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Goodpasture Syndrome
Aletta Ann Frazier, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Anti-glomerular basement membrane (anti-GBM) disease
              • Goodpasture disease
            • Definitions

              • Goodpasture syndrome: Coexistent glomerulonephritis and diffuse alveolar hemorrhage (DAH)
                • Antibodies directed against glomerular basement membranes; cross reaction with alveolar basement membranes
                • Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis, and DAH
              • Pulmonary-renal syndromes: Acute glomerulonephritis and alveolar capillaritis (DAH)
                • Anti-GBM disease, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), systemic lupus erythematosus (SLE)
              • Rare autoimmune disorder requiring immediate diagnosis and treatment to improve clinical outcome

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Reisman S et al: A review of clinical and imaging features of diffuse pulmonary hemorrhage. AJR Am J Roentgenol. 1-10, 2021
                                        2. Pesce F et al: Glomerulonephritis in AKI: from pathogenesis to therapeutic intervention. Front Med (Lausanne). 7:582272, 2020
                                        3. Boardman EA et al: Goodpasture's disease with late presentation of renal abnormality and anti-GBM autoantibody. BMJ Case Rep. 2017, 2017
                                        4. McAdoo SP et al: Anti-glomerular basement membrane disease. Clin J Am Soc Nephrol. 12(7):1162-72, 2017
                                        5. Fernandes R et al: Goodpasture's syndrome with absence of circulating anti-glomerular basement membrane antibodies: a case report. J Med Case Rep. 10:205, 2016
                                        6. Hellmark T et al: Diagnosis and classification of Goodpasture's disease (anti-GBM). J Autoimmun. 48-49:108-12, 2014
                                        7. Lichtenberger JP 3rd et al: Diffuse pulmonary hemorrhage: clues to the diagnosis. Curr Probl Diagn Radiol. 43(3):128-39, 2014
                                        8. Dammacco F et al: Goodpasture's disease: a report of ten cases and a review of the literature. Autoimmun Rev. 12(11):1101-8, 2013
                                        9. Hasleton et al: Pulmonary vasculitis and pulmonary hemorrhage syndromes. In Spencer's Pathology of the Lung. 6th ed. Cambridge University Press. 711-66, 2013
                                        10. Lahmer T et al: Anti-glomerular basement membrane antibody disease: a rare autoimmune disorder affecting the kidney and the lung. Autoimmun Rev. 12(2):169-73, 2012
                                        11. Chan AL et al: Cutting edge issues in Goodpasture's disease. Clin Rev Allergy Immunol. 41(2):151-62, 2011
                                        12. Pedchenko V et al: Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis. Curr Opin Nephrol Hypertens. 20(3):290-6, 2011
                                        13. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                        14. Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
                                        15. Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
                                        16. Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
                                        17. Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
                                        18. Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
                                        19. Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
                                        20. Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
                                        21. Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
                                        22. Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
                                        23. Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
                                        24. Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989
                                        25. Donaghy M et al: Cigarette smoking and lung haemorrhage in glomerulonephritis caused by autoantibodies to glomerular basement membrane. Lancet. 2(8364):1390-3, 1983
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Anti-glomerular basement membrane (anti-GBM) disease
                                                    • Goodpasture disease
                                                  • Definitions

                                                    • Goodpasture syndrome: Coexistent glomerulonephritis and diffuse alveolar hemorrhage (DAH)
                                                      • Antibodies directed against glomerular basement membranes; cross reaction with alveolar basement membranes
                                                      • Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis, and DAH
                                                    • Pulmonary-renal syndromes: Acute glomerulonephritis and alveolar capillaritis (DAH)
                                                      • Anti-GBM disease, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), systemic lupus erythematosus (SLE)
                                                    • Rare autoimmune disorder requiring immediate diagnosis and treatment to improve clinical outcome

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Reisman S et al: A review of clinical and imaging features of diffuse pulmonary hemorrhage. AJR Am J Roentgenol. 1-10, 2021
                                                                              2. Pesce F et al: Glomerulonephritis in AKI: from pathogenesis to therapeutic intervention. Front Med (Lausanne). 7:582272, 2020
                                                                              3. Boardman EA et al: Goodpasture's disease with late presentation of renal abnormality and anti-GBM autoantibody. BMJ Case Rep. 2017, 2017
                                                                              4. McAdoo SP et al: Anti-glomerular basement membrane disease. Clin J Am Soc Nephrol. 12(7):1162-72, 2017
                                                                              5. Fernandes R et al: Goodpasture's syndrome with absence of circulating anti-glomerular basement membrane antibodies: a case report. J Med Case Rep. 10:205, 2016
                                                                              6. Hellmark T et al: Diagnosis and classification of Goodpasture's disease (anti-GBM). J Autoimmun. 48-49:108-12, 2014
                                                                              7. Lichtenberger JP 3rd et al: Diffuse pulmonary hemorrhage: clues to the diagnosis. Curr Probl Diagn Radiol. 43(3):128-39, 2014
                                                                              8. Dammacco F et al: Goodpasture's disease: a report of ten cases and a review of the literature. Autoimmun Rev. 12(11):1101-8, 2013
                                                                              9. Hasleton et al: Pulmonary vasculitis and pulmonary hemorrhage syndromes. In Spencer's Pathology of the Lung. 6th ed. Cambridge University Press. 711-66, 2013
                                                                              10. Lahmer T et al: Anti-glomerular basement membrane antibody disease: a rare autoimmune disorder affecting the kidney and the lung. Autoimmun Rev. 12(2):169-73, 2012
                                                                              11. Chan AL et al: Cutting edge issues in Goodpasture's disease. Clin Rev Allergy Immunol. 41(2):151-62, 2011
                                                                              12. Pedchenko V et al: Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis. Curr Opin Nephrol Hypertens. 20(3):290-6, 2011
                                                                              13. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                                                              14. Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
                                                                              15. Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
                                                                              16. Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
                                                                              17. Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
                                                                              18. Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
                                                                              19. Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
                                                                              20. Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
                                                                              21. Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
                                                                              22. Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
                                                                              23. Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
                                                                              24. Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989
                                                                              25. Donaghy M et al: Cigarette smoking and lung haemorrhage in glomerulonephritis caused by autoantibodies to glomerular basement membrane. Lancet. 2(8364):1390-3, 1983