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Fibrous Dysplasia
Anne G. Osborn, MD, FACR; Miral D. Jhaveri, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Fibrous dysplasia (FD)
          • Synonyms

            • Craniofacial fibrous dysplasia (CFD), osteitis fibrosa, osteodystrophy fibrosa
            • McCune-Albright syndrome (MAS): One of the most common FD syndromes
            • Jaffe-Lichtenstein dysplasia (monostotic FD)
          • Definitions

            • Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
            • Defect in osteoblastic differentiation and maturation
            • One of the most common fibroosseous lesions

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Bowers CA et al: Surgical treatment of craniofacial fibrous dysplasia in adults. Neurosurg Rev. 37(1):47-53, 2014
                                            2. Boyce AM et al: A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone. J Clin Endocrinol Metab. 99(11):4133-40, 2014
                                            3. Frisch CD et al: Fibrous dysplasia of the temporal bone: A review of 66 cases. Laryngoscope. ePub, 2014
                                            4. Neelakantan A et al: Benign and malignant diseases of the clivus. Clin Radiol. 69(12):1295-303, 2014
                                            5. Rossi DC et al: Extensive fibrous dysplasia of skull base: case report. Neurol Sci. ePub, 2014
                                            6. Thomsen MD et al: Clinical and radiological observations in a case series of 26 patients with fibrous dysplasia. Calcif Tissue Int. 94(4):384-95, 2014
                                            7. Zhou SH et al: Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker. Int J Clin Exp Pathol. 7(12):8532-41, 2014
                                            8. Fattah A et al: Paediatric craniofacial fibrous dysplasia: the Hospital for Sick Children experience and treatment philosophy. J Plast Reconstr Aesthet Surg. 66(10):1346-55, 2013
                                            9. Hanifi B et al: Craniofacial fibrous dysplasia. Clin Imaging. 37(6):1109-15, 2013
                                            10. Pruksakorn P et al: Craniofacial fibrous dysplasia. Intern Med. 49(3):249-50, 2010
                                            11. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 59(1):11-25, 2004
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Fibrous dysplasia (FD)
                                                    • Synonyms

                                                      • Craniofacial fibrous dysplasia (CFD), osteitis fibrosa, osteodystrophy fibrosa
                                                      • McCune-Albright syndrome (MAS): One of the most common FD syndromes
                                                      • Jaffe-Lichtenstein dysplasia (monostotic FD)
                                                    • Definitions

                                                      • Congenital disorder characterized by expanding lesions with mixture of fibrous tissue and woven bone
                                                      • Defect in osteoblastic differentiation and maturation
                                                      • One of the most common fibroosseous lesions

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Bowers CA et al: Surgical treatment of craniofacial fibrous dysplasia in adults. Neurosurg Rev. 37(1):47-53, 2014
                                                                                      2. Boyce AM et al: A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone. J Clin Endocrinol Metab. 99(11):4133-40, 2014
                                                                                      3. Frisch CD et al: Fibrous dysplasia of the temporal bone: A review of 66 cases. Laryngoscope. ePub, 2014
                                                                                      4. Neelakantan A et al: Benign and malignant diseases of the clivus. Clin Radiol. 69(12):1295-303, 2014
                                                                                      5. Rossi DC et al: Extensive fibrous dysplasia of skull base: case report. Neurol Sci. ePub, 2014
                                                                                      6. Thomsen MD et al: Clinical and radiological observations in a case series of 26 patients with fibrous dysplasia. Calcif Tissue Int. 94(4):384-95, 2014
                                                                                      7. Zhou SH et al: Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker. Int J Clin Exp Pathol. 7(12):8532-41, 2014
                                                                                      8. Fattah A et al: Paediatric craniofacial fibrous dysplasia: the Hospital for Sick Children experience and treatment philosophy. J Plast Reconstr Aesthet Surg. 66(10):1346-55, 2013
                                                                                      9. Hanifi B et al: Craniofacial fibrous dysplasia. Clin Imaging. 37(6):1109-15, 2013
                                                                                      10. Pruksakorn P et al: Craniofacial fibrous dysplasia. Intern Med. 49(3):249-50, 2010
                                                                                      11. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 59(1):11-25, 2004