link
Bookmarks
Musculoskeletal
Diagnosis
Non-Trauma
Bone Tumors and Tumor-Like Conditions
Other Bone Tumors
Fibrous Dysplasia
Fibrous Dysplasia
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
0
23
41
3

KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Fibrous dysplasia (FD)

        • Synonyms

          • Fibrocartilaginous dysplasia, generalized fibrocystic disease of bone, osteitis fibrosa, liposclerosing myxofibrous tumor (LSMFT)

        • Definitions

          • Benign, medullary, fibroosseous neoplasm of distorted, poorly organized, and inadequately mineralized bone and intervening fibrous tissue

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Nuclear Medicine Findings

                  • Image-Guided Biopsy

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Haygood TM et al: Benign osseous tumors and tumor-like conditions. Semin Ultrasound CT MR. 42(2):150-63, 2021
                                      2. Li Z et al: Malignant transformation of craniofacial fibrous dysplasia: a systematic review of overall survival. Neurosurg Rev. 43(3):911-21, 2020
                                      3. Siegal GP et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 472-4, 2020
                                      4. Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
                                      5. Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS International Consortium. Orphanet J Rare Dis. 14(1):139, 2019
                                      6. Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
                                      7. Case DB et al: Best cases from the AFIP: atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
                                      8. Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
                                      9. Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
                                      10. Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
                                      11. Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
                                      12. Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
                                      13. Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
                                      14. Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
                                      15. Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
                                      16. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                      17. Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
                                      18. Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
                                      19. Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
                                      20. Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
                                      21. Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
                                      22. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                      23. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                      24. Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
                                      25. Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Fibrous dysplasia (FD)

                                            • Synonyms

                                              • Fibrocartilaginous dysplasia, generalized fibrocystic disease of bone, osteitis fibrosa, liposclerosing myxofibrous tumor (LSMFT)

                                            • Definitions

                                              • Benign, medullary, fibroosseous neoplasm of distorted, poorly organized, and inadequately mineralized bone and intervening fibrous tissue

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Nuclear Medicine Findings

                                                      • Image-Guided Biopsy

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Haygood TM et al: Benign osseous tumors and tumor-like conditions. Semin Ultrasound CT MR. 42(2):150-63, 2021
                                                                          2. Li Z et al: Malignant transformation of craniofacial fibrous dysplasia: a systematic review of overall survival. Neurosurg Rev. 43(3):911-21, 2020
                                                                          3. Siegal GP et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 472-4, 2020
                                                                          4. Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
                                                                          5. Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS International Consortium. Orphanet J Rare Dis. 14(1):139, 2019
                                                                          6. Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
                                                                          7. Case DB et al: Best cases from the AFIP: atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
                                                                          8. Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
                                                                          9. Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
                                                                          10. Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
                                                                          11. Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
                                                                          12. Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
                                                                          13. Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
                                                                          14. Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
                                                                          15. Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
                                                                          16. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                                                          17. Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
                                                                          18. Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
                                                                          19. Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
                                                                          20. Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
                                                                          21. Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
                                                                          22. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                                                          23. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                                                          24. Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
                                                                          25. Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990