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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Fibrous dysplasia (FD)
Synonyms
- Craniofacial fibrous dysplasia (CFD), osteitis fibrosa, osteodystrophy fibrosa
- McCune-Albright syndrome (MAS): One of the most common FD syndromes
- Jaffe-Lichtenstein dysplasia (monostotic FD)
Definitions
- Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
- Defect in osteoblastic differentiation and maturation
- One of the most common fibroosseous lesions
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Cleven AHG et al: Molecular findings in maxillofacial bone tumours and its diagnostic value. Virchows Arch. 476(1):159-74, 2020
- Gutierrez LB et al: Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. Clin Imaging. 62:23-32, 2020
- Kinnunen AR et al: Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia-a systematic review. Skeletal Radiol. 49(6):837-45, 2020
- Pons Escoda A et al: Imaging of skull vault tumors in adults. Insights Imaging. 11(1):23, 2020
- van der Bruggen W et al: Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT. Eur J Nucl Med Mol Imaging. 47(6):1527-37, 2020
- Butscheidt S et al: Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects. J Neurosurg. 1-10, 2019
- Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
- Gohil A et al: FGF23 and associated disorders of phosphate wasting. Pediatr Endocrinol Rev. 17(1):17-34, 2019
- Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium. Orphanet J Rare Dis. 14(1):139, 2019
- Kabali TM et al: Craniofacial fibrous dysplasia associated with McCune-Albright syndrome: challenges in diagnosis and treatment: case reports. BMC Oral Health. 19(1):180, 2019
- Pereira TDSF et al: Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features. J Oral Pathol Med. 48(1):3-9, 2019
- Kushchayeva YS et al: Fibrous dysplasia for radiologists: beyond ground glass bone matrix. Insights Imaging. 9(6):1035-56, 2018
- Ostertag H et al: [The activating GNAS mutation: a survey of fibrous dysplasia, its associated syndromes, and other skeletal and extraskeletal lesions.] Pathologe. 39(2):146-53, 2018
- Rowe SP et al: 3D cinematic rendering of the calvarium, maxillofacial structures, and skull base: preliminary observations. Br J Radiol. 91(1086):20170826, 2018
- Wilson M et al: Fibro-osseous lesions of the skull base in the pediatric population. J Neurol Surg B Skull Base. 79(1):31-6, 2018
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Fibrous dysplasia (FD)
Synonyms
- Craniofacial fibrous dysplasia (CFD), osteitis fibrosa, osteodystrophy fibrosa
- McCune-Albright syndrome (MAS): One of the most common FD syndromes
- Jaffe-Lichtenstein dysplasia (monostotic FD)
Definitions
- Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
- Defect in osteoblastic differentiation and maturation
- One of the most common fibroosseous lesions
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Cleven AHG et al: Molecular findings in maxillofacial bone tumours and its diagnostic value. Virchows Arch. 476(1):159-74, 2020
- Gutierrez LB et al: Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. Clin Imaging. 62:23-32, 2020
- Kinnunen AR et al: Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia-a systematic review. Skeletal Radiol. 49(6):837-45, 2020
- Pons Escoda A et al: Imaging of skull vault tumors in adults. Insights Imaging. 11(1):23, 2020
- van der Bruggen W et al: Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT. Eur J Nucl Med Mol Imaging. 47(6):1527-37, 2020
- Butscheidt S et al: Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects. J Neurosurg. 1-10, 2019
- Franz D et al: Milk cloud appearance-a characteristic sign of fibrous dysplasia on contrast-enhanced MR imaging. Eur Radiol. 29(7):3424-30, 2019
- Gohil A et al: FGF23 and associated disorders of phosphate wasting. Pediatr Endocrinol Rev. 17(1):17-34, 2019
- Javaid MK et al: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium. Orphanet J Rare Dis. 14(1):139, 2019
- Kabali TM et al: Craniofacial fibrous dysplasia associated with McCune-Albright syndrome: challenges in diagnosis and treatment: case reports. BMC Oral Health. 19(1):180, 2019
- Pereira TDSF et al: Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features. J Oral Pathol Med. 48(1):3-9, 2019
- Kushchayeva YS et al: Fibrous dysplasia for radiologists: beyond ground glass bone matrix. Insights Imaging. 9(6):1035-56, 2018
- Ostertag H et al: [The activating GNAS mutation: a survey of fibrous dysplasia, its associated syndromes, and other skeletal and extraskeletal lesions.] Pathologe. 39(2):146-53, 2018
- Rowe SP et al: 3D cinematic rendering of the calvarium, maxillofacial structures, and skull base: preliminary observations. Br J Radiol. 91(1086):20170826, 2018
- Wilson M et al: Fibro-osseous lesions of the skull base in the pediatric population. J Neurol Surg B Skull Base. 79(1):31-6, 2018
