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Fibrous Dysplasia
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Fibrous dysplasia (FD)
              • Definitions

                • Monostotic: Single lesion
                • Polyostotic: Multiple lesions, often associated with growth disturbances
                • McCune-Albright syndrome: Polyostotic FD, precocious puberty, café au lait skin lesions

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Wu FL et al: Polyostotic fibrous dysplasia involving the thoracic spine with myelopathy: case report and review of the literature. Spine J. 14(1):e11-5, 2014
                                          2. Zhong H et al: Monostotic fibrous dysplasia of cervical spine. Joint Bone Spine. ePub, 2014
                                          3. Gundgurthi A et al: Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery? Indian J Endocrinol Metab. 17(6):1108-13, 2013
                                          4. Wu FL et al: Fibrous dysplasia of the mobile spine: report of 8 cases and review of the literature. Spine (Phila Pa 1976). 38(23):2016-22, 2013
                                          5. Park SK et al: CT and MRI of fibrous dysplasia of the spine. Br J Radiol. 85(1015):996-1001, 2012
                                          6. Chen G et al: Polyostotic fibrous dysplasia of the thoracic spine: case report and review of the literature. Spine (Phila Pa 1976). 36(22):E1485-8, 2011
                                          7. Meredith DS et al: Twenty-year follow-up of monostotic fibrous dysplasia of the second cervical vertebra: a case report and review of the literature. J Bone Joint Surg Am. 93(13):e74, 2011
                                          8. Kotil K et al: Fibrous dysplasia in axis treated with vertebroplasty. J Craniovertebr Junction Spine. 1(2):118-21, 2010
                                          9. Schoenfeld AJ et al: Monostotic fibrous dysplasia of the spine: a report of seven cases. J Bone Joint Surg Am. 92(4):984-8, 2010
                                          10. Mancini F et al: Scoliosis and spine involvement in fibrous dysplasia of bone. Eur Spine J. 18(2):196-202, 2009
                                          11. Zhao Z et al: Radiography, bone scintigraphy, SPECT/CT and MRI of fibrous dysplasia of the third lumbar vertebra. Clin Nucl Med. 34(12):898-901, 2009
                                          12. Medow JE et al: Polyostotic fibrous dysplasia of the cervical spine: case report and review of the literature. Spine J. 7(6):712-5, 2007
                                          13. Arazi M et al: Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up. Case report. J Neurosurg. 100(4 Suppl):378-81, 2004
                                          14. Leet AI et al: Fibrous dysplasia in the spine: prevalence of lesions and association with scoliosis. J Bone Joint Surg Am. 86-A(3):531-7, 2004
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Fibrous dysplasia (FD)
                                                      • Definitions

                                                        • Monostotic: Single lesion
                                                        • Polyostotic: Multiple lesions, often associated with growth disturbances
                                                        • McCune-Albright syndrome: Polyostotic FD, precocious puberty, café au lait skin lesions

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Wu FL et al: Polyostotic fibrous dysplasia involving the thoracic spine with myelopathy: case report and review of the literature. Spine J. 14(1):e11-5, 2014
                                                                                  2. Zhong H et al: Monostotic fibrous dysplasia of cervical spine. Joint Bone Spine. ePub, 2014
                                                                                  3. Gundgurthi A et al: Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery? Indian J Endocrinol Metab. 17(6):1108-13, 2013
                                                                                  4. Wu FL et al: Fibrous dysplasia of the mobile spine: report of 8 cases and review of the literature. Spine (Phila Pa 1976). 38(23):2016-22, 2013
                                                                                  5. Park SK et al: CT and MRI of fibrous dysplasia of the spine. Br J Radiol. 85(1015):996-1001, 2012
                                                                                  6. Chen G et al: Polyostotic fibrous dysplasia of the thoracic spine: case report and review of the literature. Spine (Phila Pa 1976). 36(22):E1485-8, 2011
                                                                                  7. Meredith DS et al: Twenty-year follow-up of monostotic fibrous dysplasia of the second cervical vertebra: a case report and review of the literature. J Bone Joint Surg Am. 93(13):e74, 2011
                                                                                  8. Kotil K et al: Fibrous dysplasia in axis treated with vertebroplasty. J Craniovertebr Junction Spine. 1(2):118-21, 2010
                                                                                  9. Schoenfeld AJ et al: Monostotic fibrous dysplasia of the spine: a report of seven cases. J Bone Joint Surg Am. 92(4):984-8, 2010
                                                                                  10. Mancini F et al: Scoliosis and spine involvement in fibrous dysplasia of bone. Eur Spine J. 18(2):196-202, 2009
                                                                                  11. Zhao Z et al: Radiography, bone scintigraphy, SPECT/CT and MRI of fibrous dysplasia of the third lumbar vertebra. Clin Nucl Med. 34(12):898-901, 2009
                                                                                  12. Medow JE et al: Polyostotic fibrous dysplasia of the cervical spine: case report and review of the literature. Spine J. 7(6):712-5, 2007
                                                                                  13. Arazi M et al: Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up. Case report. J Neurosurg. 100(4 Suppl):378-81, 2004
                                                                                  14. Leet AI et al: Fibrous dysplasia in the spine: prevalence of lesions and association with scoliosis. J Bone Joint Surg Am. 86-A(3):531-7, 2004