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Frontal Pole (Area 10)
Jeffrey S. Anderson, MD, PhD; Jared A. Nielsen, PhD
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TERMINOLOGY

  • Abbreviations

    • Frontal pole (Fp)

Location and Boundaries

  • Location

    • Boundaries

      Function

      • Fp1

        • Fp2

          • Frontal Pole Function

            • Comparative Anatomy

              • Abstraction

                Structural Connections

                • Tracer/Diffusion Tensor Imaging Studies

                  Functional Connections

                  • Coactive Regions

                    • Associated Literature Keywords (NeuroSynth)

                      Area 10-Associated Disorders

                      • Anterior Cerebral Artery Ischemia

                        • Traumatic Injury

                          Selected References

                          1. Eickhoff SB et al: Topographic organization of the cerebral cortex and brain cartography. Neuroimage. 170:332-47, 2018
                          2. Mansouri FA et al: Managing competing goals - a key role for the frontopolar cortex. Nat Rev Neurosci. 18(11):645-57, 2017
                          3. Glasser MF et al: A multi-modal parcellation of human cerebral cortex. Nature. 536(7615):171-8, 2016
                          4. Mansouri FA et al: Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A. 112(29):E3940-9, 2015
                          5. Neubert FX et al: Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex. Proc Natl Acad Sci U S A. 112(20):E2695-704, 2015
                          6. Orr JM et al: Organization of the human frontal pole revealed by large-scale DTI-based connectivity: implications for control of behavior. PLoS One. 10(5):e0124797, 2015
                          7. Bludau S et al: Cytoarchitecture, probability maps and functions of the human frontal pole. Neuroimage. 93 Pt 2:260-75, 2014
                          8. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                          9. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                          10. Semendeferi K et al: Spatial organization of neurons in the frontal pole sets humans apart from great apes. Cereb Cortex. 21(7):1485-97, 2011
                          11. Tsujimoto S et al: Frontal pole cortex: encoding ends at the end of the endbrain. Trends Cogn Sci. 15(4):169-76, 2011
                          12. Burgess PW et al: The gateway hypothesis of rostral prefrontal cortex (area 10) function. Trends Cogn Sci. 11(7):290-8, 2007
                          13. John JP et al: A proposal for MRI-based parcellation of the frontal pole. Brain Struct Funct. 212(3-4):245-53, 2007
                          14. Gilbert SJ et al: Differential functions of lateral and medial rostral prefrontal cortex (area 10) revealed by brain-behavior associations. Cereb Cortex. 16(12):1783-9, 2006
                          15. Gilbert SJ et al: Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis. J Cogn Neurosci. 18(6):932-48, 2006
                          16. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                          17. Okuda J et al: Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes. Neuroimage. 19(4):1369-80, 2003
                          18. Vogeley K et al: Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia. Schizophr Res. 62(1-2):133-40, 2003
                          19. Semendeferi K et al: Prefrontal cortex in humans and apes: a comparative study of area 10. Am J Phys Anthropol. 114(3):224-41, 2001
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          TERMINOLOGY

                          • Abbreviations

                            • Frontal pole (Fp)

                          Location and Boundaries

                          • Location

                            • Boundaries

                              Function

                              • Fp1

                                • Fp2

                                  • Frontal Pole Function

                                    • Comparative Anatomy

                                      • Abstraction

                                        Structural Connections

                                        • Tracer/Diffusion Tensor Imaging Studies

                                          Functional Connections

                                          • Coactive Regions

                                            • Associated Literature Keywords (NeuroSynth)

                                              Area 10-Associated Disorders

                                              • Anterior Cerebral Artery Ischemia

                                                • Traumatic Injury

                                                  Selected References

                                                  1. Eickhoff SB et al: Topographic organization of the cerebral cortex and brain cartography. Neuroimage. 170:332-47, 2018
                                                  2. Mansouri FA et al: Managing competing goals - a key role for the frontopolar cortex. Nat Rev Neurosci. 18(11):645-57, 2017
                                                  3. Glasser MF et al: A multi-modal parcellation of human cerebral cortex. Nature. 536(7615):171-8, 2016
                                                  4. Mansouri FA et al: Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A. 112(29):E3940-9, 2015
                                                  5. Neubert FX et al: Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex. Proc Natl Acad Sci U S A. 112(20):E2695-704, 2015
                                                  6. Orr JM et al: Organization of the human frontal pole revealed by large-scale DTI-based connectivity: implications for control of behavior. PLoS One. 10(5):e0124797, 2015
                                                  7. Bludau S et al: Cytoarchitecture, probability maps and functions of the human frontal pole. Neuroimage. 93 Pt 2:260-75, 2014
                                                  8. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                                                  9. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                                                  10. Semendeferi K et al: Spatial organization of neurons in the frontal pole sets humans apart from great apes. Cereb Cortex. 21(7):1485-97, 2011
                                                  11. Tsujimoto S et al: Frontal pole cortex: encoding ends at the end of the endbrain. Trends Cogn Sci. 15(4):169-76, 2011
                                                  12. Burgess PW et al: The gateway hypothesis of rostral prefrontal cortex (area 10) function. Trends Cogn Sci. 11(7):290-8, 2007
                                                  13. John JP et al: A proposal for MRI-based parcellation of the frontal pole. Brain Struct Funct. 212(3-4):245-53, 2007
                                                  14. Gilbert SJ et al: Differential functions of lateral and medial rostral prefrontal cortex (area 10) revealed by brain-behavior associations. Cereb Cortex. 16(12):1783-9, 2006
                                                  15. Gilbert SJ et al: Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis. J Cogn Neurosci. 18(6):932-48, 2006
                                                  16. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                                                  17. Okuda J et al: Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes. Neuroimage. 19(4):1369-80, 2003
                                                  18. Vogeley K et al: Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia. Schizophr Res. 62(1-2):133-40, 2003
                                                  19. Semendeferi K et al: Prefrontal cortex in humans and apes: a comparative study of area 10. Am J Phys Anthropol. 114(3):224-41, 2001