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Glottic Laryngeal Squamous Cell Carcinoma
Surjith Vattoth, MD, FRCR; Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Glottic squamous cell carcinoma (G-SCCa)
            • Definitions

              • SCCa arising on mucosal surface of glottic larynx
                • True vocal cord (TVC), anterior & posterior commissures

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        • Ultrasonographic Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Mannelli G et al: T1 Glottic cancer: does anterior commissure involvement worsen prognosis? Cancers (Basel). 12(6):148, 2020
                                                  2. Bayan S et al: Glottic carcinoma in young patients. Ann Otol Rhinol Laryngol. 128(3_suppl):25S-32S, 2019
                                                  3. Brady JS et al: Survival impact of initial therapy in patients with T1-T2 glottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 155(2):257-64, 2016
                                                  4. Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. 126(8):1817-22, 2016
                                                  5. Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. 38(8):1286-9, 2016
                                                  6. Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
                                                  7. Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
                                                  8. Tibbetts KM et al: Role of advanced laryngeal imaging in glottic cancer: early detection and evaluation of glottic neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
                                                  9. Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
                                                  10. Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
                                                  11. Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
                                                  12. Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
                                                  13. Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
                                                  14. Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
                                                  15. Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
                                                  16. Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
                                                  17. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                  18. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Glottic squamous cell carcinoma (G-SCCa)
                                                            • Definitions

                                                              • SCCa arising on mucosal surface of glottic larynx
                                                                • True vocal cord (TVC), anterior & posterior commissures

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        • Ultrasonographic Findings

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Mannelli G et al: T1 Glottic cancer: does anterior commissure involvement worsen prognosis? Cancers (Basel). 12(6):148, 2020
                                                                                                  2. Bayan S et al: Glottic carcinoma in young patients. Ann Otol Rhinol Laryngol. 128(3_suppl):25S-32S, 2019
                                                                                                  3. Brady JS et al: Survival impact of initial therapy in patients with T1-T2 glottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 155(2):257-64, 2016
                                                                                                  4. Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. 126(8):1817-22, 2016
                                                                                                  5. Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. 38(8):1286-9, 2016
                                                                                                  6. Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
                                                                                                  7. Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
                                                                                                  8. Tibbetts KM et al: Role of advanced laryngeal imaging in glottic cancer: early detection and evaluation of glottic neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
                                                                                                  9. Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
                                                                                                  10. Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
                                                                                                  11. Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
                                                                                                  12. Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
                                                                                                  13. Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
                                                                                                  14. Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
                                                                                                  15. Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
                                                                                                  16. Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
                                                                                                  17. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                                                                  18. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008