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Granular Cell Tumor
Nicole S. Winkler, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Granular cell tumor (GCT)
              • Granular cell myoblastoma (GCM)
            • Definitions

              • Mesenchymal neoplasm composed of cells containing abundant eosinophilic granular cytoplasm derived from peripheral nerve Schwann cells

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Corso G et al: Granular cell tumor of the breast: molecular pathology and clinical management. Breast J. 24(5):778-82, 2018
                                          2. Torous VF et al: Benign breast lesions that mimic malignancy. Pathology. 49(2):181-196, 2017
                                          3. Terada T: Benign Granular cell tumor of breast. Breast J. 22(4):470-1, 2016
                                          4. Akahane K et al: Malignant granular cell tumor of the breast: case report and literature review. Breast Cancer. 22(3):317-23, 2015
                                          5. Gupta N et al: Malignant granular cell tumor of the breast; literature review. Indian J Pathol Microbiol. 58(2):238-40, 2015
                                          6. Rexeena B et al: Granular cell tumor of breast: a case report and review of literature. Indian J Surg Oncol. 6(4):446-8, 2015
                                          7. Ssi-Yan-Kai G et al: Granular cell breast cancer: a rare misleading lesion. Diagn Interv Imaging. 96(3):287-9, 2015
                                          8. Eusebi V et al. Tumours of the nipple. In: Lakhani SR et al. WHO Classification of Tumours of the Breast. 4th Edition Lyon, France: IARC; 2012
                                          9. Patel HB et al: Granular cell tumor in a male breast: Mammographic, sonographic, and pathologic features. J Clin Ultrasound. 2012 Jun 22. doi: 10. 1002/jcu. Epub ahead of print, 2196
                                          10. Park JY et al: Granular cell tumor occurring in the chest wall: a case report. Korean J Thorac Cardiovasc Surg. 45(3):196-8, 2012
                                          11. Kim EY et al: Granular cell tumor of the male breast: two case descriptions and brief review of the literature. J Ultrasound Med. 30(9):1295-301, 2011
                                          12. Lee SJ et al: The protean manifestations of granular cell tumor of the breast. Breast J. 17(2):201-3, 2011
                                          13. Lindskog DM et al: False-positive positron emission tomography in patients with history of malignancy. J Clin Oncol. 29(19):e582-5, 2011
                                          14. Mátrai Z et al: Granular cell tumour of the breast: case series and review of the literature. Eur J Gynaecol Oncol. 31(6):636-40, 2010
                                          15. Chung EM et al: From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation. Radiographics. 29(3):907-31, 2009
                                          16. Maki DD et al: Magnetic resonance appearance of granular cell tumor of the breast. Clin Imaging. 33(5):395-7, 2009
                                          17. Irshad A et al: Characterization of sonographic and mammographic features of granular cell tumors of the breast and estimation of their incidence. J Ultrasound Med. 27(3):467-75, 2008
                                          18. Scaranelo AM et al: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol. 80(960):970-4, 2007
                                          19. Porter GJ et al: Unusual benign breast lesions. Clin Radiol. 61(7):562-9, 2006
                                          20. Yang WT et al: Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound. 34(4):153-60, 2006
                                          21. Capobianco G et al: Granular cell tumor of the breast. Breast J. 11(6):519-20, 2005
                                          22. Adeniran A et al: Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J. 10(6):528-31, 2004
                                          23. Page DL et al: Diagnostic Histopathology of the Breast. UK: Longman Group. 312-3, 1987
                                          24. Patel A et al: Granular cell tumour of the pectoral muscle mimicking breast cancer. Cases J. 2008 Sep 6;1(1):142. doi: 10. PubMed Central PMCID: PMC2538504, 1186
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Granular cell tumor (GCT)
                                                      • Granular cell myoblastoma (GCM)
                                                    • Definitions

                                                      • Mesenchymal neoplasm composed of cells containing abundant eosinophilic granular cytoplasm derived from peripheral nerve Schwann cells

                                                    IMAGING

                                                    • General Features

                                                      • Mammographic Findings

                                                        • Ultrasonographic Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Corso G et al: Granular cell tumor of the breast: molecular pathology and clinical management. Breast J. 24(5):778-82, 2018
                                                                                  2. Torous VF et al: Benign breast lesions that mimic malignancy. Pathology. 49(2):181-196, 2017
                                                                                  3. Terada T: Benign Granular cell tumor of breast. Breast J. 22(4):470-1, 2016
                                                                                  4. Akahane K et al: Malignant granular cell tumor of the breast: case report and literature review. Breast Cancer. 22(3):317-23, 2015
                                                                                  5. Gupta N et al: Malignant granular cell tumor of the breast; literature review. Indian J Pathol Microbiol. 58(2):238-40, 2015
                                                                                  6. Rexeena B et al: Granular cell tumor of breast: a case report and review of literature. Indian J Surg Oncol. 6(4):446-8, 2015
                                                                                  7. Ssi-Yan-Kai G et al: Granular cell breast cancer: a rare misleading lesion. Diagn Interv Imaging. 96(3):287-9, 2015
                                                                                  8. Eusebi V et al. Tumours of the nipple. In: Lakhani SR et al. WHO Classification of Tumours of the Breast. 4th Edition Lyon, France: IARC; 2012
                                                                                  9. Patel HB et al: Granular cell tumor in a male breast: Mammographic, sonographic, and pathologic features. J Clin Ultrasound. 2012 Jun 22. doi: 10. 1002/jcu. Epub ahead of print, 2196
                                                                                  10. Park JY et al: Granular cell tumor occurring in the chest wall: a case report. Korean J Thorac Cardiovasc Surg. 45(3):196-8, 2012
                                                                                  11. Kim EY et al: Granular cell tumor of the male breast: two case descriptions and brief review of the literature. J Ultrasound Med. 30(9):1295-301, 2011
                                                                                  12. Lee SJ et al: The protean manifestations of granular cell tumor of the breast. Breast J. 17(2):201-3, 2011
                                                                                  13. Lindskog DM et al: False-positive positron emission tomography in patients with history of malignancy. J Clin Oncol. 29(19):e582-5, 2011
                                                                                  14. Mátrai Z et al: Granular cell tumour of the breast: case series and review of the literature. Eur J Gynaecol Oncol. 31(6):636-40, 2010
                                                                                  15. Chung EM et al: From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation. Radiographics. 29(3):907-31, 2009
                                                                                  16. Maki DD et al: Magnetic resonance appearance of granular cell tumor of the breast. Clin Imaging. 33(5):395-7, 2009
                                                                                  17. Irshad A et al: Characterization of sonographic and mammographic features of granular cell tumors of the breast and estimation of their incidence. J Ultrasound Med. 27(3):467-75, 2008
                                                                                  18. Scaranelo AM et al: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol. 80(960):970-4, 2007
                                                                                  19. Porter GJ et al: Unusual benign breast lesions. Clin Radiol. 61(7):562-9, 2006
                                                                                  20. Yang WT et al: Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound. 34(4):153-60, 2006
                                                                                  21. Capobianco G et al: Granular cell tumor of the breast. Breast J. 11(6):519-20, 2005
                                                                                  22. Adeniran A et al: Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J. 10(6):528-31, 2004
                                                                                  23. Page DL et al: Diagnostic Histopathology of the Breast. UK: Longman Group. 312-3, 1987
                                                                                  24. Patel A et al: Granular cell tumour of the pectoral muscle mimicking breast cancer. Cases J. 2008 Sep 6;1(1):142. doi: 10. PubMed Central PMCID: PMC2538504, 1186