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Granulosa Cell Tumor
Akram M. Shaaban, MBBCh
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Granulosa cell tumor (GCT)
            • Definitions

              • GCT classified as sex cord tumor with 2 subtypes
                • Adult GCT
                  • Tumor composed of granulosa cells growing in variety of patterns, admixed with variable population of fibroblasts or theca cells
                  • ~ 95% of all GCTs
                • Juvenile GCT
                  • Tumor composed of primitive-appearing granulosa cells growing in solid and follicular patterns
                  • ~ 5% of all GCTs

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • PET/CT

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Taylor EC et al: Multimodality imaging approach to ovarian neoplasms with pathologic correlation. Radiographics. 41(1):280-315, 2021
                                        2. Kilinc Y et al: Ovarian granulosa cell tumor: a clinicoradiologic series with literature review. Curr Med Imaging. ePub, 2020
                                        3. Stine JE et al: Pre-operative imaging with CA125 is a poor predictor for granulosa cell tumors. Gynecol Oncol. 131(1):59-62, 2013
                                        4. Chung EM et al: From the radiologic pathology archives: precocious puberty: radiologic-pathologic correlation. Radiographics. 32(7):2071-99, 2012
                                        5. Wang Y et al: Childhood ovarian juvenile granulosa cell tumor: a retrospective study with 3 cases including clinical features, pathologic results, and therapies. J Pediatr Hematol Oncol. 33(3):241-5, 2011
                                        6. Kim JA et al: High-resolution sonographic findings of ovarian granulosa cell tumors: correlation with pathologic findings. J Ultrasound Med. 29(2):187-93, 2010
                                        7. Raj G et al: Positron emission tomography and granulosa cell tumor recurrence: a report of 2 cases. Int J Gynecol Cancer. 19(9):1542-4, 2009
                                        8. Van Holsbeke C et al: Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary. Ultrasound Obstet Gynecol. 31(4):450-6, 2008
                                        9. Crew KD et al: Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 96(1):235-40, 2005
                                        10. Jung SE et al: CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 185(1):207-15, 2005
                                        11. Tanaka YO et al: Functioning ovarian tumors: direct and indirect findings at MR imaging. Radiographics. 24 Suppl 1:S147-66, 2004
                                        12. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Granulosa cell tumor (GCT)
                                                  • Definitions

                                                    • GCT classified as sex cord tumor with 2 subtypes
                                                      • Adult GCT
                                                        • Tumor composed of granulosa cells growing in variety of patterns, admixed with variable population of fibroblasts or theca cells
                                                        • ~ 95% of all GCTs
                                                      • Juvenile GCT
                                                        • Tumor composed of primitive-appearing granulosa cells growing in solid and follicular patterns
                                                        • ~ 5% of all GCTs

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • PET/CT

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Taylor EC et al: Multimodality imaging approach to ovarian neoplasms with pathologic correlation. Radiographics. 41(1):280-315, 2021
                                                                              2. Kilinc Y et al: Ovarian granulosa cell tumor: a clinicoradiologic series with literature review. Curr Med Imaging. ePub, 2020
                                                                              3. Stine JE et al: Pre-operative imaging with CA125 is a poor predictor for granulosa cell tumors. Gynecol Oncol. 131(1):59-62, 2013
                                                                              4. Chung EM et al: From the radiologic pathology archives: precocious puberty: radiologic-pathologic correlation. Radiographics. 32(7):2071-99, 2012
                                                                              5. Wang Y et al: Childhood ovarian juvenile granulosa cell tumor: a retrospective study with 3 cases including clinical features, pathologic results, and therapies. J Pediatr Hematol Oncol. 33(3):241-5, 2011
                                                                              6. Kim JA et al: High-resolution sonographic findings of ovarian granulosa cell tumors: correlation with pathologic findings. J Ultrasound Med. 29(2):187-93, 2010
                                                                              7. Raj G et al: Positron emission tomography and granulosa cell tumor recurrence: a report of 2 cases. Int J Gynecol Cancer. 19(9):1542-4, 2009
                                                                              8. Van Holsbeke C et al: Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary. Ultrasound Obstet Gynecol. 31(4):450-6, 2008
                                                                              9. Crew KD et al: Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 96(1):235-40, 2005
                                                                              10. Jung SE et al: CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 185(1):207-15, 2005
                                                                              11. Tanaka YO et al: Functioning ovarian tumors: direct and indirect findings at MR imaging. Radiographics. 24 Suppl 1:S147-66, 2004
                                                                              12. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002