Benign tumor of liver caused by hyperplastic response to localized vascular abnormality
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bröker MEE et al: Performance of contrast-enhanced sonography versus MRI with a liver-specific contrast agent for diagnosis of hepatocellular adenoma and focal nodular hyperplasia. AJR Am J Roentgenol. 214(1):81-9, 2020
Fujita N et al: Hyperintense liver masses at hepatobiliary phase gadoxetic acid-enhanced MRI: imaging appearances and clinical importance. Radiographics. 40(1):72-94, 2020
Gatti M et al: Characterization of the arterial enhancement pattern of focal liver lesions by multiple arterial phase magnetic resonance imaging: comparison between hepatocellular carcinoma and focal nodular hyperplasia. Radiol Med. 125(4):348-55, 2020
Nie P et al: A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver. Cancer Imaging. 20(1):20, 2020
Patacsil SJ et al: A review of benign hepatic tumors and their imaging characteristics. Cureus. 12(1):e6813, 2020
Wang DC et al: Characterization of indeterminate liver lesions on CT and MRI with contrast-enhanced ultrasound: what is the evidence? AJR Am J Roentgenol. 1-10, 2020
Zarfati A et al: Management of focal nodular hyperplasia of the liver: experience of 50 pediatric patients in a tertiary center. J Pediatr Surg. 55(9):1885-91, 2020
Campos Amico E et al: Should focal nodular hyperplasia still be operated upon? Analysis of a case series. Dig Dis. 37(4):309-14, 2019
Cannella R et al: Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images. Abdom Radiol (NY). 44(4):1323-30, 2019
Fang C et al: Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability. Pediatr Radiol. 49(1):82-90, 2019
Kim MJ et al: Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma. Eur Radiol. 29(9):5101-10, 2019
Kozaka K et al: Doughnut-like hyperintense nodules on hepatobiliary phase without arterial-phase hyperenhancement in cirrhotic liver: imaging and clinicopathological features. Eur Radiol. 29(12):6489-98, 2019
Laino ME et al: Treatment-related focal nodular hyperplasia mimicking liver metastases. J Pediatr Hematol Oncol. 41(2):138-9, 2019
Taibbi A et al: Focal nodular hyperplasia: a weight-based, intraindividual comparison of gadobenate dimeglumine and gadoxetate disodium-enhanced MRI. Diagn Interv Radiol. 25(2):95-101, 2019
Vanhooymissen IJSML et al: Intrapatient Comparison of the hepatobiliary phase of Gd-BOPTA and Gd-EOB-DTPA in the differentiation of hepatocellular adenoma from focal nodular hyperplasia. J Magn Reson Imaging. 49(3):700-10, 2019
Bröker MEE et al: Growth of focal nodular hyperplasia is not a reason for surgical intervention, but patients should be referred to a tertiary referral centre. World J Surg. 42(5):1506-13, 2018
Kitao A et al: Differentiation Between Hepatocellular Carcinoma Showing Hyperintensity On The Hepatobiliary Phase Of Gadoxetic Acid-enhanced MRI and focal nodular hyperplasia by CT and MRI. AJR Am J Roentgenol. 211(2):347-57, 2018
Burrowes DP et al: Contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 37(5):1388-400, 2017
Chavhan GB et al: Liver Mr imaging in children: current concepts and technique. Radiographics. 36(5):1517-32, 2016
Dioguardi Burgio M et al: Imaging of hepatic focal nodular hyperplasia: pictorial review and diagnostic strategy. Semin Ultrasound CT MR. 37(6):511-24, 2016
Yoneda N et al: Benign Hepatocellular nodules: hepatobiliary phase of gadoxetic acid-enhanced MR imaging based on molecular background. Radiographics. 36(7):2010-27, 2016
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Focal nodular hyperplasia (FNH)
Definitions
Benign tumor of liver caused by hyperplastic response to localized vascular abnormality
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Bröker MEE et al: Performance of contrast-enhanced sonography versus MRI with a liver-specific contrast agent for diagnosis of hepatocellular adenoma and focal nodular hyperplasia. AJR Am J Roentgenol. 214(1):81-9, 2020
Fujita N et al: Hyperintense liver masses at hepatobiliary phase gadoxetic acid-enhanced MRI: imaging appearances and clinical importance. Radiographics. 40(1):72-94, 2020
Gatti M et al: Characterization of the arterial enhancement pattern of focal liver lesions by multiple arterial phase magnetic resonance imaging: comparison between hepatocellular carcinoma and focal nodular hyperplasia. Radiol Med. 125(4):348-55, 2020
Nie P et al: A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver. Cancer Imaging. 20(1):20, 2020
Patacsil SJ et al: A review of benign hepatic tumors and their imaging characteristics. Cureus. 12(1):e6813, 2020
Wang DC et al: Characterization of indeterminate liver lesions on CT and MRI with contrast-enhanced ultrasound: what is the evidence? AJR Am J Roentgenol. 1-10, 2020
Zarfati A et al: Management of focal nodular hyperplasia of the liver: experience of 50 pediatric patients in a tertiary center. J Pediatr Surg. 55(9):1885-91, 2020
Campos Amico E et al: Should focal nodular hyperplasia still be operated upon? Analysis of a case series. Dig Dis. 37(4):309-14, 2019
Cannella R et al: Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images. Abdom Radiol (NY). 44(4):1323-30, 2019
Fang C et al: Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability. Pediatr Radiol. 49(1):82-90, 2019
Kim MJ et al: Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma. Eur Radiol. 29(9):5101-10, 2019
Kozaka K et al: Doughnut-like hyperintense nodules on hepatobiliary phase without arterial-phase hyperenhancement in cirrhotic liver: imaging and clinicopathological features. Eur Radiol. 29(12):6489-98, 2019
Laino ME et al: Treatment-related focal nodular hyperplasia mimicking liver metastases. J Pediatr Hematol Oncol. 41(2):138-9, 2019
Taibbi A et al: Focal nodular hyperplasia: a weight-based, intraindividual comparison of gadobenate dimeglumine and gadoxetate disodium-enhanced MRI. Diagn Interv Radiol. 25(2):95-101, 2019
Vanhooymissen IJSML et al: Intrapatient Comparison of the hepatobiliary phase of Gd-BOPTA and Gd-EOB-DTPA in the differentiation of hepatocellular adenoma from focal nodular hyperplasia. J Magn Reson Imaging. 49(3):700-10, 2019
Bröker MEE et al: Growth of focal nodular hyperplasia is not a reason for surgical intervention, but patients should be referred to a tertiary referral centre. World J Surg. 42(5):1506-13, 2018
Kitao A et al: Differentiation Between Hepatocellular Carcinoma Showing Hyperintensity On The Hepatobiliary Phase Of Gadoxetic Acid-enhanced MRI and focal nodular hyperplasia by CT and MRI. AJR Am J Roentgenol. 211(2):347-57, 2018
Burrowes DP et al: Contrast-enhanced US approach to the diagnosis of focal liver masses. Radiographics. 37(5):1388-400, 2017
Chavhan GB et al: Liver Mr imaging in children: current concepts and technique. Radiographics. 36(5):1517-32, 2016
Dioguardi Burgio M et al: Imaging of hepatic focal nodular hyperplasia: pictorial review and diagnostic strategy. Semin Ultrasound CT MR. 37(6):511-24, 2016
Yoneda N et al: Benign Hepatocellular nodules: hepatobiliary phase of gadoxetic acid-enhanced MR imaging based on molecular background. Radiographics. 36(7):2010-27, 2016
Cogley JR et al: MR imaging of benign focal liver lesions. Radiol Clin North Am. 52(4):657-82, 2014
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