link
Bookmarks
Giant Lymph Node Hyperplasia (Castleman Disease)
Luke N. Ledbetter, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
11
12
4

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Castleman disease (CD)
                • Multicentric Castleman disease (MCD)
              • Synonyms

                • Angiofollicular lymphoid hyperplasia, follicular lymphoreticuloma, angiomatous lymphoid hamartoma, lymph nodal hamartoma
              • Definitions

                • Uncommon benign hypervascular nonclonal lymphoproliferative disorder
                  • Clinical subtypes: Unifocal and multicentric (MCD)
                  • Histologic classification
                    • Hyaline vascular (90%)
                    • Plasma cell (< 10%)
                    • Human herpesvirus 8 (HHV-8) related
                    • MCD not otherwise specified

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Hill AJ et al: Multimodality imaging and clinical features in Castleman disease: single institute experience in 30 patients. Br J Radiol. 20140670, 2015
                                                  2. Jiang XH et al: Castleman disease of the neck: CT and MR imaging findings. Eur J Radiol. 83(11):2041-50, 2014
                                                  3. Chen YF et al: Clinical features and outcomes of head and neck castleman disease. J Oral Maxillofac Surg. 70(10):2466-79, 2012
                                                  4. Bonekamp D et al: Castleman disease: the great mimic. Radiographics. 31(6):1793-807, 2011
                                                  5. Barker R et al: FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging. 36(4):648-52, 2009
                                                  6. Cronin DM et al: Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol. 16(4):236-46, 2009
                                                  7. Gupta A et al: Multicentric hyaline-vascular type Castleman disease presenting as an epidural mass causing paraplegia: a case report. Clin Lymphoma Myeloma. 9(3):250-3, 2009
                                                  8. Liang J et al: Cervical unicentric Castleman disease presenting as a neck mass: case report and review of the literature. Ear Nose Throat J. 88(5):E8, 2009
                                                  9. Ozgursoy OB et al: Castleman disease in the parapharyngeal space: unusual presentation and differential diagnostic imaging features of the disease. J Otolaryngol Head Neck Surg. 38(5):E118-20, 2009
                                                  10. Rao HG et al: Unusual location for Castleman's disease. J Laryngol Otol. 123(1):e3, 2009
                                                  11. Barker R et al: Imaging in multicentric Castleman's disease. J HIV Ther. 13(3):72-4, 2008
                                                  12. Flejsierowicz M et al: Successful treatment of aggressive HIV-associated multicentric Castleman's disease: a case report. WMJ. 107(4):191-4, 2008
                                                  13. Park JH et al: Castleman disease of the parotid gland in childhood: an unusual entity. Auris Nasus Larynx. 35(3):451-4, 2008
                                                  14. Souza KC et al: Cervical Castleman's disease in childhood. J Oral Maxillofac Surg. 66(5):1067-72, 2008
                                                  15. Newlon JL et al: Castleman's disease: three case reports and a review of the literature. Ear Nose Throat J. 86(7):414-8, 2007
                                                  16. Taylor N et al: Imaging manifestations of neck masses in the immunocompromised host. Clin Radiol. 62(7):615-25, 2007
                                                  17. Akdogan O et al: Castleman's disease of the bilateral parotid gland: a case report. B-ENT. 2(4):185-7, 2006
                                                  18. Beraldo S et al: Castleman's disease as an uncommon cause of a neck mass. Acta Otolaryngol. 126(1):108-11, 2006
                                                  19. Song JJ et al: Castleman's disease of the head and neck. Eur Arch Otorhinolaryngol. 263(2):160-3, 2006
                                                  20. King AD et al: Human cervical lymphadenopathy: evaluation with in vivo 1H-MRS at 1.5 T. Clin Radiol. 60(5):592-8, 2005
                                                  Related Anatomy
                                                  Loading...
                                                  Related Differential Diagnoses
                                                  Loading...
                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Castleman disease (CD)
                                                                • Multicentric Castleman disease (MCD)
                                                              • Synonyms

                                                                • Angiofollicular lymphoid hyperplasia, follicular lymphoreticuloma, angiomatous lymphoid hamartoma, lymph nodal hamartoma
                                                              • Definitions

                                                                • Uncommon benign hypervascular nonclonal lymphoproliferative disorder
                                                                  • Clinical subtypes: Unifocal and multicentric (MCD)
                                                                  • Histologic classification
                                                                    • Hyaline vascular (90%)
                                                                    • Plasma cell (< 10%)
                                                                    • Human herpesvirus 8 (HHV-8) related
                                                                    • MCD not otherwise specified

                                                              IMAGING

                                                              • General Features

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Hill AJ et al: Multimodality imaging and clinical features in Castleman disease: single institute experience in 30 patients. Br J Radiol. 20140670, 2015
                                                                                                  2. Jiang XH et al: Castleman disease of the neck: CT and MR imaging findings. Eur J Radiol. 83(11):2041-50, 2014
                                                                                                  3. Chen YF et al: Clinical features and outcomes of head and neck castleman disease. J Oral Maxillofac Surg. 70(10):2466-79, 2012
                                                                                                  4. Bonekamp D et al: Castleman disease: the great mimic. Radiographics. 31(6):1793-807, 2011
                                                                                                  5. Barker R et al: FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging. 36(4):648-52, 2009
                                                                                                  6. Cronin DM et al: Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol. 16(4):236-46, 2009
                                                                                                  7. Gupta A et al: Multicentric hyaline-vascular type Castleman disease presenting as an epidural mass causing paraplegia: a case report. Clin Lymphoma Myeloma. 9(3):250-3, 2009
                                                                                                  8. Liang J et al: Cervical unicentric Castleman disease presenting as a neck mass: case report and review of the literature. Ear Nose Throat J. 88(5):E8, 2009
                                                                                                  9. Ozgursoy OB et al: Castleman disease in the parapharyngeal space: unusual presentation and differential diagnostic imaging features of the disease. J Otolaryngol Head Neck Surg. 38(5):E118-20, 2009
                                                                                                  10. Rao HG et al: Unusual location for Castleman's disease. J Laryngol Otol. 123(1):e3, 2009
                                                                                                  11. Barker R et al: Imaging in multicentric Castleman's disease. J HIV Ther. 13(3):72-4, 2008
                                                                                                  12. Flejsierowicz M et al: Successful treatment of aggressive HIV-associated multicentric Castleman's disease: a case report. WMJ. 107(4):191-4, 2008
                                                                                                  13. Park JH et al: Castleman disease of the parotid gland in childhood: an unusual entity. Auris Nasus Larynx. 35(3):451-4, 2008
                                                                                                  14. Souza KC et al: Cervical Castleman's disease in childhood. J Oral Maxillofac Surg. 66(5):1067-72, 2008
                                                                                                  15. Newlon JL et al: Castleman's disease: three case reports and a review of the literature. Ear Nose Throat J. 86(7):414-8, 2007
                                                                                                  16. Taylor N et al: Imaging manifestations of neck masses in the immunocompromised host. Clin Radiol. 62(7):615-25, 2007
                                                                                                  17. Akdogan O et al: Castleman's disease of the bilateral parotid gland: a case report. B-ENT. 2(4):185-7, 2006
                                                                                                  18. Beraldo S et al: Castleman's disease as an uncommon cause of a neck mass. Acta Otolaryngol. 126(1):108-11, 2006
                                                                                                  19. Song JJ et al: Castleman's disease of the head and neck. Eur Arch Otorhinolaryngol. 263(2):160-3, 2006
                                                                                                  20. King AD et al: Human cervical lymphadenopathy: evaluation with in vivo 1H-MRS at 1.5 T. Clin Radiol. 60(5):592-8, 2005