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Frontotemporal Dementia
Akiva Mintz, MD, PhD, MHA, CFA; Bryan J. Neth, BS
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Frontotemporal dementia (FTD)
          • Definitions

            • Progressive neurodegenerative disorder of frontal/anterior temporal lobes
              • Commonly characterized by behavioral/personality changes and impairments in other cognitive domains leading to functional decline
              • Previously referred to as Pick disease
                • Now only used to describe pathologically confirmed cases with Pick bodies

          IMAGING

          • Imaging Recommendations

            • Nuclear Medicine Findings

              • Artifacts and Quality Control

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              • Image Interpretation Pearls

                                Selected References

                                1. Wilson H et al: Dementia spectrum disorders: lessons learnt from decades with PET research. J Neural Transm (Vienna). 126(3):233-51, 2019
                                2. Vijverberg EG et al: Diagnostic accuracy of MRI and additional [18F]FDG-PET for behavioral variant frontotemporal dementia in patients with late onset behavioral changes. J Alzheimers Dis. 53(4):1287-97, 2016
                                3. Brown RK et al: Brain PET in suspected dementia: patterns of altered FDG metabolism. Radiographics. 34(3):684-701, 2014
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Frontotemporal dementia (FTD)
                                        • Definitions

                                          • Progressive neurodegenerative disorder of frontal/anterior temporal lobes
                                            • Commonly characterized by behavioral/personality changes and impairments in other cognitive domains leading to functional decline
                                            • Previously referred to as Pick disease
                                              • Now only used to describe pathologically confirmed cases with Pick bodies

                                        IMAGING

                                        • Imaging Recommendations

                                          • Nuclear Medicine Findings

                                            • Artifacts and Quality Control

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          DIAGNOSTIC CHECKLIST

                                                          • Consider

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Wilson H et al: Dementia spectrum disorders: lessons learnt from decades with PET research. J Neural Transm (Vienna). 126(3):233-51, 2019
                                                              2. Vijverberg EG et al: Diagnostic accuracy of MRI and additional [18F]FDG-PET for behavioral variant frontotemporal dementia in patients with late onset behavioral changes. J Alzheimers Dis. 53(4):1287-97, 2016
                                                              3. Brown RK et al: Brain PET in suspected dementia: patterns of altered FDG metabolism. Radiographics. 34(3):684-701, 2014