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Fibrous Dysplasia
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Fibrous dysplasia (FD)
        • Synonyms

          • Fibrocartilaginous dysplasia, generalized fibrocystic disease of bone, osteitis fibrosa
        • Definitions

          • Benign fibroosseous lesion

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Nuclear Medicine Findings

                  • Image-Guided Biopsy

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
                                      2. Case DB et al: Best cases from the AFIP: Atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
                                      3. Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
                                      4. Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
                                      5. Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
                                      6. Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
                                      7. Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
                                      8. Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
                                      9. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                      10. Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
                                      11. Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
                                      12. Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
                                      13. Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
                                      14. Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
                                      15. Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
                                      16. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                      17. Siegal G et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 341-2, 2002
                                      18. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                      19. Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
                                      20. Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Fibrous dysplasia (FD)
                                            • Synonyms

                                              • Fibrocartilaginous dysplasia, generalized fibrocystic disease of bone, osteitis fibrosa
                                            • Definitions

                                              • Benign fibroosseous lesion

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Nuclear Medicine Findings

                                                      • Image-Guided Biopsy

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Su MG et al: Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. Skeletal Radiol. 40(3):295-302, 2011
                                                                          2. Case DB et al: Best cases from the AFIP: Atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 30(3):827-32, 2010
                                                                          3. Doganavsargil B et al: Secondary osteosarcoma arising in fibrous dysplasia, case report. Arch Orthop Trauma Surg. 129(4):439-44, 2009
                                                                          4. Beele X et al: Mazabraud syndrome. JBR-BTR. 91(3):84-5, 2008
                                                                          5. Bonekamp D et al: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med. 33(12):909-11, 2008
                                                                          6. Bulakbaşi N et al: CT and MRI in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia in McCune-Albright syndrome. Diagn Interv Radiol. 14(4):177-81, 2008
                                                                          7. Huening MA et al: Fine-needle aspiration of fibrous dysplasia of bone: a worthwhile endeavor or not? Diagn Cytopathol. 36(5):325-30, 2008
                                                                          8. Kuznetsov SA et al: Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone. J Bone Miner Res. 23(11):1731-40, 2008
                                                                          9. Lisle DA et al: Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol. 52(4):325-32, 2008
                                                                          10. Lädermann A et al: Unusual radiologic presentation of monostotic fibrous dysplasia. Orthopedics. 31(3):282, 2008
                                                                          11. Mäkitie AA et al: Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature. Clin Rheumatol. 27(6):809-12, 2008
                                                                          12. Bahk WJ et al: Cystic fibrous dysplasia in the long bone. Orthopedics. 30(10):871-3, 2007
                                                                          13. Daneman A et al: McCune-Albright syndrome. J Pediatr Endocrinol Metab. 20(12):1265, 2007
                                                                          14. Kao CH et al: Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 32(5):409-10, 2007
                                                                          15. Beaman FD et al: Imaging characteristics of cherubism. AJR Am J Roentgenol. 182(4):1051-4, 2004
                                                                          16. Fitzpatrick KA et al: Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 182(6):1389-98, 2004
                                                                          17. Siegal G et al: Fibrous dysplasia. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 341-2, 2002
                                                                          18. Jee WH et al: Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 167(6):1523-7, 1996
                                                                          19. Ruggieri P et al: Malignancies in fibrous dysplasia. Cancer. 73(5):1411-24, 1994
                                                                          20. Kransdorf MJ et al: Fibrous dysplasia. Radiographics. 10(3):519-37, 1990