(5):1111-30, 1996
Benign entity with wide spectrum of imaging findings
Excess of fibrous tissue compared to other portions of breast; may be global in extent
Historically described as palpable mass reflecting densely collagenized stroma
Now mostly incidental abnormal finding on screening mammography, US or MR
Causes ↑ mammographic density, focal or diffuse
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Suvannarerg V et al: Clinical, mammographic, and ultrasonographic characteristics of diabetic mastopathy: A case series. Clin Imaging. 53:204-9, 2018
Yilmaz R et al: Stromal fibrosis: imaging features with diagnostic contribution of diffusion-weighted MRI. Br J Radiol. 91(1085):20170706, 2018
Dratwa C et al: Breast MR biopsy: pathological and radiological correlation. Eur Radiol. 26(8):2510-9, 2016
Kim J et al: Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis. Ultrasonography. 35(2):140-7, 2016
Moschetta M et al: Diabetic mastopathy: a diagnostic challenge in breast sonography. J Clin Ultrasound. 43(2):113-7, 2015
Malik N et al: Underestimation of malignancy in biopsy-proven cases of stromal fibrosis. Br J Radiol. 87(1039):20140182, 2014
Shin S et al: Stromal fibrosis of the breast: outcome analysis. Acta Radiol. 55(4):409-15, 2014
Chan CL et al: Diabetic mastopathy. Breast J. 19(5):533-8, 2013
Bowman E et al: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J. 18(3):242-7, 2012
Lee SJ et al: MRI features of stromal fibrosis of the breast with histopathologic correlation. AJR Am J Roentgenol. 197(3):755-62, 2011
Taskin F et al: Fibrotic lesions of the breast: radiological findings and core-neddle biopsy results. Eur J Radiol. 80(3):e231-6, 2011
Chen JH et al: Fibrocystic change of the breast presenting as a focal lesion mimicking breast cancer in MR imaging. J Magn Reson Imaging. 28(6):1499-505, 2008
Goel NB et al: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics. 25(6):1547-59, 2005
You JK et al: Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance. J Ultrasound Med. 24(10):1377-84, 2005
Shetty MK et al: Sonographic findings in focal fibrocystic changes of the breast. Ultrasound Q. 18(1):35-40, 2002
Sklair-Levy M et al: Stromal fibrosis of the breast. AJR Am J Roentgenol. 177(3):573-7, 2001
Revelon G et al: Focal fibrosis of the breast: imaging characteristics and histopathologic correlation. Radiology. 216(1):255-9, 2000
Harvey SC et al: Fibrous nodules found at large-core needle biopsy of the breast: imaging features. Radiology. 211(2):535-40, 1999
Rosen EL et al: Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy. AJR Am J Roentgenol. 173(6):1657-62, 1999
Venta LA et al: Imaging features of focal breast fibrosis: mammographic-pathologic correlation of noncalcified breast lesions. AJR Am J Roentgenol. 173(2):309-16, 1999
Berg WA et al: Predictive value of specimen radiography for core needle biopsy of noncalcified breast masses. AJR Am J Roentgenol. 171(6):1671-8, 1998
Berg WA et al: Lessons from mammographic-histopathologic correlation of large-core needle breast biopsy. Radiographics. 16(5):1111-30, 1996
STATdx includes over 200,000 searchable images, including x-ray, CT, MR and ultrasound images. To access all images, please log in or subscribe.