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Flat Epithelial Atypia
Marion E. Scoggins, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Flat epithelial atypia (FEA)
            • Synonyms

              • Columnar cell change (CCC)/hyperplasia (CCH) with atypia
              • Columnar alteration with prominent apical snouts and secretions (CAPSS) with atypia
              • Clinging carcinoma, monomorphous type
              • Ductal intraepithelial neoplasia (DIN), grade 1A, flat monomorphic type
              • Atypical cystic lobules
            • Definitions

              • Columnar cell lesion with cytologic atypia

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Hugar SB et al: Isolated flat epithelial atypia on core biopsy is associated with a low risk of upgrade at excision. Am J Clin Pathol. In press, 2019
                                2. Chan PMY et al: Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision. Breast. 37:13-17, 2018
                                3. Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
                                4. Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
                                5. McCroskey Z et al: Flat epithelial atypia in directional vacuum-assisted biopsy of breast microcalcifications: surgical excision may not be necessary. Mod Pathol. 31(7):1097-1106, 2018
                                6. Ouldamer L et al: All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast. 40:4-9, 2018
                                7. Ouldamer L et al: All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast. 40:4-9, 2018
                                8. Schiaffino S et al: Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy. Br J Radiol. 91(1081):20170484, 2018
                                9. Schiaffino S et al: Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy. Br J Radiol. 91(1081):20170484, 2018
                                10. Usón Junior PLS et al: Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens. Pathol Oncol Res. 24(1):95-99, 2018
                                11. Usón Junior PLS et al: Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens. Pathol Oncol Res. 24(1):95-99, 2018
                                12. El Khoury M et al: Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? Br J Radiol. 90(1072):20160750, 2017
                                13. El Khoury M et al: Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? Br J Radiol. 90(1072):20160750, 2017
                                14. Farshid G et al: Contemporary indications for diagnostic open biopsy in women assessed for screen-detected breast lesions: A ten-year, single institution series of 814 consecutive cases. Breast Cancer Res Treat. 162(1):49-58, 2017
                                15. Farshid G et al: Contemporary indications for diagnostic open biopsy in women assessed for screen-detected breast lesions: A ten-year, single institution series of 814 consecutive cases. Breast Cancer Res Treat. 162(1):49-58, 2017
                                16. Lamb LR et al: Flat Epithelial Atypia: Upgrade Rates and Risk-Stratification Approach to Support Informed Decision Making. J Am Coll Surg. 225(6):696-701, 2017
                                17. Lamb LR et al: Flat Epithelial Atypia: Upgrade Rates and Risk-Stratification Approach to Support Informed Decision Making. J Am Coll Surg. 225(6):696-701, 2017
                                18. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: A systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                19. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: A systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                20. Samples LS et al: Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast. 34:34-43, 2017
                                21. Samples LS et al: Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast. 34:34-43, 2017
                                22. Acott AA et al: Flat epithelial atypia on core needle biopsy, must we surgically excise? Am J Surg. 212(6):1211-1213, 2016
                                23. Acott AA et al: Flat epithelial atypia on core needle biopsy, must we surgically excise? Am J Surg. 212(6):1211-1213, 2016
                                24. Ahn HS et al: Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound Med Biol. 42(7):1457-63, 2016
                                25. Ahn HS et al: Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound Med Biol. 42(7):1457-63, 2016
                                26. Berry JS et al: Analysis of Clinical and Pathologic Factors of Pure, Flat Epithelial Atypia on Core Needle Biopsy to Aid in the Decision of Excision or Observation. J Cancer. 7(1):1-6, 2016
                                27. Berry JS et al: Analysis of Clinical and Pathologic Factors of Pure, Flat Epithelial Atypia on Core Needle Biopsy to Aid in the Decision of Excision or Observation. J Cancer. 7(1):1-6, 2016
                                28. Calhoun BC et al: Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature. Histopathology. 68(1):138-51, 2016
                                29. Calhoun BC et al: Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature. Histopathology. 68(1):138-51, 2016
                                30. Mooney KL et al: Upgrade rates of high-risk breast lesions diagnosed on core needle biopsy: a single-institution experience and literature review. Mod Pathol. 29(12):1471-1484, 2016
                                31. Mooney KL et al: Upgrade rates of high-risk breast lesions diagnosed on core needle biopsy: a single-institution experience and literature review. Mod Pathol. 29(12):1471-1484, 2016
                                32. Rageth CJ et al: First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Res Treat. 159(2):203-13, 2016
                                33. Rageth CJ et al: First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Res Treat. 159(2):203-13, 2016
                                34. Saladin C et al: Lesions with unclear malignant potential (B3) after minimally invasive breast biopsy: evaluation of vacuum biopsies performed in Switzerland and recommended further management. Acta Radiol. 57(7):815-21, 2016
                                35. Saladin C et al: Lesions with unclear malignant potential (B3) after minimally invasive breast biopsy: evaluation of vacuum biopsies performed in Switzerland and recommended further management. Acta Radiol. 57(7):815-21, 2016
                                36. Yamashita Y et al: Does flat epithelial atypia have rounder nuclei than columnar cell change/hyperplasia? A morphometric approach to columnar cell lesions of the breast. Virchows Arch. 468(6):663-73, 2016
                                37. Yamashita Y et al: Does flat epithelial atypia have rounder nuclei than columnar cell change/hyperplasia? A morphometric approach to columnar cell lesions of the breast. Virchows Arch. 468(6):663-73, 2016
                                38. Calhoun BC et al: Management of flat epithelial atypia on breast core biopsy may be individualized based on correlation with imaging studies. Mod Pathol. 28(5):670-6, 2015
                                39. Calhoun BC et al: Management of flat epithelial atypia on breast core biopsy may be individualized based on correlation with imaging studies. Mod Pathol. 28(5):670-6, 2015
                                40. Cheung YC et al: Assessment of Breast Specimens With or Without Calcifications in Diagnosing Malignant and Atypia for Mammographic Breast Microcalcifications Without Mass: A STARD-Compliant Diagnostic Accuracy Article. Medicine (Baltimore). 94(42):e1832, 2015
                                41. Cheung YC et al: Assessment of Breast Specimens With or Without Calcifications in Diagnosing Malignant and Atypia for Mammographic Breast Microcalcifications Without Mass: A STARD-Compliant Diagnostic Accuracy Article. Medicine (Baltimore). 94(42):e1832, 2015
                                42. Elif A et al: Columnar cell lesions of the breast: radiological features and histological correlation. Med Ultrason. 17(2):147-54, 2015
                                43. Elif A et al: Columnar cell lesions of the breast: radiological features and histological correlation. Med Ultrason. 17(2):147-54, 2015
                                44. Maeda I et al: Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography. Breast Cancer. 22(6):634-40, 2015
                                45. Maeda I et al: Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography. Breast Cancer. 22(6):634-40, 2015
                                46. Morrow M et al: Current management of lesions associated with an increased risk of breast cancer. Nat Rev Clin Oncol. 12(4):227-38, 2015
                                47. Morrow M et al: Current management of lesions associated with an increased risk of breast cancer. Nat Rev Clin Oncol. 12(4):227-38, 2015
                                48. Said SM et al: Flat epithelial atypia and risk of breast cancer: A Mayo cohort study. Cancer. ePub, 2015
                                49. Said SM et al: Flat epithelial atypia and risk of breast cancer: A Mayo cohort study. Cancer. ePub, 2015
                                50. Yu CC et al: Predictors of underestimation of malignancy after image-guided core needle biopsy diagnosis of flat epithelial atypia or atypical ductal hyperplasia. Breast J. 21(3):224-32, 2015
                                51. Yu CC et al: Predictors of underestimation of malignancy after image-guided core needle biopsy diagnosis of flat epithelial atypia or atypical ductal hyperplasia. Breast J. 21(3):224-32, 2015
                                52. Dialani V et al: Does isolated flat epithelial atypia on vacuum-assisted breast core biopsy require surgical excision? Breast J. 20(6):606-14, 2014
                                53. Dialani V et al: Does isolated flat epithelial atypia on vacuum-assisted breast core biopsy require surgical excision? Breast J. 20(6):606-14, 2014
                                54. Gomes DS et al: Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. Diagn Pathol. 9:121, 2014
                                55. Gomes DS et al: Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. Diagn Pathol. 9:121, 2014
                                56. Li Z et al: Incidental atypical proliferative lesions in reduction mammoplasty specimens in patients with a history of breast cancer. Hum Pathol. 45(1):104-9, 2014
                                57. Li Z et al: Incidental atypical proliferative lesions in reduction mammoplasty specimens in patients with a history of breast cancer. Hum Pathol. 45(1):104-9, 2014
                                58. Neal L et al: Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy. Mayo Clin Proc. 89(4):536-47, 2014
                                59. Neal L et al: Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy. Mayo Clin Proc. 89(4):536-47, 2014
                                60. Prowler VL et al: Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy. Breast. 23(4):352-6, 2014
                                61. Prowler VL et al: Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy. Breast. 23(4):352-6, 2014
                                62. Becker AK et al: Flat ductal intraepithelial neoplasia 1A diagnosed at stereotactic core needle biopsy: is excisional biopsy indicated? AJR Am J Roentgenol. 200(3):682-8, 2013
                                63. Becker AK et al: Flat ductal intraepithelial neoplasia 1A diagnosed at stereotactic core needle biopsy: is excisional biopsy indicated? AJR Am J Roentgenol. 200(3):682-8, 2013
                                64. Ceugnart L et al: Pure flat epithelial atypia: is there a place for routine surgery? Diagn Interv Imaging. 94(9):861-9, 2013
                                65. Ceugnart L et al: Pure flat epithelial atypia: is there a place for routine surgery? Diagn Interv Imaging. 94(9):861-9, 2013
                                66. Desouki MM et al: Incidental atypical proliferative lesions in reduction mammoplasty specimens: analysis of 2498 cases from 2 tertiary women's health centers. Hum Pathol. 44(9):1877-81, 2013
                                67. Desouki MM et al: Incidental atypical proliferative lesions in reduction mammoplasty specimens: analysis of 2498 cases from 2 tertiary women's health centers. Hum Pathol. 44(9):1877-81, 2013
                                68. Villa A et al: Flat epithelial atypia: comparison between 9-gauge and 11-gauge devices. Clin Breast Cancer. 13(6):450-4, 2013
                                69. Villa A et al: Flat epithelial atypia: comparison between 9-gauge and 11-gauge devices. Clin Breast Cancer. 13(6):450-4, 2013
                                70. Georgian-Smith D et al: Variations in physician recommendations for surgery after diagnosis of a high-risk lesion on breast core needle biopsy. AJR Am J Roentgenol. 198(2):256-63, 2012
                                71. Georgian-Smith D et al: Variations in physician recommendations for surgery after diagnosis of a high-risk lesion on breast core needle biopsy. AJR Am J Roentgenol. 198(2):256-63, 2012
                                72. Heller SL et al: Imaging features and management of high-risk lesions on contrast-enhanced dynamic breast MRI. AJR Am J Roentgenol. 198(2):249-55, 2012
                                73. Heller SL et al: Imaging features and management of high-risk lesions on contrast-enhanced dynamic breast MRI. AJR Am J Roentgenol. 198(2):249-55, 2012
                                74. Krishnamurthy S et al: Multidisciplinary considerations in the management of high-risk breast lesions. AJR Am J Roentgenol. 198(2):W132-40, 2012
                                75. Krishnamurthy S et al: Multidisciplinary considerations in the management of high-risk breast lesions. AJR Am J Roentgenol. 198(2):W132-40, 2012
                                76. Crystal P et al: High-risk lesions diagnosed at MRI-guided vacuum-assisted breast biopsy: can underestimation be predicted? Eur Radiol. 21(3):582-9, 2011
                                77. Crystal P et al: High-risk lesions diagnosed at MRI-guided vacuum-assisted breast biopsy: can underestimation be predicted? Eur Radiol. 21(3):582-9, 2011
                                78. Lavoué V et al: Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat. 125(1):121-6, 2011
                                79. Lavoué V et al: Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat. 125(1):121-6, 2011
                                80. Rajan S et al: What is the significance of flat epithelial atypia and what are the management implications? J Clin Pathol. 64(11):1001-4, 2011
                                81. Rajan S et al: What is the significance of flat epithelial atypia and what are the management implications? J Clin Pathol. 64(11):1001-4, 2011
                                82. Solorzano S et al: Flat epithelial atypia of the breast: pathological-radiological correlation. AJR Am J Roentgenol. 197(3):740-6, 2011
                                83. Solorzano S et al: Flat epithelial atypia of the breast: pathological-radiological correlation. AJR Am J Roentgenol. 197(3):740-6, 2011
                                84. Sudarshan M et al: Flat epithelial atypia of the breast: characteristics and behaviors. Am J Surg. 201(2):245-50, 2011
                                85. Sudarshan M et al: Flat epithelial atypia of the breast: characteristics and behaviors. Am J Surg. 201(2):245-50, 2011
                                86. Adams AL: Flat epithelia atypia: a review of current concepts. The Open Breast Cancer Journal. 2:90-94, 2010
                                87. Adams AL: Flat epithelia atypia: a review of current concepts. The Open Breast Cancer Journal. 2:90-94, 2010
                                88. Georgian-Smith D et al: Controversies on the management of high-risk lesions at core biopsy from a radiology/pathology perspective. Radiol Clin North Am. 48(5):999-1012, 2010
                                89. Georgian-Smith D et al: Controversies on the management of high-risk lesions at core biopsy from a radiology/pathology perspective. Radiol Clin North Am. 48(5):999-1012, 2010
                                90. Moinfar F: Flat ductal intraepithelial neoplasia of the breast: evolution of Azzopardi's "clinging" concept. Semin Diagn Pathol. 27(1):37-48, 2010
                                91. Moinfar F: Flat ductal intraepithelial neoplasia of the breast: evolution of Azzopardi's "clinging" concept. Semin Diagn Pathol. 27(1):37-48, 2010
                                92. Noske A et al: Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology. Hum Pathol. 41(4):522-7, 2010
                                93. Noske A et al: Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology. Hum Pathol. 41(4):522-7, 2010
                                94. Tozaki M et al: Magnetic resonance-guided vacuum-assisted breast biopsy: results in 100 Japanese women. Jpn J Radiol. 28(7):527-33, 2010
                                95. Tozaki M et al: Magnetic resonance-guided vacuum-assisted breast biopsy: results in 100 Japanese women. Jpn J Radiol. 28(7):527-33, 2010
                                96. Moinfar F. Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance--it is time to appreciate the Azzopardi concept! Arch Pathol Lab Med. 133(6):879-92, 2009
                                97. Moinfar F. Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance--it is time to appreciate the Azzopardi concept! Arch Pathol Lab Med. 133(6):879-92, 2009
                                98. Brandt SM et al: The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions. Adv Anat Pathol. 15(3):140-6, 2008
                                99. Brandt SM et al: The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions. Adv Anat Pathol. 15(3):140-6, 2008
                                100. Lerwill MF: Flat epithelial atypia of the breast. Arch Pathol Lab Med. 132(4):615-21, 2008
                                101. Lerwill MF: Flat epithelial atypia of the breast. Arch Pathol Lab Med. 132(4):615-21, 2008
                                102. Collins LC et al: Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients. Mod Pathol. 20(11):1149-55, 2007
                                103. Collins LC et al: Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients. Mod Pathol. 20(11):1149-55, 2007
                                104. Martel M et al: Flat DIN 1 (flat epithelial atypia) on core needle biopsy: 63 cases identified retrospectively among 1,751 core biopsies performed over an 8-year period (1992-1999). Virchows Arch. 451(5):883-91, 2007
                                105. Martel M et al: Flat DIN 1 (flat epithelial atypia) on core needle biopsy: 63 cases identified retrospectively among 1,751 core biopsies performed over an 8-year period (1992-1999). Virchows Arch. 451(5):883-91, 2007
                                106. Pandey S et al: Columnar cell lesions of the breast: mammographic findings with histopathologic correlation. Radiographics. 27 Suppl 1:S79-89, 2007
                                107. Pandey S et al: Columnar cell lesions of the breast: mammographic findings with histopathologic correlation. Radiographics. 27 Suppl 1:S79-89, 2007
                                108. David N et al: [Diagnosis of flat epithelial atypia (FEA) after stereotactic vacuum-assisted biopsy (VAB) of the breast: What is the best management: systematic surgery for all or follow-up?.] J Radiol. 87(11 Pt 1):1671-7, 2006
                                109. David N et al: [Diagnosis of flat epithelial atypia (FEA) after stereotactic vacuum-assisted biopsy (VAB) of the breast: What is the best management: systematic surgery for all or follow-up?.] J Radiol. 87(11 Pt 1):1671-7, 2006
                                110. Berg WA: Image-guided breast biopsy and management of high-risk lesions. Radiol Clin North Am. 42(5):935-46, vii, 2004
                                111. Berg WA: Image-guided breast biopsy and management of high-risk lesions. Radiol Clin North Am. 42(5):935-46, vii, 2004
                                112. Bratthauer GL et al: Assessment of lesions coexisting with various grades of ductal intraepithelial neoplasia of the breast. Virchows Arch. 444(4):340-4, 2004
                                113. Bratthauer GL et al: Assessment of lesions coexisting with various grades of ductal intraepithelial neoplasia of the breast. Virchows Arch. 444(4):340-4, 2004
                                114. Sewell CW: Pathology of high-risk breast lesions and ductal carcinoma in situ. Radiol Clin North Am. 42(5):821-30, v, 2004
                                115. Sewell CW: Pathology of high-risk breast lesions and ductal carcinoma in situ. Radiol Clin North Am. 42(5):821-30, v, 2004
                                116. Schnitt SJ: The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. Breast Cancer Res. 5(5):263-8, 2003
                                117. Schnitt SJ: The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. Breast Cancer Res. 5(5):263-8, 2003
                                118. Tavassoli FA et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003
                                119. Tavassoli FA et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003
                                120. Oyama T et al: Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. Breast Cancer. 7(4):326-31, 2000
                                121. Oyama T et al: Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. Breast Cancer. 7(4):326-31, 2000
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Abbreviations

                                            • Flat epithelial atypia (FEA)
                                          • Synonyms

                                            • Columnar cell change (CCC)/hyperplasia (CCH) with atypia
                                            • Columnar alteration with prominent apical snouts and secretions (CAPSS) with atypia
                                            • Clinging carcinoma, monomorphous type
                                            • Ductal intraepithelial neoplasia (DIN), grade 1A, flat monomorphic type
                                            • Atypical cystic lobules
                                          • Definitions

                                            • Columnar cell lesion with cytologic atypia

                                          IMAGING

                                          • General Features

                                            • Mammographic Findings

                                              • Ultrasonographic Findings

                                                • MR Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Hugar SB et al: Isolated flat epithelial atypia on core biopsy is associated with a low risk of upgrade at excision. Am J Clin Pathol. In press, 2019
                                                              2. Chan PMY et al: Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision. Breast. 37:13-17, 2018
                                                              3. Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
                                                              4. Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
                                                              5. McCroskey Z et al: Flat epithelial atypia in directional vacuum-assisted biopsy of breast microcalcifications: surgical excision may not be necessary. Mod Pathol. 31(7):1097-1106, 2018
                                                              6. Ouldamer L et al: All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast. 40:4-9, 2018
                                                              7. Ouldamer L et al: All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision. Breast. 40:4-9, 2018
                                                              8. Schiaffino S et al: Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy. Br J Radiol. 91(1081):20170484, 2018
                                                              9. Schiaffino S et al: Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy. Br J Radiol. 91(1081):20170484, 2018
                                                              10. Usón Junior PLS et al: Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens. Pathol Oncol Res. 24(1):95-99, 2018
                                                              11. Usón Junior PLS et al: Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens. Pathol Oncol Res. 24(1):95-99, 2018
                                                              12. El Khoury M et al: Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? Br J Radiol. 90(1072):20160750, 2017
                                                              13. El Khoury M et al: Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? Br J Radiol. 90(1072):20160750, 2017
                                                              14. Farshid G et al: Contemporary indications for diagnostic open biopsy in women assessed for screen-detected breast lesions: A ten-year, single institution series of 814 consecutive cases. Breast Cancer Res Treat. 162(1):49-58, 2017
                                                              15. Farshid G et al: Contemporary indications for diagnostic open biopsy in women assessed for screen-detected breast lesions: A ten-year, single institution series of 814 consecutive cases. Breast Cancer Res Treat. 162(1):49-58, 2017
                                                              16. Lamb LR et al: Flat Epithelial Atypia: Upgrade Rates and Risk-Stratification Approach to Support Informed Decision Making. J Am Coll Surg. 225(6):696-701, 2017
                                                              17. Lamb LR et al: Flat Epithelial Atypia: Upgrade Rates and Risk-Stratification Approach to Support Informed Decision Making. J Am Coll Surg. 225(6):696-701, 2017
                                                              18. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: A systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                                              19. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: A systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                                              20. Samples LS et al: Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast. 34:34-43, 2017
                                                              21. Samples LS et al: Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast. 34:34-43, 2017
                                                              22. Acott AA et al: Flat epithelial atypia on core needle biopsy, must we surgically excise? Am J Surg. 212(6):1211-1213, 2016
                                                              23. Acott AA et al: Flat epithelial atypia on core needle biopsy, must we surgically excise? Am J Surg. 212(6):1211-1213, 2016
                                                              24. Ahn HS et al: Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound Med Biol. 42(7):1457-63, 2016
                                                              25. Ahn HS et al: Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound Med Biol. 42(7):1457-63, 2016
                                                              26. Berry JS et al: Analysis of Clinical and Pathologic Factors of Pure, Flat Epithelial Atypia on Core Needle Biopsy to Aid in the Decision of Excision or Observation. J Cancer. 7(1):1-6, 2016
                                                              27. Berry JS et al: Analysis of Clinical and Pathologic Factors of Pure, Flat Epithelial Atypia on Core Needle Biopsy to Aid in the Decision of Excision or Observation. J Cancer. 7(1):1-6, 2016
                                                              28. Calhoun BC et al: Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature. Histopathology. 68(1):138-51, 2016
                                                              29. Calhoun BC et al: Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature. Histopathology. 68(1):138-51, 2016
                                                              30. Mooney KL et al: Upgrade rates of high-risk breast lesions diagnosed on core needle biopsy: a single-institution experience and literature review. Mod Pathol. 29(12):1471-1484, 2016
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