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Ganglioglioma
Lubdha M. Shah, MD; Jeffrey S. Ross, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Ganglioglioma (GG)
          • Synonyms

            • Gangliocytoma, ganglioneuroma, neuroastrocytoma
          • Definitions

            • Well-differentiated, slowly growing neuroepithelial tumor, composed of neoplastic, mature ganglion cells in combination with neoplastic glial cells

          IMAGING

          • General Features

            • Imaging Recommendations

              • CT Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Yang C et al: Intramedullary gangliogliomas: clinical features, surgical outcomes, and neuropathic scoliosis. J Neurooncol. 116(1):135-43, 2014
                                      2. Karremann M et al: Anaplastic ganglioglioma in children. J Neurooncol. 92(2):157-63, 2009
                                      3. Lotfinia I et al: 'Intramedullary cervical spinal cord ganglioglioma, review of the literature and therapeutic controversies'. Spinal Cord. 47(1):87-90, 2009
                                      4. Nelson RA et al: Floating-Harbor syndrome and intramedullary spinal cord ganglioglioma: case report and observations from the literature. Am J Med Genet A. 149A(10):2265-9, 2009
                                      5. McGirt MJ et al: Neurological outcome after resection of intramedullary spinal cord tumors in children. Childs Nerv Syst. 24(1):93-7, 2008
                                      6. Tobias ME et al: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst. 24(2):219-23, 2008
                                      7. Amini A et al: Malignant transformation of conus medullaris ganglioglioma: case report. J Neurooncol. 82(3):313-5, 2007
                                      8. Becker AJ et al: Ganglioglioma and gangliocytoma. In WHO Classification of Tumors of the Central Nervous System. Louis D et al. Geneva: WHO Press, 2007
                                      9. Chrétien F et al: A 42-year-old man with a densely vascular spinal mass. Brain Pathol. 17(1):119-21, 2007
                                      10. Shamim EA et al: Intramedullary spinal tumor causing "belly dancer syndrome". Mov Disord. 22(11):1673-4, 2007
                                      11. Costa J et al: Ganglioglioma of conus medullaris. Acta Neurochir (Wien). 148(9):977-80, 2006
                                      12. Karabekir HS et al: Primary spinal anaplastic ganglioglioma. Pediatr Neurosurg. 42(6):374-8, 2006
                                      13. Aslanabadi S et al: Intramedullary spinal cord ganglioglioma presenting with abnormal abdominal wall movement. Case report. Neurosurg Focus. 17(4):ECP2, 2004
                                      14. Blümcke I et al: Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol. 61(7):575-84, 2002
                                      15. Sawin PD et al: Spinal cord ganglioglioma in a child with neurofibromatosis type 2. Case report and literature review. J Neurosurg. 90(2 Suppl):231-3, 1999
                                      16. Patel U et al: MR of spinal cord ganglioglioma. AJNR Am J Neuroradiol. 19(5):879-87, 1998
                                      17. Wacker MR et al: Diffuse leptomeningeal involvement by a ganglioglioma in a child. Case report. J Neurosurg. 77(2):302-6, 1992
                                      18. Cheung YK et al: MRI features of spinal ganglioglioma. Clin Imaging. 15(2):109-12, 1991
                                      19. Kamikaseda K et al: Intramedullary ganglioglioma of spinal cord--case report. Neurol Med Chir (Tokyo). 29(9):838-41, 1989
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Ganglioglioma (GG)
                                              • Synonyms

                                                • Gangliocytoma, ganglioneuroma, neuroastrocytoma
                                              • Definitions

                                                • Well-differentiated, slowly growing neuroepithelial tumor, composed of neoplastic, mature ganglion cells in combination with neoplastic glial cells

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • CT Findings

                                                    • MR Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Yang C et al: Intramedullary gangliogliomas: clinical features, surgical outcomes, and neuropathic scoliosis. J Neurooncol. 116(1):135-43, 2014
                                                                          2. Karremann M et al: Anaplastic ganglioglioma in children. J Neurooncol. 92(2):157-63, 2009
                                                                          3. Lotfinia I et al: 'Intramedullary cervical spinal cord ganglioglioma, review of the literature and therapeutic controversies'. Spinal Cord. 47(1):87-90, 2009
                                                                          4. Nelson RA et al: Floating-Harbor syndrome and intramedullary spinal cord ganglioglioma: case report and observations from the literature. Am J Med Genet A. 149A(10):2265-9, 2009
                                                                          5. McGirt MJ et al: Neurological outcome after resection of intramedullary spinal cord tumors in children. Childs Nerv Syst. 24(1):93-7, 2008
                                                                          6. Tobias ME et al: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst. 24(2):219-23, 2008
                                                                          7. Amini A et al: Malignant transformation of conus medullaris ganglioglioma: case report. J Neurooncol. 82(3):313-5, 2007
                                                                          8. Becker AJ et al: Ganglioglioma and gangliocytoma. In WHO Classification of Tumors of the Central Nervous System. Louis D et al. Geneva: WHO Press, 2007
                                                                          9. Chrétien F et al: A 42-year-old man with a densely vascular spinal mass. Brain Pathol. 17(1):119-21, 2007
                                                                          10. Shamim EA et al: Intramedullary spinal tumor causing "belly dancer syndrome". Mov Disord. 22(11):1673-4, 2007
                                                                          11. Costa J et al: Ganglioglioma of conus medullaris. Acta Neurochir (Wien). 148(9):977-80, 2006
                                                                          12. Karabekir HS et al: Primary spinal anaplastic ganglioglioma. Pediatr Neurosurg. 42(6):374-8, 2006
                                                                          13. Aslanabadi S et al: Intramedullary spinal cord ganglioglioma presenting with abnormal abdominal wall movement. Case report. Neurosurg Focus. 17(4):ECP2, 2004
                                                                          14. Blümcke I et al: Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol. 61(7):575-84, 2002
                                                                          15. Sawin PD et al: Spinal cord ganglioglioma in a child with neurofibromatosis type 2. Case report and literature review. J Neurosurg. 90(2 Suppl):231-3, 1999
                                                                          16. Patel U et al: MR of spinal cord ganglioglioma. AJNR Am J Neuroradiol. 19(5):879-87, 1998
                                                                          17. Wacker MR et al: Diffuse leptomeningeal involvement by a ganglioglioma in a child. Case report. J Neurosurg. 77(2):302-6, 1992
                                                                          18. Cheung YK et al: MRI features of spinal ganglioglioma. Clin Imaging. 15(2):109-12, 1991
                                                                          19. Kamikaseda K et al: Intramedullary ganglioglioma of spinal cord--case report. Neurol Med Chir (Tokyo). 29(9):838-41, 1989