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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Castleman disease (CD)
Synonyms
- Angiofollicular lymphoid hyperplasia, follicular lymphoreticuloma, angiomatous lymphoid hamartoma, lymph nodal hamartoma
Definitions
- Uncommon, benign hypervascular nonclonal lymphoproliferative disorder
- Clinical subtypes: Unifocal and multicentric CD (MCD)
- Histologic classification
- Hyaline vascular (90%)
- Plasma cell (< 10%)
- Human herpesvirus 8 (HHV-8) related
- MCD not otherwise specified
- Uncommon, benign hypervascular nonclonal lymphoproliferative disorder
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Pribyl K et al: Castleman disease: a single-center case series. Int J Surg Case Rep. 80:105650, 2021
- Fujimoto S et al: Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease? Am J Hematol. 94(9):975-83, 2019
- Zhao S et al: Imaging and clinical features of Castleman Disease. Cancer Imaging. 19(1):53, 2019
- Hill AJ et al: Multimodality imaging and clinical features in Castleman disease: single institute experience in 30 patients. Br J Radiol. 20140670, 2015
- Jiang XH et al: Castleman disease of the neck: CT and MR imaging findings. Eur J Radiol. 83(11):2041-50, 2014
- Chen YF et al: Clinical features and outcomes of head and neck castleman disease. J Oral Maxillofac Surg. 70(10):2466-79, 2012
- Bonekamp D et al: Castleman disease: the great mimic. Radiographics. 31(6):1793-807, 2011
- Barker R et al: FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging. 36(4):648-52, 2009
- Cronin DM et al: Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol. 16(4):236-46, 2009
- Gupta A et al: Multicentric hyaline-vascular type Castleman disease presenting as an epidural mass causing paraplegia: a case report. Clin Lymphoma Myeloma. 9(3):250-3, 2009
- Liang J et al: Cervical unicentric Castleman disease presenting as a neck mass: case report and review of the literature. Ear Nose Throat J. 88(5):E8, 2009
- Ozgursoy OB et al: Castleman disease in the parapharyngeal space: unusual presentation and differential diagnostic imaging features of the disease. J Otolaryngol Head Neck Surg. 38(5):E118-20, 2009
- Rao HG et al: Unusual location for Castleman's disease. J Laryngol Otol. 123(1):e3, 2009
- Barker R et al: Imaging in multicentric Castleman's disease. J HIV Ther. 13(3):72-4, 2008
- Flejsierowicz M et al: Successful treatment of aggressive HIV-associated multicentric Castleman's disease: a case report. WMJ. 107(4):191-4, 2008
- Park JH et al: Castleman disease of the parotid gland in childhood: an unusual entity. Auris Nasus Larynx. 35(3):451-4, 2008
- Souza KC et al: Cervical Castleman's disease in childhood. J Oral Maxillofac Surg. 66(5):1067-72, 2008
- Newlon JL et al: Castleman's disease: three case reports and a review of the literature. Ear Nose Throat J. 86(7):414-8, 2007
- Taylor N et al: Imaging manifestations of neck masses in the immunocompromised host. Clin Radiol. 62(7):615-25, 2007
- Akdogan O et al: Castleman's disease of the bilateral parotid gland: a case report. B-ENT. 2(4):185-7, 2006
- Beraldo S et al: Castleman's disease as an uncommon cause of a neck mass. Acta Otolaryngol. 126(1):108-11, 2006
- Song JJ et al: Castleman's disease of the head and neck. Eur Arch Otorhinolaryngol. 263(2):160-3, 2006
- King AD et al: Human cervical lymphadenopathy: evaluation with in vivo 1H-MRS at 1.5 T. Clin Radiol. 60(5):592-8, 2005
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Castleman disease (CD)
Synonyms
- Angiofollicular lymphoid hyperplasia, follicular lymphoreticuloma, angiomatous lymphoid hamartoma, lymph nodal hamartoma
Definitions
- Uncommon, benign hypervascular nonclonal lymphoproliferative disorder
- Clinical subtypes: Unifocal and multicentric CD (MCD)
- Histologic classification
- Hyaline vascular (90%)
- Plasma cell (< 10%)
- Human herpesvirus 8 (HHV-8) related
- MCD not otherwise specified
- Uncommon, benign hypervascular nonclonal lymphoproliferative disorder
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Pribyl K et al: Castleman disease: a single-center case series. Int J Surg Case Rep. 80:105650, 2021
- Fujimoto S et al: Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease? Am J Hematol. 94(9):975-83, 2019
- Zhao S et al: Imaging and clinical features of Castleman Disease. Cancer Imaging. 19(1):53, 2019
- Hill AJ et al: Multimodality imaging and clinical features in Castleman disease: single institute experience in 30 patients. Br J Radiol. 20140670, 2015
- Jiang XH et al: Castleman disease of the neck: CT and MR imaging findings. Eur J Radiol. 83(11):2041-50, 2014
- Chen YF et al: Clinical features and outcomes of head and neck castleman disease. J Oral Maxillofac Surg. 70(10):2466-79, 2012
- Bonekamp D et al: Castleman disease: the great mimic. Radiographics. 31(6):1793-807, 2011
- Barker R et al: FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging. 36(4):648-52, 2009
- Cronin DM et al: Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol. 16(4):236-46, 2009
- Gupta A et al: Multicentric hyaline-vascular type Castleman disease presenting as an epidural mass causing paraplegia: a case report. Clin Lymphoma Myeloma. 9(3):250-3, 2009
- Liang J et al: Cervical unicentric Castleman disease presenting as a neck mass: case report and review of the literature. Ear Nose Throat J. 88(5):E8, 2009
- Ozgursoy OB et al: Castleman disease in the parapharyngeal space: unusual presentation and differential diagnostic imaging features of the disease. J Otolaryngol Head Neck Surg. 38(5):E118-20, 2009
- Rao HG et al: Unusual location for Castleman's disease. J Laryngol Otol. 123(1):e3, 2009
- Barker R et al: Imaging in multicentric Castleman's disease. J HIV Ther. 13(3):72-4, 2008
- Flejsierowicz M et al: Successful treatment of aggressive HIV-associated multicentric Castleman's disease: a case report. WMJ. 107(4):191-4, 2008
- Park JH et al: Castleman disease of the parotid gland in childhood: an unusual entity. Auris Nasus Larynx. 35(3):451-4, 2008
- Souza KC et al: Cervical Castleman's disease in childhood. J Oral Maxillofac Surg. 66(5):1067-72, 2008
- Newlon JL et al: Castleman's disease: three case reports and a review of the literature. Ear Nose Throat J. 86(7):414-8, 2007
- Taylor N et al: Imaging manifestations of neck masses in the immunocompromised host. Clin Radiol. 62(7):615-25, 2007
- Akdogan O et al: Castleman's disease of the bilateral parotid gland: a case report. B-ENT. 2(4):185-7, 2006
- Beraldo S et al: Castleman's disease as an uncommon cause of a neck mass. Acta Otolaryngol. 126(1):108-11, 2006
- Song JJ et al: Castleman's disease of the head and neck. Eur Arch Otorhinolaryngol. 263(2):160-3, 2006
- King AD et al: Human cervical lymphadenopathy: evaluation with in vivo 1H-MRS at 1.5 T. Clin Radiol. 60(5):592-8, 2005
