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Chest
Diagnosis
Connective Tissue Disorders, Immunological Diseases, and Vasculitis
Pulmonary Edema, Hemorrhage, and Vasculitis
Goodpasture Syndrome
Goodpasture Syndrome
John P. Lichtenberger, III, MD
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Anti-glomerular basement membrane (
a
n
ti-GBM) disease
Definitions
Goodpasture syndrome
: Described initially as combination glomerulonephritis & diffuse alveolar hemorrhage (DAH)
Caused by antibodies directed against glomerular basement membranes, cross-react with alveolar basement membranes
Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis & DAH
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Anti-glomerular basement membrane (
a
n
ti-GBM) disease
Definitions
Goodpasture syndrome
: Described initially as combination glomerulonephritis & diffuse alveolar hemorrhage (DAH)
Caused by antibodies directed against glomerular basement membranes, cross-react with alveolar basement membranes
Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis & DAH
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989
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