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Fibroxanthoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
          • Definitions

            • Benign fibrous lesion composed of spindle cells in collagenous matrix
              • Considered by some to be developmental defect rather than true neoplasm
              • BFCD is histologically identical to NOF, so considered same lesion here

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Reporting Tips

                                    Selected References

                                    1. Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
                                    2. Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
                                    3. Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
                                    4. von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
                                    5. Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
                                    6. Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
                                    7. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                                    8. Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
                                    9. Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
                                    10. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
                                    11. Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Synonyms

                                              • Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
                                            • Definitions

                                              • Benign fibrous lesion composed of spindle cells in collagenous matrix
                                                • Considered by some to be developmental defect rather than true neoplasm
                                                • BFCD is histologically identical to NOF, so considered same lesion here

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • MR Findings

                                                    • Nuclear Medicine Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Reporting Tips

                                                                      Selected References

                                                                      1. Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
                                                                      2. Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
                                                                      3. Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
                                                                      4. von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
                                                                      5. Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
                                                                      6. Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
                                                                      7. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                                                                      8. Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
                                                                      9. Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
                                                                      10. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
                                                                      11. Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998