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Granulomatosis With Polyangiitis (GPA)
Kyung Soo Lee, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Granulomatosis with polyangiitis (GPA)
          • Synonyms

            • Wegener granulomatosis (term no longer used)
          • Definitions

            • Multisystem necrotizing granulomatous vasculitis of autoimmune origin, which affects small to medium-sized vessels

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • Nuclear Medicine Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Feragalli B et al: The lung in systemic vasculitis: radiological patterns and differential diagnosis. Br J Radiol. 89(1061):20150992, 2016
                                    2. Serra G et al: Thoracic involvement in systemic primary vasculitis: radiological patterns and follow-up. JBR-BTR. 97(2):57-68, 2014
                                    3. CastaƱer E et al: Imaging findings in pulmonary vasculitis. Semin Ultrasound CT MR. 33(6):567-79, 2012
                                    4. Martinez F et al: Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 32(1):51-69, 2012
                                    5. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                    6. Ananthakrishnan L et al: Wegener's granulomatosis in the chest: high-resolution CT findings. AJR Am J Roentgenol. 192(3):676-82, 2009
                                    7. Allen SD et al: Imaging of Wegener's granulomatosis. Br J Radiol. 80(957):757-65, 2007
                                    8. Lee KS et al: Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients. Eur Radiol. 13(1):43-51, 2003
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Granulomatosis with polyangiitis (GPA)
                                            • Synonyms

                                              • Wegener granulomatosis (term no longer used)
                                            • Definitions

                                              • Multisystem necrotizing granulomatous vasculitis of autoimmune origin, which affects small to medium-sized vessels

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • Nuclear Medicine Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Feragalli B et al: The lung in systemic vasculitis: radiological patterns and differential diagnosis. Br J Radiol. 89(1061):20150992, 2016
                                                                      2. Serra G et al: Thoracic involvement in systemic primary vasculitis: radiological patterns and follow-up. JBR-BTR. 97(2):57-68, 2014
                                                                      3. CastaƱer E et al: Imaging findings in pulmonary vasculitis. Semin Ultrasound CT MR. 33(6):567-79, 2012
                                                                      4. Martinez F et al: Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 32(1):51-69, 2012
                                                                      5. Chung MP et al: Imaging of pulmonary vasculitis. Radiology. 255(2):322-41, 2010
                                                                      6. Ananthakrishnan L et al: Wegener's granulomatosis in the chest: high-resolution CT findings. AJR Am J Roentgenol. 192(3):676-82, 2009
                                                                      7. Allen SD et al: Imaging of Wegener's granulomatosis. Br J Radiol. 80(957):757-65, 2007
                                                                      8. Lee KS et al: Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients. Eur Radiol. 13(1):43-51, 2003