link
Bookmarks
Gliosarcoma
Karen L. Salzman, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
7
0
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Rare glioblastoma variant with both glial and mesenchymal elements
                • May be primary or secondary (sarcomatous growth in recurrent glioblastoma [GBM])

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. McAleer MF et al: Therapeutic management of gliosarcoma in the temozolomide era. CNS Oncol. 4(3):171-8, 2015
                                            2. Blumenthal DT et al: A Phase III study of radiation therapy (RT) and O<sup>6</sup>-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001. Int J Clin Oncol. ePub, 2014
                                            3. Huo Z et al: Primary gliosarcoma with long-survival: report of two cases and review of literature. Int J Clin Exp Pathol. 7(9):6323-32, 2014
                                            4. Smith AB et al: From the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic-pathologic correlation. Radiographics. 34(2):295-312, 2014
                                            5. Romero-Rojas AE et al: Primary gliosarcoma of the brain: radiologic and histopathologic features. Neuroradiol J. 26(6):639-48, 2013
                                            6. Han SJ et al: Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients. J Neurosurg. 112(5):990-6, 2010
                                            7. Hochwald O et al: Congenital Gliosarcoma: Detailed Clinicopathologic Documentation of a Rare Neoplasm. Pediatr Dev Pathol. Epub ahead of print, 2009
                                            8. Kozak KR et al: Adult gliosarcoma: epidemiology, natural history, and factors associated with outcome. Neuro Oncol. 11(2):183-91, 2009
                                            9. Demirci S et al: Multiple spinal metastases of cranial gliosarcoma: a case report and review of the literature. J Neurooncol. 88(2):199-204, 2008
                                            10. Han L et al: Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases. Acta Radiol. 49(9):1058-67, 2008
                                            11. Kumar P et al: Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. J Cancer Res Ther. 4(4):164-8, 2008
                                            12. Kleihues et al: WHO Classification of Tumours of the Central Nervous System: Gliosarcoma. Lyon: IARC Press. 48-9, 2007
                                            13. Lutterbach J et al: Gliosarcoma: a clinical study. Radiother Oncol. 61(1):57-64, 2001
                                            14. Perry JR et al: Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. Cancer. 75(12):2910-8, 1995
                                            Related Anatomy
                                            Loading...
                                            Related Differential Diagnoses
                                            Loading...
                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Definitions

                                                          • Rare glioblastoma variant with both glial and mesenchymal elements
                                                          • May be primary or secondary (sarcomatous growth in recurrent glioblastoma [GBM])

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. McAleer MF et al: Therapeutic management of gliosarcoma in the temozolomide era. CNS Oncol. 4(3):171-8, 2015
                                                                                      2. Blumenthal DT et al: A Phase III study of radiation therapy (RT) and O<sup>6</sup>-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001. Int J Clin Oncol. ePub, 2014
                                                                                      3. Huo Z et al: Primary gliosarcoma with long-survival: report of two cases and review of literature. Int J Clin Exp Pathol. 7(9):6323-32, 2014
                                                                                      4. Smith AB et al: From the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic-pathologic correlation. Radiographics. 34(2):295-312, 2014
                                                                                      5. Romero-Rojas AE et al: Primary gliosarcoma of the brain: radiologic and histopathologic features. Neuroradiol J. 26(6):639-48, 2013
                                                                                      6. Han SJ et al: Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients. J Neurosurg. 112(5):990-6, 2010
                                                                                      7. Hochwald O et al: Congenital Gliosarcoma: Detailed Clinicopathologic Documentation of a Rare Neoplasm. Pediatr Dev Pathol. Epub ahead of print, 2009
                                                                                      8. Kozak KR et al: Adult gliosarcoma: epidemiology, natural history, and factors associated with outcome. Neuro Oncol. 11(2):183-91, 2009
                                                                                      9. Demirci S et al: Multiple spinal metastases of cranial gliosarcoma: a case report and review of the literature. J Neurooncol. 88(2):199-204, 2008
                                                                                      10. Han L et al: Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases. Acta Radiol. 49(9):1058-67, 2008
                                                                                      11. Kumar P et al: Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. J Cancer Res Ther. 4(4):164-8, 2008
                                                                                      12. Kleihues et al: WHO Classification of Tumours of the Central Nervous System: Gliosarcoma. Lyon: IARC Press. 48-9, 2007
                                                                                      13. Lutterbach J et al: Gliosarcoma: a clinical study. Radiother Oncol. 61(1):57-64, 2001
                                                                                      14. Perry JR et al: Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. Cancer. 75(12):2910-8, 1995