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Gastrointestinal Stromal Tumor
Ahmed Ebada Salem, MD; Akram M. Shaaban, MBBCh
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8

OVERVIEW

  • General Comments

    • Classification

      PATHOLOGY

      • Routes of Spread

        • General Features

          • Gross Pathology & Surgical Features

            • Microscopic Features

              IMAGING FINDINGS

              • Detection

                • Staging

                  • Restaging

                    CLINICAL ISSUES

                    • Presentation

                      • Cancer Natural History & Prognosis

                        • Treatment Options

                          REPORTING CHECKLIST

                          • T Staging

                            • N Staging

                              • M Staging

                                • Histologic Evaluation

                                  • Restaging

                                    Selected References

                                    1. Theiss L et al: Gastrointestinal stromal tumors of the stomach and esophagus. Surg Clin North Am. 99(3):543-53, 2019
                                    2. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                    3. Yu MH et al: MRI features of gastrointestinal stromal tumors. AJR Am J Roentgenol. 203(5):980-91, 2014
                                    4. Agaimy A et al: Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients < or = 40 years: an overview based on our case material and the literature. Langenbecks Arch Surg. 394(2):375-81, 2009
                                    5. Wronski M et al: Gastrointestinal stromal tumors: ultrasonographic spectrum of the disease. J Ultrasound Med. 28(7):941-8, 2009
                                    6. Choi H: Response evaluation of gastrointestinal stromal tumors. Oncologist. 13 Suppl 2:4-7, 2008
                                    7. Badalamenti G et al: Gastrointestinal stromal tumors (GISTs): focus on histopathological diagnosis and biomolecular features. Ann Oncol. 18 Suppl 6:vi136-40, 2007
                                    8. Choi H et al: Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol. 25(13):1753-9, 2007
                                    9. Gutierrez JC et al: Optimizing diagnosis, staging, and management of gastrointestinal stromal tumors. J Am Coll Surg. 205(3):479-91 (Quiz 524), 2007
                                    10. Hong X et al: Gastrointestinal stromal tumor: role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib. Radiographics. 26(2):481-95, 2006
                                    11. Rubin BP: Gastrointestinal stromal tumours: an update. Histopathology. 48(1):83-96, 2006
                                    12. Warakaulle DR et al: MDCT appearance of gastrointestinal stromal tumors after therapy with imatinib mesylate. AJR Am J Roentgenol. 186(2):510-5, 2006
                                    13. King DM: The radiology of gastrointestinal stromal tumours (GIST). Cancer Imaging. 5:150-6, 2005
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    OVERVIEW

                                    • General Comments

                                      • Classification

                                        PATHOLOGY

                                        • Routes of Spread

                                          • General Features

                                            • Gross Pathology & Surgical Features

                                              • Microscopic Features

                                                IMAGING FINDINGS

                                                • Detection

                                                  • Staging

                                                    • Restaging

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Cancer Natural History & Prognosis

                                                          • Treatment Options

                                                            REPORTING CHECKLIST

                                                            • T Staging

                                                              • N Staging

                                                                • M Staging

                                                                  • Histologic Evaluation

                                                                    • Restaging

                                                                      Selected References

                                                                      1. Theiss L et al: Gastrointestinal stromal tumors of the stomach and esophagus. Surg Clin North Am. 99(3):543-53, 2019
                                                                      2. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                                                      3. Yu MH et al: MRI features of gastrointestinal stromal tumors. AJR Am J Roentgenol. 203(5):980-91, 2014
                                                                      4. Agaimy A et al: Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients < or = 40 years: an overview based on our case material and the literature. Langenbecks Arch Surg. 394(2):375-81, 2009
                                                                      5. Wronski M et al: Gastrointestinal stromal tumors: ultrasonographic spectrum of the disease. J Ultrasound Med. 28(7):941-8, 2009
                                                                      6. Choi H: Response evaluation of gastrointestinal stromal tumors. Oncologist. 13 Suppl 2:4-7, 2008
                                                                      7. Badalamenti G et al: Gastrointestinal stromal tumors (GISTs): focus on histopathological diagnosis and biomolecular features. Ann Oncol. 18 Suppl 6:vi136-40, 2007
                                                                      8. Choi H et al: Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol. 25(13):1753-9, 2007
                                                                      9. Gutierrez JC et al: Optimizing diagnosis, staging, and management of gastrointestinal stromal tumors. J Am Coll Surg. 205(3):479-91 (Quiz 524), 2007
                                                                      10. Hong X et al: Gastrointestinal stromal tumor: role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib. Radiographics. 26(2):481-95, 2006
                                                                      11. Rubin BP: Gastrointestinal stromal tumours: an update. Histopathology. 48(1):83-96, 2006
                                                                      12. Warakaulle DR et al: MDCT appearance of gastrointestinal stromal tumors after therapy with imatinib mesylate. AJR Am J Roentgenol. 186(2):510-5, 2006
                                                                      13. King DM: The radiology of gastrointestinal stromal tumours (GIST). Cancer Imaging. 5:150-6, 2005