link
Bookmarks
Giant Cell Tumor, Craniovertebral Junction
Cheryl A. Petersilge, MD, MBA
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
0
4
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Giant cell tumor (GCT)
            • Definitions

              • Locally aggressive benign neoplasm composed of osteoclast-like giant cells

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Angiographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Zbojniewicz AM et al: Neoplastic disease of the vertebral column: radiologic-pathologic correlation. Curr Probl Diagn Radiol. 39(2):74-90, 2010
                                                2. Junming M et al: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976). 33(3):280-8, 2008
                                                3. Luther N et al: Giant cell tumor of the spine. Neurosurg Clin N Am. 19(1):49-55, 2008
                                                4. Kwon JW et al: MRI findings of giant cell tumors of the spine. AJR Am J Roentgenol. 189(1):246-50, 2007
                                                5. Bertoni F et al: Malignancy in giant cell tumor of bone. Cancer. 97(10):2520-9, 2003
                                                6. Garcia-Bravo A et al: Secondary tetraplegia due to giant-cell tumors of the cervical spine. Neurochirurgie. 48(6):527-32, 2002
                                                7. Murphey MD et al: From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 21(5):1283-309, 2001
                                                8. Lee JA et al: Giant cell tumor of the skull. Radiographics. 18(5):1295-302, 1998
                                                9. Manaster BJ et al: Giant cell tumors of bone. Radiol Clin North Am. 31(2):299-323, 1993
                                                10. Schütte HE et al: Giant cell tumor in children and adolescents. Skeletal Radiol. 22(3):173-6, 1993
                                                11. Tubbs WS et al: Benign giant-cell tumor of bone with pulmonary metastases: clinical findings and radiologic appearance of metastases in 13 cases. AJR Am J Roentgenol. 158(2):331-4, 1992
                                                12. Aoki J et al: Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation. J Comput Assist Tomogr. 15(6):1024-7, 1991
                                                13. Bridge JA et al: Cytogenetic findings and biologic behavior of giant cell tumors of bone. Cancer. 65(12):2697-703, 1990
                                                14. Carrasco CH et al: Giant cell tumors. Orthop Clin North Am. 20(3):395-405, 1989
                                                15. Meis JM et al: Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. Mod Pathol. 2(5):541-6, 1989
                                                16. Mirra JM et al: Bone Tumors: Clinical, Radiologic and Pathologic correlations. Vol. 1. 2nd ed. Philadelphia: Lea & Feibiger. 942-1019, 1989
                                                17. Wolfe JT 3rd et al: Giant-cell tumor of the sphenoid bone. Review of 10 cases. J Neurosurg. 59(2):322-7, 1983
                                                Related Anatomy
                                                Loading...
                                                Related Differential Diagnoses
                                                Loading...
                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Giant cell tumor (GCT)
                                                          • Definitions

                                                            • Locally aggressive benign neoplasm composed of osteoclast-like giant cells

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Angiographic Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Zbojniewicz AM et al: Neoplastic disease of the vertebral column: radiologic-pathologic correlation. Curr Probl Diagn Radiol. 39(2):74-90, 2010
                                                                                              2. Junming M et al: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976). 33(3):280-8, 2008
                                                                                              3. Luther N et al: Giant cell tumor of the spine. Neurosurg Clin N Am. 19(1):49-55, 2008
                                                                                              4. Kwon JW et al: MRI findings of giant cell tumors of the spine. AJR Am J Roentgenol. 189(1):246-50, 2007
                                                                                              5. Bertoni F et al: Malignancy in giant cell tumor of bone. Cancer. 97(10):2520-9, 2003
                                                                                              6. Garcia-Bravo A et al: Secondary tetraplegia due to giant-cell tumors of the cervical spine. Neurochirurgie. 48(6):527-32, 2002
                                                                                              7. Murphey MD et al: From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 21(5):1283-309, 2001
                                                                                              8. Lee JA et al: Giant cell tumor of the skull. Radiographics. 18(5):1295-302, 1998
                                                                                              9. Manaster BJ et al: Giant cell tumors of bone. Radiol Clin North Am. 31(2):299-323, 1993
                                                                                              10. Schütte HE et al: Giant cell tumor in children and adolescents. Skeletal Radiol. 22(3):173-6, 1993
                                                                                              11. Tubbs WS et al: Benign giant-cell tumor of bone with pulmonary metastases: clinical findings and radiologic appearance of metastases in 13 cases. AJR Am J Roentgenol. 158(2):331-4, 1992
                                                                                              12. Aoki J et al: Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation. J Comput Assist Tomogr. 15(6):1024-7, 1991
                                                                                              13. Bridge JA et al: Cytogenetic findings and biologic behavior of giant cell tumors of bone. Cancer. 65(12):2697-703, 1990
                                                                                              14. Carrasco CH et al: Giant cell tumors. Orthop Clin North Am. 20(3):395-405, 1989
                                                                                              15. Meis JM et al: Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. Mod Pathol. 2(5):541-6, 1989
                                                                                              16. Mirra JM et al: Bone Tumors: Clinical, Radiologic and Pathologic correlations. Vol. 1. 2nd ed. Philadelphia: Lea & Feibiger. 942-1019, 1989
                                                                                              17. Wolfe JT 3rd et al: Giant-cell tumor of the sphenoid bone. Review of 10 cases. J Neurosurg. 59(2):322-7, 1983