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Musculoskeletal
Diagnosis
Non-Traumatic Disease
Osseous Tumors and Tumor-Like Conditions
Tumor-Like Conditions
Fibroxanthoma
Fibroxanthoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
Definitions
Benign fibrous lesion composed of spindle cells in collagenous matrix
Considered by some to be developmental defect rather than true neoplasm
BFCD is histologically identical to NOF, so considered same lesion here
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Nonossifying fibroma (NOF), benign fibrous cortical defect (BFCD), nonosteogenic fibroma, metaphyseal defect, histiocytic xanthogranuloma
Definitions
Benign fibrous lesion composed of spindle cells in collagenous matrix
Considered by some to be developmental defect rather than true neoplasm
BFCD is histologically identical to NOF, so considered same lesion here
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Philadelphia: Lippencott-Raven. 205-209, 1998
Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
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