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Goodpasture Syndrome
John P. Lichtenberger, III, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Anti-glomerular basement membrane (anti-GBM) disease
            • Definitions

              • Goodpasture syndrome: Described initially as combination glomerulonephritis & diffuse alveolar hemorrhage (DAH)
                • Caused by antibodies directed against glomerular basement membranes, cross-react with alveolar basement membranes
                • Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis & DAH

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                        2. Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
                                        3. Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
                                        4. Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
                                        5. Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
                                        6. Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
                                        7. Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
                                        8. Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
                                        9. Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
                                        10. Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
                                        11. Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
                                        12. Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Anti-glomerular basement membrane (anti-GBM) disease
                                                  • Definitions

                                                    • Goodpasture syndrome: Described initially as combination glomerulonephritis & diffuse alveolar hemorrhage (DAH)
                                                      • Caused by antibodies directed against glomerular basement membranes, cross-react with alveolar basement membranes
                                                      • Anti-GBM disease: Circulating antiglomerular basement membrane antibodies, glomerulonephritis & DAH

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                                                              2. Lara AR et al: Diffuse alveolar hemorrhage. Chest. 137(5):1164-71, 2010
                                                                              3. Collard HR et al: Diffuse alveolar hemorrhage. Clin Chest Med. 25(3):583-92, vii, 2004
                                                                              4. Jara LJ et al: Pulmonary-renal vasculitic disorders: differential diagnosis and management. Curr Rheumatol Rep. 5(2):107-15, 2003
                                                                              5. Travis WD et al: Non-neoplastic disorders of the lower respiratory tract. AFIP Atlas of Nontumor Pathology, 1st ed. Washington, D.C.: 184-5, 2002
                                                                              6. Specks U: Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 13(1):12-7, 2001
                                                                              7. Savage CO et al: ABC of arterial and vascular disease: vasculitis. Bmj. 320(7245):1325-8, 2000
                                                                              8. Primack S: Pulmonary hemorrhage. In Chiles C et al: Pulmonary and cardiac Imaging. New York: Marcel Dekker. 219-43, 1997
                                                                              9. Primack SL et al: Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am J Roentgenol. 164(2):295-300, 1995
                                                                              10. Conlon PJ et al: Antiglomerular basement membrane disease: the long-term pulmonary outcome. Am J Kidney Dis. 23(6):794-6, 1994
                                                                              11. Muller NL et al: Diffuse pulmonary hemorrhage. Radiol Clin North Am. 29(5):965-71, 1991
                                                                              12. Young KR et al: Pulmonary-renal syndromes. Clin Chest Med. 10(4):655-75, 1989