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Gallbladder Carcinoma
Maria A. Manning, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Gallbladder carcinoma (GBC)
          • Definitions

            • Uncommon, but lethal malignant epithelial neoplasm arising from gallbladder (GB) mucosa
            • Most common biliary neoplasm, with worst prognosis

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
                                            2. Bray F et al: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394-424, 2018
                                            3. Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
                                            4. Torre LA et al: Worldwide burden of and trends in mortality from gallbladder and other biliary tract cancers. Clin Gastroenterol Hepatol. 16(3):427-37, 2018
                                            5. Lamps LW: Gallbladder and Extrahepatic Bile Ducts. In: Goldblum JR et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 863-71, 2017
                                            6. Kim JH et al: High-resolution sonography for distinguishing neoplastic gallbladder polyps and staging gallbladder cancer. AJR Am J Roentgenol. 204(2):W150-9, 2015
                                            7. Mellnick VM et al: Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. Radiographics. 35(2):387-99, 2015
                                            8. Pitt SC et al: Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann Surg. 260(1):128-33, 2014
                                            9. Runner GJ et al: Gallbladder wall thickening. AJR Am J Roentgenol. 202(1):W1-12, 2014
                                            10. Wernberg JA et al: Gallbladder cancer. Surg Clin North Am. 94(2):343-60, 2014
                                            11. Xu JM et al: Differential diagnosis of gallbladder wall thickening: the usefulness of contrast-enhanced ultrasound. Ultrasound Med Biol. 40(12):2794-804, 2014
                                            12. Cairns V et al: Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps. Arch Surg. 147(12):1078-83, 2012
                                            13. Meacock LM et al: Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol. 83(991):615-27, 2010
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Gallbladder carcinoma (GBC)
                                                    • Definitions

                                                      • Uncommon, but lethal malignant epithelial neoplasm arising from gallbladder (GB) mucosa
                                                      • Most common biliary neoplasm, with worst prognosis

                                                    IMAGING

                                                    • General Features

                                                      • Ultrasonographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
                                                                                      2. Bray F et al: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394-424, 2018
                                                                                      3. Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
                                                                                      4. Torre LA et al: Worldwide burden of and trends in mortality from gallbladder and other biliary tract cancers. Clin Gastroenterol Hepatol. 16(3):427-37, 2018
                                                                                      5. Lamps LW: Gallbladder and Extrahepatic Bile Ducts. In: Goldblum JR et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 863-71, 2017
                                                                                      6. Kim JH et al: High-resolution sonography for distinguishing neoplastic gallbladder polyps and staging gallbladder cancer. AJR Am J Roentgenol. 204(2):W150-9, 2015
                                                                                      7. Mellnick VM et al: Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. Radiographics. 35(2):387-99, 2015
                                                                                      8. Pitt SC et al: Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann Surg. 260(1):128-33, 2014
                                                                                      9. Runner GJ et al: Gallbladder wall thickening. AJR Am J Roentgenol. 202(1):W1-12, 2014
                                                                                      10. Wernberg JA et al: Gallbladder cancer. Surg Clin North Am. 94(2):343-60, 2014
                                                                                      11. Xu JM et al: Differential diagnosis of gallbladder wall thickening: the usefulness of contrast-enhanced ultrasound. Ultrasound Med Biol. 40(12):2794-804, 2014
                                                                                      12. Cairns V et al: Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps. Arch Surg. 147(12):1078-83, 2012
                                                                                      13. Meacock LM et al: Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol. 83(991):615-27, 2010