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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Diagnostic Checklist
TERMINOLOGY
Definitions
- Gastric carcinoma (GC)
- Malignancy originating from glandular epithelium (adenocarcinoma) of gastric mucosa
- Histologic types: Intestinal, diffuse, indeterminate types
- Gastrointestinal stromal tumor (GIST)
- Nonepithelial; arises from interstitial cells of Cajal
- Most common mesenchymal neoplasm of GI tract
- GISTs are potentially malignant
- Lesions are stratified according to relative risk of recurrence and metastasis
- Prediction of aggressive behavior (malignancy) is based on tumor size, site, mitotic rate (MR), and presence of metastasis
- Pediatric GIST: Rare; have distinct clinical and pathologic features
- Other gastric cancers: Gastric lymphoma (5%), carcinoid
- Gastric carcinoma (GC)
IMAGING
General Features
Nuclear Medicine Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Findlay JM et al: Routinely staging gastric cancer with 18F-FDG PET-CT detects additional metastases and predicts early recurrence and death after surgery. Eur Radiol. 29(5):2490-8, 2019
- Kwon Y et al: Preoperative assessment of malignant potential of gastrointestinal stromal tumor by dual-time-point 18F-fluorodeoxyglucose positron emission tomography imaging: usefulness of standardized uptake value and retention index. J Cancer Res Ther. 15(1):142-7, 2019
- Yoon JK et al: Clinicopathologic parameters associated with the FDG-avidity in staging of early gastric cancer using 18F-FDG PET. Medicine (Baltimore). 98(31):e16690, 2019
- Zhang S et al: Gastric ulcer mimicking malignancy on FDG PET/CT. Clin Nucl Med. 44(2):142-4, 2019
- Kaneko Y et al: Improving patient selection for 18F-FDG PET scanning in the staging of gastric cancer. J Nucl Med. 56(4):523-9, 2015
- Gastrointestinal stromal tumor. In Edge et al. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer. 175, 2010
- Kochhar R et al: Imaging in gastrointestinal stromal tumours: current status and future directions. Clin Radiol. 65(8):584-92, 2010
- O'Sullivan PJ et al: The imaging features of gastrointestinal stromal tumours. Eur J Radiol. 60(3):431-8, 2006
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Diagnostic Checklist
TERMINOLOGY
Definitions
- Gastric carcinoma (GC)
- Malignancy originating from glandular epithelium (adenocarcinoma) of gastric mucosa
- Histologic types: Intestinal, diffuse, indeterminate types
- Gastrointestinal stromal tumor (GIST)
- Nonepithelial; arises from interstitial cells of Cajal
- Most common mesenchymal neoplasm of GI tract
- GISTs are potentially malignant
- Lesions are stratified according to relative risk of recurrence and metastasis
- Prediction of aggressive behavior (malignancy) is based on tumor size, site, mitotic rate (MR), and presence of metastasis
- Pediatric GIST: Rare; have distinct clinical and pathologic features
- Other gastric cancers: Gastric lymphoma (5%), carcinoid
- Gastric carcinoma (GC)
IMAGING
General Features
Nuclear Medicine Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Findlay JM et al: Routinely staging gastric cancer with 18F-FDG PET-CT detects additional metastases and predicts early recurrence and death after surgery. Eur Radiol. 29(5):2490-8, 2019
- Kwon Y et al: Preoperative assessment of malignant potential of gastrointestinal stromal tumor by dual-time-point 18F-fluorodeoxyglucose positron emission tomography imaging: usefulness of standardized uptake value and retention index. J Cancer Res Ther. 15(1):142-7, 2019
- Yoon JK et al: Clinicopathologic parameters associated with the FDG-avidity in staging of early gastric cancer using 18F-FDG PET. Medicine (Baltimore). 98(31):e16690, 2019
- Zhang S et al: Gastric ulcer mimicking malignancy on FDG PET/CT. Clin Nucl Med. 44(2):142-4, 2019
- Kaneko Y et al: Improving patient selection for 18F-FDG PET scanning in the staging of gastric cancer. J Nucl Med. 56(4):523-9, 2015
- Gastrointestinal stromal tumor. In Edge et al. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer. 175, 2010
- Kochhar R et al: Imaging in gastrointestinal stromal tumours: current status and future directions. Clin Radiol. 65(8):584-92, 2010
- O'Sullivan PJ et al: The imaging features of gastrointestinal stromal tumours. Eur J Radiol. 60(3):431-8, 2006
