McCune-Albright syndrome (MAS): One of the most common FD syndromes
Jaffe-Lichtenstein dysplasia (monostotic FD)
Definitions
Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
Defect in osteoblastic differentiation and maturation
One of the most common fibroosseous lesions
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Cleven AHG et al: Molecular findings in maxillofacial bone tumours and its diagnostic value. Virchows Arch. 476(1):159-74, 2020
Gutierrez LB et al: Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. Clin Imaging. 62:23-32, 2020
Kinnunen AR et al: Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia-a systematic review. Skeletal Radiol. 49(6):837-45, 2020
Pons Escoda A et al: Imaging of skull vault tumors in adults. Insights Imaging. 11(1):23, 2020
van der Bruggen W et al: Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT. Eur J Nucl Med Mol Imaging. 47(6):1527-37, 2020
Butscheidt S et al: Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects. J Neurosurg. 1-10, 2019
Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
Gohil A et al: FGF23 and associated disorders of phosphate wasting. Pediatr Endocrinol Rev. 17(1):17-34, 2019
Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium. Orphanet J Rare Dis. 14(1):139, 2019
Kabali TM et al: Craniofacial fibrous dysplasia associated with McCune-Albright syndrome: challenges in diagnosis and treatment: case reports. BMC Oral Health. 19(1):180, 2019
Pereira TDSF et al: Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features. J Oral Pathol Med. 48(1):3-9, 2019
Kushchayeva YS et al: Fibrous dysplasia for radiologists: beyond ground glass bone matrix. Insights Imaging. 9(6):1035-56, 2018
Ostertag H et al: [The activating GNAS mutation: a survey of fibrous dysplasia, its associated syndromes, and other skeletal and extraskeletal lesions.] Pathologe. 39(2):146-53, 2018
Rowe SP et al: 3D cinematic rendering of the calvarium, maxillofacial structures, and skull base: preliminary observations. Br J Radiol. 91(1086):20170826, 2018
Wilson M et al: Fibro-osseous lesions of the skull base in the pediatric population. J Neurol Surg B Skull Base. 79(1):31-6, 2018
McCune-Albright syndrome (MAS): One of the most common FD syndromes
Jaffe-Lichtenstein dysplasia (monostotic FD)
Definitions
Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
Defect in osteoblastic differentiation and maturation
One of the most common fibroosseous lesions
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Cleven AHG et al: Molecular findings in maxillofacial bone tumours and its diagnostic value. Virchows Arch. 476(1):159-74, 2020
Gutierrez LB et al: Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. Clin Imaging. 62:23-32, 2020
Kinnunen AR et al: Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia-a systematic review. Skeletal Radiol. 49(6):837-45, 2020
Pons Escoda A et al: Imaging of skull vault tumors in adults. Insights Imaging. 11(1):23, 2020
van der Bruggen W et al: Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT. Eur J Nucl Med Mol Imaging. 47(6):1527-37, 2020
Butscheidt S et al: Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects. J Neurosurg. 1-10, 2019
Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
Gohil A et al: FGF23 and associated disorders of phosphate wasting. Pediatr Endocrinol Rev. 17(1):17-34, 2019
Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium. Orphanet J Rare Dis. 14(1):139, 2019
Kabali TM et al: Craniofacial fibrous dysplasia associated with McCune-Albright syndrome: challenges in diagnosis and treatment: case reports. BMC Oral Health. 19(1):180, 2019
Pereira TDSF et al: Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features. J Oral Pathol Med. 48(1):3-9, 2019
Kushchayeva YS et al: Fibrous dysplasia for radiologists: beyond ground glass bone matrix. Insights Imaging. 9(6):1035-56, 2018
Ostertag H et al: [The activating GNAS mutation: a survey of fibrous dysplasia, its associated syndromes, and other skeletal and extraskeletal lesions.] Pathologe. 39(2):146-53, 2018
Rowe SP et al: 3D cinematic rendering of the calvarium, maxillofacial structures, and skull base: preliminary observations. Br J Radiol. 91(1086):20170826, 2018
Wilson M et al: Fibro-osseous lesions of the skull base in the pediatric population. J Neurol Surg B Skull Base. 79(1):31-6, 2018
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