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KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
Definitions
- Benign fibrous lesion composed of spindle cells in collagenous matrix
- Considered by some to be developmental defect rather than true neoplasm
- BFCD is histologically identical to NOF, so considered same lesion here
- Benign fibrous lesion composed of spindle cells in collagenous matrix
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
- Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
- Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
Definitions
- Benign fibrous lesion composed of spindle cells in collagenous matrix
- Considered by some to be developmental defect rather than true neoplasm
- BFCD is histologically identical to NOF, so considered same lesion here
- Benign fibrous lesion composed of spindle cells in collagenous matrix
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
- Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
- Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
