Benign, medullary, fibroosseous neoplasm of distorted, poorly organized, and inadequately mineralized bone and intervening fibrous tissue
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Haygood TM et al: Benign osseous tumors and tumor-like conditions. Semin Ultrasound CT MR. 42(2):150-63, 2021
Li Z et al: Malignant transformation of craniofacial fibrous dysplasia: a systematic review of overall survival. Neurosurg Rev. 43(3):911-21, 2020
Siegal GP et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 472-4, 2020
Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS International Consortium. Orphanet J Rare Dis. 14(1):139, 2019
Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
Case DB et al: Best cases from the AFIP: atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990
Benign, medullary, fibroosseous neoplasm of distorted, poorly organized, and inadequately mineralized bone and intervening fibrous tissue
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Haygood TM et al: Benign osseous tumors and tumor-like conditions. Semin Ultrasound CT MR. 42(2):150-63, 2021
Li Z et al: Malignant transformation of craniofacial fibrous dysplasia: a systematic review of overall survival. Neurosurg Rev. 43(3):911-21, 2020
Siegal GP et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 472-4, 2020
Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS International Consortium. Orphanet J Rare Dis. 14(1):139, 2019
Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
Case DB et al: Best cases from the AFIP: atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990
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