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Giant Cell Tumor Tendon Sheath
Catherine C. Roberts, MD; B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Giant cell tumor of tendon sheath (GCTTS)
          • Synonyms

            • Tenosynovial giant cell tumor, localized type; nodular tenosynovitis
          • Definitions

            • Benign synovial proliferation within tendon sheath, most commonly involving fingers
              • Same pathologic entity as pigmented villonodular synovitis (PVNS) but in a different location

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                • Imaging Recommendations

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Palmerini E et al: Tenosynovial giant cell tumour/pigmented villonodular synovitis: Outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer. ePub, 2014
                                          2. Bancroft LW et al: Imaging of benign soft tissue tumors. Semin Musculoskelet Radiol. 17(2):156-67, 2013
                                          3. Zeinstra JS et al: Multifocal giant cell tumor of the tendon sheath: case report and literature review. Skeletal Radiol. 42(3):447-50, 2013
                                          4. Fotiadis E et al: Giant cell tumour of tendon sheath of the digits. A systematic review. Hand (N Y). 6(3):244-9, 2011
                                          5. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                          6. Bancroft LW et al: Imaging of soft tissue lesions of the foot and ankle. Radiol Clin North Am. 46(6):1093-103, vii, 2008
                                          7. Weiss SW et al: Benign tumors and tumor-like lesions of synovial tissue. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 770-7, 2008
                                          8. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 382, 2006
                                          9. Aoki J et al: FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses. Skeletal Radiol. 32(3):133-8, 2003
                                          10. Kitagawa Y et al: MR imaging for preoperative diagnosis and assessment of local tumor extent on localized giant cell tumor of tendon sheath. Skeletal Radiol. 32(11):633-8, 2003
                                          11. de St. Aubain Somerhausen N et al: Giant cell tumour of tendon sheath. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 110-1, 2002
                                          12. Hughes TH et al: Pigmented villonodular synovitis: MRI characteristics. Skeletal Radiol. 24(1):7-12, 1995
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Giant cell tumor of tendon sheath (GCTTS)
                                                  • Synonyms

                                                    • Tenosynovial giant cell tumor, localized type; nodular tenosynovitis
                                                  • Definitions

                                                    • Benign synovial proliferation within tendon sheath, most commonly involving fingers
                                                      • Same pathologic entity as pigmented villonodular synovitis (PVNS) but in a different location

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Palmerini E et al: Tenosynovial giant cell tumour/pigmented villonodular synovitis: Outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer. ePub, 2014
                                                                                  2. Bancroft LW et al: Imaging of benign soft tissue tumors. Semin Musculoskelet Radiol. 17(2):156-67, 2013
                                                                                  3. Zeinstra JS et al: Multifocal giant cell tumor of the tendon sheath: case report and literature review. Skeletal Radiol. 42(3):447-50, 2013
                                                                                  4. Fotiadis E et al: Giant cell tumour of tendon sheath of the digits. A systematic review. Hand (N Y). 6(3):244-9, 2011
                                                                                  5. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                                                                  6. Bancroft LW et al: Imaging of soft tissue lesions of the foot and ankle. Radiol Clin North Am. 46(6):1093-103, vii, 2008
                                                                                  7. Weiss SW et al: Benign tumors and tumor-like lesions of synovial tissue. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 770-7, 2008
                                                                                  8. Kransdorf MJ et al: Synovial tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 382, 2006
                                                                                  9. Aoki J et al: FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses. Skeletal Radiol. 32(3):133-8, 2003
                                                                                  10. Kitagawa Y et al: MR imaging for preoperative diagnosis and assessment of local tumor extent on localized giant cell tumor of tendon sheath. Skeletal Radiol. 32(11):633-8, 2003
                                                                                  11. de St. Aubain Somerhausen N et al: Giant cell tumour of tendon sheath. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 110-1, 2002
                                                                                  12. Hughes TH et al: Pigmented villonodular synovitis: MRI characteristics. Skeletal Radiol. 24(1):7-12, 1995