Hilda Tso, DO; Wendie A. Berg, MD, PhD, FACR, FSBI
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Mammary hamartoma (MH), fibroadenolipoma (FAL)
Synonyms
Hamartoma, lipofibroadenoma, adenolipofibroma (named according to relative amount of tissue component in mass)
Definitions
Discrete fat and fibroglandular proliferation
Focal developmental pseudotumor composed of fibrous, glandular, and fatty tissue
Myoid hamartoma: Misnomer, as not hamartoma per se; biphasic benign nodule with adenosis and smooth muscle metaplasia of stroma; rarely contains fat
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Eng C et al: PTEN hamartoma tumor syndrome. In Adam MP et al. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018
Baer L et al: The first case of HER2+ invasive ductal carcinoma arising from a breast hamartoma and literature review. J Natl Med Assoc. 109(1):55-59, 2017
Amir RA et al: Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity. Int J Surg Case Rep. 22:1-4, 2016
Bhatia M et al: "Breast within a breast" sign: Mammary hamartoma. Med J Armed Forces India. 71(4):377-9, 2015
Presazzi A et al: Breast hamartoma: ultrasound, elastosonographic, and mammographic features. Mini pictorial essay. J Ultrasound. 18(4):373-7, 2015
Ayyappan AP et al: Imaging of fat-containing lesions of the breast: a pictorial essay. J Clin Ultrasound. 41(7):424-33, 2013
Tan MH et al: Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res. 18(2):400-7, 2012
Erdem G et al: Advanced MRI findings in patients with breast hamartomas. Diagn Interv Radiol. 17(1):33-7, 2011
Desai A et al: Breast hamartoma arising in axillary ectopic breast tissue. Breast J. 16(4):433-4, 2010
Chang HL et al: Breast hamartomas in adolescent females. Breast J. 15(5):515-20, 2009
Box I et al: Large mammographic opacity due to hamartoma. JBR-BTR. 91(4):177, 2008
Park YM et al: Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? Acta Radiol. 49(10):1104-11, 2008
Chao TC et al: Sonographic features of breast hamartomas. J Ultrasound Med. 26(4):447-52; quiz 453, 2007
Murat A et al: Hamartoma of the breast. Australas Radiol. 51 Spec No, 2007
da Silva BB et al: Large mammary hamartoma of axillary supernumerary breast tissue. Breast. 15(1):135-6, 2006
Lerwill MF: Biphasic lesions of the breast. Semin Diagn Pathol. 21(1):48-56, 2004
Baron M et al: Invasive lobular carcinoma in a breast hamartoma. Breast J. 9(3):246-8, 2003
Gomez-Aracil V et al: Fine needle aspiration cytology of mammary hamartoma: a review of nine cases with histological correlation. Cytopathology. 14(4):195-200, 2003
Lee EH et al: Invasive ductal carcinoma arising in a breast hamartoma: two case reports and a review of the literature. Clin Radiol. 58(1):80-3, 2003
Park SY et al: Sonographic findings of breast hamartoma: emphasis on compressibility. Yonsei Med J. 44(5):847-54, 2003
Herbert M et al: Breast hamartomas: clinicopathological and immunohistochemical studies of 24 cases. Histopathology. 41(1):30-4, 2002
Tse GM et al: Ductal carcinoma in situ arising in mammary hamartoma. J Clin Pathol. 55(7):541-2, 2002
Ravakhah K et al: Hamartoma of the breast in a man: first case report. Breast J. 7(4):266-8, 2001
Wahner-Roedler DL et al: Hamartomas of the breast: clinical, radiologic, and pathologic manifestations. Breast J. 7(2):101-5, 2001
Weinzweig N et al: Giant hamartoma of the breast. Plast Reconstr Surg. 107(5):1216-20, 2001
Chiacchio R et al: Mammary hamartomas: an immunohistochemical study of ten cases. Pathol Res Pract. 195(4):231-6, 1999
Khunamornpong S et al: Muscular hamartoma of the breast: a rare breast lesion containing smooth muscle. J Med Assoc Thai. 80(10):675-9, 1997
Dworak O et al: Hamartoma of an ectopic breast arising in the inguinal region. Histopathology. 24(2):169-71, 1994
Altermatt HJ et al: Multiple hamartomas of the breast. Appl Pathol. 7(2):145-8, 1989
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Mammary hamartoma (MH), fibroadenolipoma (FAL)
Synonyms
Hamartoma, lipofibroadenoma, adenolipofibroma (named according to relative amount of tissue component in mass)
Definitions
Discrete fat and fibroglandular proliferation
Focal developmental pseudotumor composed of fibrous, glandular, and fatty tissue
Myoid hamartoma: Misnomer, as not hamartoma per se; biphasic benign nodule with adenosis and smooth muscle metaplasia of stroma; rarely contains fat
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Eng C et al: PTEN hamartoma tumor syndrome. In Adam MP et al. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018
Baer L et al: The first case of HER2+ invasive ductal carcinoma arising from a breast hamartoma and literature review. J Natl Med Assoc. 109(1):55-59, 2017
Amir RA et al: Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity. Int J Surg Case Rep. 22:1-4, 2016
Bhatia M et al: "Breast within a breast" sign: Mammary hamartoma. Med J Armed Forces India. 71(4):377-9, 2015
Presazzi A et al: Breast hamartoma: ultrasound, elastosonographic, and mammographic features. Mini pictorial essay. J Ultrasound. 18(4):373-7, 2015
Ayyappan AP et al: Imaging of fat-containing lesions of the breast: a pictorial essay. J Clin Ultrasound. 41(7):424-33, 2013
Tan MH et al: Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res. 18(2):400-7, 2012
Erdem G et al: Advanced MRI findings in patients with breast hamartomas. Diagn Interv Radiol. 17(1):33-7, 2011
Desai A et al: Breast hamartoma arising in axillary ectopic breast tissue. Breast J. 16(4):433-4, 2010
Chang HL et al: Breast hamartomas in adolescent females. Breast J. 15(5):515-20, 2009
Box I et al: Large mammographic opacity due to hamartoma. JBR-BTR. 91(4):177, 2008
Park YM et al: Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? Acta Radiol. 49(10):1104-11, 2008
Chao TC et al: Sonographic features of breast hamartomas. J Ultrasound Med. 26(4):447-52; quiz 453, 2007
Murat A et al: Hamartoma of the breast. Australas Radiol. 51 Spec No, 2007
da Silva BB et al: Large mammary hamartoma of axillary supernumerary breast tissue. Breast. 15(1):135-6, 2006
Lerwill MF: Biphasic lesions of the breast. Semin Diagn Pathol. 21(1):48-56, 2004
Baron M et al: Invasive lobular carcinoma in a breast hamartoma. Breast J. 9(3):246-8, 2003
Gomez-Aracil V et al: Fine needle aspiration cytology of mammary hamartoma: a review of nine cases with histological correlation. Cytopathology. 14(4):195-200, 2003
Lee EH et al: Invasive ductal carcinoma arising in a breast hamartoma: two case reports and a review of the literature. Clin Radiol. 58(1):80-3, 2003
Park SY et al: Sonographic findings of breast hamartoma: emphasis on compressibility. Yonsei Med J. 44(5):847-54, 2003
Herbert M et al: Breast hamartomas: clinicopathological and immunohistochemical studies of 24 cases. Histopathology. 41(1):30-4, 2002
Tse GM et al: Ductal carcinoma in situ arising in mammary hamartoma. J Clin Pathol. 55(7):541-2, 2002
Ravakhah K et al: Hamartoma of the breast in a man: first case report. Breast J. 7(4):266-8, 2001
Wahner-Roedler DL et al: Hamartomas of the breast: clinical, radiologic, and pathologic manifestations. Breast J. 7(2):101-5, 2001
Weinzweig N et al: Giant hamartoma of the breast. Plast Reconstr Surg. 107(5):1216-20, 2001
Chiacchio R et al: Mammary hamartomas: an immunohistochemical study of ten cases. Pathol Res Pract. 195(4):231-6, 1999
Khunamornpong S et al: Muscular hamartoma of the breast: a rare breast lesion containing smooth muscle. J Med Assoc Thai. 80(10):675-9, 1997
Dworak O et al: Hamartoma of an ectopic breast arising in the inguinal region. Histopathology. 24(2):169-71, 1994
Altermatt HJ et al: Multiple hamartomas of the breast. Appl Pathol. 7(2):145-8, 1989
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