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Glottic Laryngeal Squamous Cell Carcinoma
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Glottic squamous cell carcinoma (G-SCCa)
            • Definitions

              • SCCa arising on mucosal surface of glottic larynx
                • Vocal cord, anterior and posterior commissures

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        • Ultrasonographic Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Brady JS et al: Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. ePub, 2016
                                                  2. Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. ePub, 2016
                                                  3. Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
                                                  4. Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
                                                  5. Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. ePub, 2015
                                                  6. Tibbetts KM et al: Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
                                                  7. Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
                                                  8. Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
                                                  9. Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
                                                  10. Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
                                                  11. Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
                                                  12. Ansarin M et al: Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg. 135(4):385-90, 2009
                                                  13. Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
                                                  14. Hafidh M et al: Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg. 38(4):434-9, 2009
                                                  15. Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
                                                  16. Kuribayashi S et al: Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma. J Ultrasound Med. 28(11):1429-40, 2009
                                                  17. Patel NP et al: Metastatic calcification involving the true vocal cord. Am J Otolaryngol. 30(3):216-8, 2009
                                                  18. Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
                                                  19. Rödel RM et al: Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck. 31(5):583-92, 2009
                                                  20. Sachse F et al: Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck. 31(4):531-7, 2009
                                                  21. Shvero J et al: T1 glottic carcinoma involving the posterior commissure. Laryngoscope. 119(6):1116-9, 2009
                                                  22. Sjögren EV et al: Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 266(5):735-44, 2009
                                                  23. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                  24. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                  25. Charbonneau N et al: Treatment results of carcinoma in situ of the glottic larynx: 61 patients treated with radiotherapy. J Otolaryngol Head Neck Surg. 37(4):572-6, 2008
                                                  26. Choong NW et al: Recurrent laryngeal nerve palsy on integrated positron emission tomography-computed tomography. J Thorac Oncol. 3(10):1172, 2008
                                                  27. Dornfeld K et al: Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys. 71(2):386-92, 2008
                                                  28. Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
                                                  29. Kourelis K et al: Glottic versus supraglottic tumors: differential molecular profile. Eur Arch Otorhinolaryngol. 265(1):79-84, 2008
                                                  30. Nomiya T et al: Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope. 118(8):1417-21, 2008
                                                  31. Roh JL et al: The utility of second-look operation after laser microresection of glottic carcinoma involving the anterior commissure. Laryngoscope. 118(8):1400-4, 2008
                                                  32. Liu JC et al: Squamous cell carcinoma masquerading as a vocal fold papilloma. Ear Nose Throat J. 86(10):594, 2007
                                                  33. Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
                                                  34. Barthel SW et al: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124(1):35-9, 2001
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Glottic squamous cell carcinoma (G-SCCa)
                                                            • Definitions

                                                              • SCCa arising on mucosal surface of glottic larynx
                                                                • Vocal cord, anterior and posterior commissures

                                                            IMAGING

                                                            • General Features

                                                              • Radiographic Findings

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        • Ultrasonographic Findings

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Brady JS et al: Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. ePub, 2016
                                                                                                  2. Monnier Y et al: Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer. Head Neck. ePub, 2016
                                                                                                  3. Wang CC et al: Transoral robotic surgery for early glottic carcinoma involving anterior commissure: preliminary reports. Head Neck. 38(6):913-8, 2016
                                                                                                  4. Dziegielewski PT et al: Transoral robotic surgery (TORS) for laryngeal and hypopharyngeal cancers. J Surg Oncol. 112(7):702-6, 2015
                                                                                                  5. Hoffmann C et al: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope. ePub, 2015
                                                                                                  6. Tibbetts KM et al: Role of Advanced Laryngeal Imaging in Glottic Cancer: Early Detection and Evaluation of Glottic Neoplasms. Otolaryngol Clin North Am. 48(4):565-84, 2015
                                                                                                  7. Huang BY et al: Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am. 45(6):1325-61, 2012
                                                                                                  8. Chen SA et al: Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. Cancer. 117(22):5047-51, 2011
                                                                                                  9. Lim JY et al: Potential pitfalls and therapeutic implications of pretherapeutic radiologic staging in glottic cancers. Acta Otolaryngol. 131(8):869-75, 2011
                                                                                                  10. Beitler JJ et al: Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol. 28(14):2318-22, 2010
                                                                                                  11. Sengupta N et al: Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol. 33(1):94-5, 2010
                                                                                                  12. Ansarin M et al: Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg. 135(4):385-90, 2009
                                                                                                  13. Cagli S et al: The value of routine clinical and radiologic studies in predicting neoplastic invasion of cricoarytenoid units. AJNR Am J Neuroradiol. 30(10):1936-40, 2009
                                                                                                  14. Hafidh M et al: Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg. 38(4):434-9, 2009
                                                                                                  15. Karatzanis AD et al: Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope. 119(9):1704-8, 2009
                                                                                                  16. Kuribayashi S et al: Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma. J Ultrasound Med. 28(11):1429-40, 2009
                                                                                                  17. Patel NP et al: Metastatic calcification involving the true vocal cord. Am J Otolaryngol. 30(3):216-8, 2009
                                                                                                  18. Pittore B et al: Thyroarytenoid muscle invasion in T1 glottic carcinoma. Eur Arch Otorhinolaryngol. 266(11):1787-91, 2009
                                                                                                  19. Rödel RM et al: Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck. 31(5):583-92, 2009
                                                                                                  20. Sachse F et al: Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck. 31(4):531-7, 2009
                                                                                                  21. Shvero J et al: T1 glottic carcinoma involving the posterior commissure. Laryngoscope. 119(6):1116-9, 2009
                                                                                                  22. Sjögren EV et al: Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 266(5):735-44, 2009
                                                                                                  23. Becker M et al: Imaging of the larynx and hypopharynx. Eur J Radiol. 66(3):460-79, 2008
                                                                                                  24. Becker M et al: Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology. 249(2):551-9, 2008
                                                                                                  25. Charbonneau N et al: Treatment results of carcinoma in situ of the glottic larynx: 61 patients treated with radiotherapy. J Otolaryngol Head Neck Surg. 37(4):572-6, 2008
                                                                                                  26. Choong NW et al: Recurrent laryngeal nerve palsy on integrated positron emission tomography-computed tomography. J Thorac Oncol. 3(10):1172, 2008
                                                                                                  27. Dornfeld K et al: Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys. 71(2):386-92, 2008
                                                                                                  28. Hamzany Y et al: Laryngeal carcinoma in nonsmoking patients. Ann Otol Rhinol Laryngol. 117(8):564-8, 2008
                                                                                                  29. Kourelis K et al: Glottic versus supraglottic tumors: differential molecular profile. Eur Arch Otorhinolaryngol. 265(1):79-84, 2008
                                                                                                  30. Nomiya T et al: Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope. 118(8):1417-21, 2008
                                                                                                  31. Roh JL et al: The utility of second-look operation after laser microresection of glottic carcinoma involving the anterior commissure. Laryngoscope. 118(8):1400-4, 2008
                                                                                                  32. Liu JC et al: Squamous cell carcinoma masquerading as a vocal fold papilloma. Ear Nose Throat J. 86(10):594, 2007
                                                                                                  33. Hermans R: Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur Radiol. 16(11):2386-400, 2006
                                                                                                  34. Barthel SW et al: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124(1):35-9, 2001