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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Focal nodular hyperplasia (FNH)
Definitions
- Benign tumor of liver caused by hyperplastic response to localized vascular abnormality
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Kong WT et al: Contrast-enhanced ultrasound in combination with color Doppler ultrasound can improve the diagnostic performance of focal nodular hyperplasia and hepatocellular adenoma. Ultrasound Med Biol. 41(4):944-51, 2015
- Li W et al: Differentiation of atypical hepatocellular carcinoma from focal nodular hyperplasia: diagnostic performance of contrast-enhanced US and microflow imaging. Radiology. 140911, 2015
- Suh CH et al: The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis. Eur Radiol. 25(4):950-60, 2015
- Bertin C et al: Contrast-enhanced ultrasound of focal nodular hyperplasia: a matter of size. Eur Radiol. 24(10):2561-71, 2014
- Cristiano A et al: Focal nodular hyperplasia and hepatic adenoma: current diagnosis and management. Updates Surg. Epub ahead of print, 2013
- Pei XQ et al: Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma. Br J Radiol. 86(1023):20120536, 2013
- Wang W et al: Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT. Eur Radiol. 23(9):2546-54, 2013
- Bonder A et al: Evaluation of liver lesions. Clin Liver Dis. 16(2):271-83, 2012
- Wu S et al: The frequency and clinical significance of the halo sign in focal nodular hyperplasia of the liver. Med Ultrason. 14(4):278-82, 2012
- Quaia E: The real capabilities of contrast-enhanced ultrasound in the characterization of solid focal liver lesions. Eur Radiol. 21(3):457-62, 2011
- Piscaglia F et al: Characterization of focal liver lesions with contrast-enhanced ultrasound. Ultrasound Med Biol. 36(4):531-50, 2010
- Piscaglia F et al: Diagnostic features of real-time contrast-enhanced ultrasound in focal nodular hyperplasia of the liver. Ultraschall Med. 31(3):276-82, 2010
- Seitz K et al: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. Ultraschall Med. 31(5):492-9, 2010
- van den Esschert JW et al: Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma. Dig Surg. 27(1):46-55, 2010
- Jang HJ et al: Contrast-enhanced ultrasound in the detection and characterization of liver tumors. Cancer Imaging. 9:96-103, 2009
- Kamaya A et al: Hypervascular liver lesions. Semin Ultrasound CT MR. 30(5):387-407, 2009
- Trillaud H et al: Characterization of focal liver lesions with SonoVue-enhanced sonography: international multicenter-study in comparison to CT and MRI. World J Gastroenterol. 15(30):3748-56, 2009
- Xu HX et al: Characterization of small focal liver lesions using real-time contrast-enhanced sonography: diagnostic performance analysis in 200 patients. J Ultrasound Med. 25(3):349-61, 2006
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Focal nodular hyperplasia (FNH)
Definitions
- Benign tumor of liver caused by hyperplastic response to localized vascular abnormality
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Kong WT et al: Contrast-enhanced ultrasound in combination with color Doppler ultrasound can improve the diagnostic performance of focal nodular hyperplasia and hepatocellular adenoma. Ultrasound Med Biol. 41(4):944-51, 2015
- Li W et al: Differentiation of atypical hepatocellular carcinoma from focal nodular hyperplasia: diagnostic performance of contrast-enhanced US and microflow imaging. Radiology. 140911, 2015
- Suh CH et al: The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis. Eur Radiol. 25(4):950-60, 2015
- Bertin C et al: Contrast-enhanced ultrasound of focal nodular hyperplasia: a matter of size. Eur Radiol. 24(10):2561-71, 2014
- Cristiano A et al: Focal nodular hyperplasia and hepatic adenoma: current diagnosis and management. Updates Surg. Epub ahead of print, 2013
- Pei XQ et al: Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma. Br J Radiol. 86(1023):20120536, 2013
- Wang W et al: Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT. Eur Radiol. 23(9):2546-54, 2013
- Bonder A et al: Evaluation of liver lesions. Clin Liver Dis. 16(2):271-83, 2012
- Wu S et al: The frequency and clinical significance of the halo sign in focal nodular hyperplasia of the liver. Med Ultrason. 14(4):278-82, 2012
- Quaia E: The real capabilities of contrast-enhanced ultrasound in the characterization of solid focal liver lesions. Eur Radiol. 21(3):457-62, 2011
- Piscaglia F et al: Characterization of focal liver lesions with contrast-enhanced ultrasound. Ultrasound Med Biol. 36(4):531-50, 2010
- Piscaglia F et al: Diagnostic features of real-time contrast-enhanced ultrasound in focal nodular hyperplasia of the liver. Ultraschall Med. 31(3):276-82, 2010
- Seitz K et al: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. Ultraschall Med. 31(5):492-9, 2010
- van den Esschert JW et al: Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma. Dig Surg. 27(1):46-55, 2010
- Jang HJ et al: Contrast-enhanced ultrasound in the detection and characterization of liver tumors. Cancer Imaging. 9:96-103, 2009
- Kamaya A et al: Hypervascular liver lesions. Semin Ultrasound CT MR. 30(5):387-407, 2009
- Trillaud H et al: Characterization of focal liver lesions with SonoVue-enhanced sonography: international multicenter-study in comparison to CT and MRI. World J Gastroenterol. 15(30):3748-56, 2009
- Xu HX et al: Characterization of small focal liver lesions using real-time contrast-enhanced sonography: diagnostic performance analysis in 200 patients. J Ultrasound Med. 25(3):349-61, 2006
