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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Subdermal fibromatous tumor of infancy
Definitions
- Benign soft tissue mass of infancy and young children, showing organoid, triphasic morphology with bundles of bland fibroblastic/myofibroblastic cells, primitive, rounded, stellate cells with myxoid stroma, and variable amounts of mature adipose tissue
- Lesion is complex neoplasm rather than hamartoma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Drabent P et al: Update on superficial spindle cell mesenchymal tumors in children. Dermatopathology (Basel). 8(3):285-300, 2021
- Al-Ibraheemi A et al: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 59-60, 2020
- Navarro OM: Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT MR. 41(5):498-512, 2020
- Yu G et al: Fibrous hamartoma of infancy: a clinical pathological analysis of seventeen cases. Int J Clin Exp Pathol. 8(3):3374-7, 2015
- Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 241-3, 2014
- Lee S et al: Ultrasonographic features of fibrous hamartoma of infancy. Skeletal Radiol. 43(5):649-53, 2014
- Saab ST et al: Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 38(3):394-401, 2014
- Stensby JD et al: Benign fibrous hamartoma of infancy: a case of MR imaging paralleling histologic findings. Skeletal Radiol. 43(11):1639-43, 2014
- Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 257-61, 2008
- Hashimoto H: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 58-9, 2002
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Subdermal fibromatous tumor of infancy
Definitions
- Benign soft tissue mass of infancy and young children, showing organoid, triphasic morphology with bundles of bland fibroblastic/myofibroblastic cells, primitive, rounded, stellate cells with myxoid stroma, and variable amounts of mature adipose tissue
- Lesion is complex neoplasm rather than hamartoma
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Drabent P et al: Update on superficial spindle cell mesenchymal tumors in children. Dermatopathology (Basel). 8(3):285-300, 2021
- Al-Ibraheemi A et al: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 59-60, 2020
- Navarro OM: Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT MR. 41(5):498-512, 2020
- Yu G et al: Fibrous hamartoma of infancy: a clinical pathological analysis of seventeen cases. Int J Clin Exp Pathol. 8(3):3374-7, 2015
- Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 241-3, 2014
- Lee S et al: Ultrasonographic features of fibrous hamartoma of infancy. Skeletal Radiol. 43(5):649-53, 2014
- Saab ST et al: Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 38(3):394-401, 2014
- Stensby JD et al: Benign fibrous hamartoma of infancy: a case of MR imaging paralleling histologic findings. Skeletal Radiol. 43(11):1639-43, 2014
- Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 257-61, 2008
- Hashimoto H: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 58-9, 2002
