Uncommon, but lethal malignant epithelial neoplasm arising from gallbladder (GB) mucosa
Most common biliary neoplasm, with worst prognosis
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
Bray F et al: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394-424, 2018
Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
Torre LA et al: Worldwide burden of and trends in mortality from gallbladder and other biliary tract cancers. Clin Gastroenterol Hepatol. 16(3):427-37, 2018
Lamps LW: Gallbladder and Extrahepatic Bile Ducts. In: Goldblum JR et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 863-71, 2017
Kim JH et al: High-resolution sonography for distinguishing neoplastic gallbladder polyps and staging gallbladder cancer. AJR Am J Roentgenol. 204(2):W150-9, 2015
Mellnick VM et al: Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. Radiographics. 35(2):387-99, 2015
Pitt SC et al: Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann Surg. 260(1):128-33, 2014
Runner GJ et al: Gallbladder wall thickening. AJR Am J Roentgenol. 202(1):W1-12, 2014
Wernberg JA et al: Gallbladder cancer. Surg Clin North Am. 94(2):343-60, 2014
Xu JM et al: Differential diagnosis of gallbladder wall thickening: the usefulness of contrast-enhanced ultrasound. Ultrasound Med Biol. 40(12):2794-804, 2014
Cairns V et al: Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps. Arch Surg. 147(12):1078-83, 2012
Meacock LM et al: Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol. 83(991):615-27, 2010
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
Gallbladder carcinoma (GBC)
Definitions
Uncommon, but lethal malignant epithelial neoplasm arising from gallbladder (GB) mucosa
Most common biliary neoplasm, with worst prognosis
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Lopes Vendrami C et al: Gallbladder carcinoma and its differential diagnosis at MRI: what radiologists should know. Radiographics. 41(1):78-95, 2021
Bray F et al: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394-424, 2018
Ratanaprasatporn L et al: Multimodality imaging, including dual-energy CT, in the evaluation of gallbladder disease. Radiographics. 38(1):75-89, 2018
Torre LA et al: Worldwide burden of and trends in mortality from gallbladder and other biliary tract cancers. Clin Gastroenterol Hepatol. 16(3):427-37, 2018
Lamps LW: Gallbladder and Extrahepatic Bile Ducts. In: Goldblum JR et al: Rosai and Ackerman's Surgical Pathology. 11th ed. Elsevier. 863-71, 2017
Kim JH et al: High-resolution sonography for distinguishing neoplastic gallbladder polyps and staging gallbladder cancer. AJR Am J Roentgenol. 204(2):W150-9, 2015
Mellnick VM et al: Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. Radiographics. 35(2):387-99, 2015
Pitt SC et al: Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann Surg. 260(1):128-33, 2014
Runner GJ et al: Gallbladder wall thickening. AJR Am J Roentgenol. 202(1):W1-12, 2014
Wernberg JA et al: Gallbladder cancer. Surg Clin North Am. 94(2):343-60, 2014
Xu JM et al: Differential diagnosis of gallbladder wall thickening: the usefulness of contrast-enhanced ultrasound. Ultrasound Med Biol. 40(12):2794-804, 2014
Cairns V et al: Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps. Arch Surg. 147(12):1078-83, 2012
Meacock LM et al: Evaluation of gallbladder and biliary duct disease using microbubble contrast-enhanced ultrasound. Br J Radiol. 83(991):615-27, 2010
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