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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Glottic squamous cell carcinoma (G-SCCa)
Definitions
- SCCa arising on mucosal surface of glottic larynx
- Vocal cord, anterior and posterior commissures
- SCCa arising on mucosal surface of glottic larynx
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Brady JS et al: Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. ePub, 2016
- Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. ePub, 2016
- Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
- Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
- Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. ePub, 2015
- Tibbetts KM et al: Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
- Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
- Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
- Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
- Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
- Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
- Ansarin M et al: Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg. 135(4):385-90, 2009
- Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
- Hafidh M et al: Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg. 38(4):434-9, 2009
- Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
- Kuribayashi S et al: Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma. J Ultrasound Med. 28(11):1429-40, 2009
- Patel NP et al: Metastatic calcification involving the true vocal cord. Am J Otolaryngol. 30(3):216-8, 2009
- Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
- Rödel RM et al: Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck. 31(5):583-92, 2009
- Sachse F et al: Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck. 31(4):531-7, 2009
- Shvero J et al: T1 glottic carcinoma involving the posterior commissure. Laryngoscope. 119(6):1116-9, 2009
- Sjögren EV et al: Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 266(5):735-44, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Charbonneau N et al: Treatment results of carcinoma in situ of the glottic larynx: 61 patients treated with radiotherapy. J Otolaryngol Head Neck Surg. 37(4):572-6, 2008
- Choong NW et al: Recurrent laryngeal nerve palsy on integrated positron emission tomography-computed tomography. J Thorac Oncol. 3(10):1172, 2008
- Dornfeld K et al: Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys. 71(2):386-92, 2008
- Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
- Kourelis K et al: Glottic versus supraglottic tumors: differential molecular profile. Eur Arch Otorhinolaryngol. 265(1):79-84, 2008
- Nomiya T et al: Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope. 118(8):1417-21, 2008
- Roh JL et al: The utility of second-look operation after laser microresection of glottic carcinoma involving the anterior commissure. Laryngoscope. 118(8):1400-4, 2008
- Liu JC et al: Squamous cell carcinoma masquerading as a vocal fold papilloma. Ear Nose Throat J. 86(10):594, 2007
- Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
- Barthel SW et al: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124(1):35-9, 2001
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Glottic squamous cell carcinoma (G-SCCa)
Definitions
- SCCa arising on mucosal surface of glottic larynx
- Vocal cord, anterior and posterior commissures
- SCCa arising on mucosal surface of glottic larynx
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
Ultrasonographic Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Brady JS et al: Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. ePub, 2016
- Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. ePub, 2016
- Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
- Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
- Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. ePub, 2015
- Tibbetts KM et al: Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
- Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
- Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
- Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
- Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
- Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
- Ansarin M et al: Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg. 135(4):385-90, 2009
- Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
- Hafidh M et al: Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg. 38(4):434-9, 2009
- Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
- Kuribayashi S et al: Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma. J Ultrasound Med. 28(11):1429-40, 2009
- Patel NP et al: Metastatic calcification involving the true vocal cord. Am J Otolaryngol. 30(3):216-8, 2009
- Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
- Rödel RM et al: Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck. 31(5):583-92, 2009
- Sachse F et al: Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck. 31(4):531-7, 2009
- Shvero J et al: T1 glottic carcinoma involving the posterior commissure. Laryngoscope. 119(6):1116-9, 2009
- Sjögren EV et al: Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 266(5):735-44, 2009
- Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
- Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
- Charbonneau N et al: Treatment results of carcinoma in situ of the glottic larynx: 61 patients treated with radiotherapy. J Otolaryngol Head Neck Surg. 37(4):572-6, 2008
- Choong NW et al: Recurrent laryngeal nerve palsy on integrated positron emission tomography-computed tomography. J Thorac Oncol. 3(10):1172, 2008
- Dornfeld K et al: Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys. 71(2):386-92, 2008
- Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
- Kourelis K et al: Glottic versus supraglottic tumors: differential molecular profile. Eur Arch Otorhinolaryngol. 265(1):79-84, 2008
- Nomiya T et al: Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope. 118(8):1417-21, 2008
- Roh JL et al: The utility of second-look operation after laser microresection of glottic carcinoma involving the anterior commissure. Laryngoscope. 118(8):1400-4, 2008
- Liu JC et al: Squamous cell carcinoma masquerading as a vocal fold papilloma. Ear Nose Throat J. 86(10):594, 2007
- Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
- Barthel SW et al: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124(1):35-9, 2001
