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Fibrous Dysplasia
Umesh D. Oza, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Fibrous dysplasia (FD)
              • Synonyms

                • Lichtenstein-Jaffe disease
                • Osteitis fibrosa disseminata
                • Fibrous osteodystrophy
              • Definitions

                • Fibrous tissue replaces normal medullary spaces
                  • Weaker than normal bone
                  • At risk for pain, pathologic fracture, bone deformity
                • Usually an incidental finding

              IMAGING

              • General Features

                • Nuclear Medicine Findings

                  • Radiographic Findings

                    • CT Findings

                      • MR Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                      2. Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
                                      3. Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
                                      4. Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
                                      5. Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
                                      6. Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
                                      7. Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
                                      8. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                                      9. Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
                                      10. Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
                                      11. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                      12. Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
                                      13. Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
                                      14. Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Fibrous dysplasia (FD)
                                                  • Synonyms

                                                    • Lichtenstein-Jaffe disease
                                                    • Osteitis fibrosa disseminata
                                                    • Fibrous osteodystrophy
                                                  • Definitions

                                                    • Fibrous tissue replaces normal medullary spaces
                                                      • Weaker than normal bone
                                                      • At risk for pain, pathologic fracture, bone deformity
                                                    • Usually an incidental finding

                                                  IMAGING

                                                  • General Features

                                                    • Nuclear Medicine Findings

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                                                          2. Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
                                                                          3. Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
                                                                          4. Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
                                                                          5. Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
                                                                          6. Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
                                                                          7. Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
                                                                          8. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                                                                          9. Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
                                                                          10. Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
                                                                          11. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                                                          12. Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
                                                                          13. Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
                                                                          14. Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001