Fibrous dysplasia (FD): Fibrous tissue replaces normal medullary spaces
Weaker than normal bone
At risk for pain, pathologic fracture, bone deformity
Usually incidental finding
Monostotic (affecting 1 bone) and polyostotic (affecting > 1 bone)
IMAGING
General Features
Nuclear Medicine Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kochanowski NE et al: Radiographic diagnosis of fibrous dysplasia in maxilla. Cureus. 10(8):e3127, 2018
Zhang L et al: The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia. BMC Med Imaging. 17(1):46, 2017
Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001
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KEY FACTS
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TERMINOLOGY
Definitions
Fibrous dysplasia (FD): Fibrous tissue replaces normal medullary spaces
Weaker than normal bone
At risk for pain, pathologic fracture, bone deformity
Usually incidental finding
Monostotic (affecting 1 bone) and polyostotic (affecting > 1 bone)
IMAGING
General Features
Nuclear Medicine Findings
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Kochanowski NE et al: Radiographic diagnosis of fibrous dysplasia in maxilla. Cureus. 10(8):e3127, 2018
Zhang L et al: The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia. BMC Med Imaging. 17(1):46, 2017
Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
Bloem JL et al: Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 81(12):3793-801, 2012
Hsu W et al: Radionuclide imaging in the diagnosis and management of orthopaedic disease. J Am Acad Orthop Surg. 20(3):151-9, 2012
Sandhu SV et al: Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. J Oral Maxillofac Pathol. 16(2):301-5, 2012
Zhang Y et al: Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012:957364, 2012
Amit M et al: Fibrous dysplasia of the sphenoid and skull base. Otolaryngol Clin North Am. 44(4):891-902, vii-viii, 2011
Ihde LL et al: Sclerosing bone dysplasias: review and differentiation from other causes of osteosclerosis. Radiographics. 31(7):1865-82, 2011
Cook GJ et al: Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 40(1):52-61, 2010
Dumitrescu CE et al: McCune-Albright syndrome. Orphanet J Rare Dis. 3:12, 2008
Leet AI et al: Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. J Child Orthop. 1(1):3-17, 2007
Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
Nakahara T et al: Use of bone SPECT in the evaluation of fibrous dysplasia of the skull. Clin Nucl Med. 29(9):554-9, 2004
Zhibin Y et al: The role of radionuclide bone scintigraphy in fibrous dysplasia of bone. Clin Nucl Med. 29(3):177-80, 2004
Aoki J et al: FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 219(3):774-7, 2001
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