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Fungal and Miscellaneous Osteomyelitis
Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Fungal spondylodiscitis
              • Definitions

                • Noncaseating, acid-fast negative or fungal infections primarily occurring as opportunistic infections in immunocompromised patients
                  • Involvement of spine and adjacent soft tissue typically secondary to fungal pathogen

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Bakhsh WR et al: Mycobacterium kansasii infection of the spine in a patient with sarcoidosis: a case report and literature review. J Surg Orthop Adv. 23(3):162-5, 2014
                                        2. Raj KA et al: A rare case of spontaneous Aspergillus spondylodiscitis with epidural abscess in a 45-year-old immunocompetent female. J Craniovertebr Junction Spine. 4(2):82-4, 2013
                                        3. B N N et al: Vertebral osteomyelitis with a rare etiology diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 38(5):360-3, 2010
                                        4. Asano T et al: Fungal thoracic Spondylodiskitis in an immunocompetent 14-year-old girl. J Nippon Med Sch. 76(5):265-7, 2009
                                        5. de Lucas EM et al: CT-guided fine-needle aspiration in vertebral osteomyelitis: true usefulness of a common practice. Clin Rheumatol. 28(3):315-20, 2009
                                        6. Garcia-Vidal C et al: Fungal postoperative spondylodiscitis due to Scedosporium prolificans. Spine J. 9(9):e1-7, 2009
                                        7. Gerlach UA et al: Aspergillus spondylodiscitis after multivisceral transplantation. Ann Transplant. 14(4):52-7, 2009
                                        8. Cha JG et al: Candida albicans osteomyelitis of the cervical spine. Skeletal Radiol. 37(4):347-50, 2008
                                        9. Mahiquez M et al: Nonsurgical treatment of lumbosacral blastomycosis involving L2-S1: a case report. Spine (Phila Pa 1976). 33(13):E442-6, 2008
                                        10. Al-Tawfiq JA et al: Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis. Infection. 35(5):377-82, 2007
                                        11. Chen F et al: Mucormycosis spondylodiscitis after lumbar disc puncture. Eur Spine J. 15(3):370-6, 2006
                                        12. Yung BC et al: Aggressive thoracic actinomycosis complicated by vertebral osteomyelitis and epidural abscess leading to spinal cord compression. Spine (Phila Pa 1976). 25(6):745-8, 2000
                                        13. Hadjipavlou AG et al: Blastomycosis of the lumbar spine: case report and review of the literature, with emphasis on diagnostic laboratory tools and management. Eur Spine J. 7(5):416-21, 1998
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Fungal spondylodiscitis
                                                    • Definitions

                                                      • Noncaseating, acid-fast negative or fungal infections primarily occurring as opportunistic infections in immunocompromised patients
                                                        • Involvement of spine and adjacent soft tissue typically secondary to fungal pathogen

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Bakhsh WR et al: Mycobacterium kansasii infection of the spine in a patient with sarcoidosis: a case report and literature review. J Surg Orthop Adv. 23(3):162-5, 2014
                                                                              2. Raj KA et al: A rare case of spontaneous Aspergillus spondylodiscitis with epidural abscess in a 45-year-old immunocompetent female. J Craniovertebr Junction Spine. 4(2):82-4, 2013
                                                                              3. B N N et al: Vertebral osteomyelitis with a rare etiology diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 38(5):360-3, 2010
                                                                              4. Asano T et al: Fungal thoracic Spondylodiskitis in an immunocompetent 14-year-old girl. J Nippon Med Sch. 76(5):265-7, 2009
                                                                              5. de Lucas EM et al: CT-guided fine-needle aspiration in vertebral osteomyelitis: true usefulness of a common practice. Clin Rheumatol. 28(3):315-20, 2009
                                                                              6. Garcia-Vidal C et al: Fungal postoperative spondylodiscitis due to Scedosporium prolificans. Spine J. 9(9):e1-7, 2009
                                                                              7. Gerlach UA et al: Aspergillus spondylodiscitis after multivisceral transplantation. Ann Transplant. 14(4):52-7, 2009
                                                                              8. Cha JG et al: Candida albicans osteomyelitis of the cervical spine. Skeletal Radiol. 37(4):347-50, 2008
                                                                              9. Mahiquez M et al: Nonsurgical treatment of lumbosacral blastomycosis involving L2-S1: a case report. Spine (Phila Pa 1976). 33(13):E442-6, 2008
                                                                              10. Al-Tawfiq JA et al: Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis. Infection. 35(5):377-82, 2007
                                                                              11. Chen F et al: Mucormycosis spondylodiscitis after lumbar disc puncture. Eur Spine J. 15(3):370-6, 2006
                                                                              12. Yung BC et al: Aggressive thoracic actinomycosis complicated by vertebral osteomyelitis and epidural abscess leading to spinal cord compression. Spine (Phila Pa 1976). 25(6):745-8, 2000
                                                                              13. Hadjipavlou AG et al: Blastomycosis of the lumbar spine: case report and review of the literature, with emphasis on diagnostic laboratory tools and management. Eur Spine J. 7(5):416-21, 1998