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Fibrous Dysplasia
Fathima Fijula P. Manzil, MD; Umesh D. Oza, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Fibrous dysplasia (FD): Fibrous tissue replaces normal medullary spaces
                  • Weaker than normal bone
                  • At risk for pain, pathologic fracture, bone deformity
                • Usually incidental finding
                • Monostotic (affecting 1 bone) and polyostotic (affecting > 1 bone)

              IMAGING

              • General Features

                • Nuclear Medicine Findings

                  • Radiographic Findings

                    • CT Findings

                      • MR Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Kochanowski NE et al: Radiographic diagnosis of fibrous dysplasia in maxilla. Cureus. 10(8):e3127, 2018
                                        2. Zhang L et al: The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia. BMC Med Imaging. 17(1):46, 2017
                                        3. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                        4. Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
                                        5. Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
                                        6. Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
                                        7. Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
                                        8. Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
                                        9. Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
                                        10. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                                        11. Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
                                        12. Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
                                        13. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                        14. Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
                                        15. Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
                                        16. Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Fibrous dysplasia (FD): Fibrous tissue replaces normal medullary spaces
                                                        • Weaker than normal bone
                                                        • At risk for pain, pathologic fracture, bone deformity
                                                      • Usually incidental finding
                                                      • Monostotic (affecting 1 bone) and polyostotic (affecting > 1 bone)

                                                    IMAGING

                                                    • General Features

                                                      • Nuclear Medicine Findings

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Kochanowski NE et al: Radiographic diagnosis of fibrous dysplasia in maxilla. Cureus. 10(8):e3127, 2018
                                                                              2. Zhang L et al: The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia. BMC Med Imaging. 17(1):46, 2017
                                                                              3. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                                                              4. Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
                                                                              5. Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
                                                                              6. Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
                                                                              7. Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
                                                                              8. Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
                                                                              9. Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
                                                                              10. Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
                                                                              11. Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
                                                                              12. Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
                                                                              13. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                                                              14. Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
                                                                              15. Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
                                                                              16. Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001