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Fibrous Hamartoma of Infancy
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Subdermal fibromatous tumor of infancy
            • Definitions

              • Benign soft tissue mass of infancy and young children, showing organoid, triphasic morphology with bundles of bland fibroblastic/myofibroblastic cells, primitive, rounded, stellate cells with myxoid stroma, and variable amounts of mature adipose tissue
              • Lesion is complex neoplasm rather than hamartoma

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Drabent P et al: Update on superficial spindle cell mesenchymal tumors in children. Dermatopathology (Basel). 8(3):285-300, 2021
                                        2. Al-Ibraheemi A et al: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 59-60, 2020
                                        3. Navarro OM: Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT MR. 41(5):498-512, 2020
                                        4. Yu G et al: Fibrous hamartoma of infancy: a clinical pathological analysis of seventeen cases. Int J Clin Exp Pathol. 8(3):3374-7, 2015
                                        5. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 241-3, 2014
                                        6. Lee S et al: Ultrasonographic features of fibrous hamartoma of infancy. Skeletal Radiol. 43(5):649-53, 2014
                                        7. Saab ST et al: Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 38(3):394-401, 2014
                                        8. Stensby JD et al: Benign fibrous hamartoma of infancy: a case of MR imaging paralleling histologic findings. Skeletal Radiol. 43(11):1639-43, 2014
                                        9. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 257-61, 2008
                                        10. Hashimoto H: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 58-9, 2002
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Subdermal fibromatous tumor of infancy
                                                  • Definitions

                                                    • Benign soft tissue mass of infancy and young children, showing organoid, triphasic morphology with bundles of bland fibroblastic/myofibroblastic cells, primitive, rounded, stellate cells with myxoid stroma, and variable amounts of mature adipose tissue
                                                    • Lesion is complex neoplasm rather than hamartoma

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Drabent P et al: Update on superficial spindle cell mesenchymal tumors in children. Dermatopathology (Basel). 8(3):285-300, 2021
                                                                              2. Al-Ibraheemi A et al: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 59-60, 2020
                                                                              3. Navarro OM: Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT MR. 41(5):498-512, 2020
                                                                              4. Yu G et al: Fibrous hamartoma of infancy: a clinical pathological analysis of seventeen cases. Int J Clin Exp Pathol. 8(3):3374-7, 2015
                                                                              5. Kransdorf MJ et al: Fibrous and fibrohistiocytic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 241-3, 2014
                                                                              6. Lee S et al: Ultrasonographic features of fibrous hamartoma of infancy. Skeletal Radiol. 43(5):649-53, 2014
                                                                              7. Saab ST et al: Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 38(3):394-401, 2014
                                                                              8. Stensby JD et al: Benign fibrous hamartoma of infancy: a case of MR imaging paralleling histologic findings. Skeletal Radiol. 43(11):1639-43, 2014
                                                                              9. Weiss SW et al: Fibrous tumors of infancy and childhood. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 257-61, 2008
                                                                              10. Hashimoto H: Fibrous hamartoma of infancy. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 58-9, 2002