Pneumoconiosis resulting from inhalation of hard metal
Hard metals: Cobalt and cobalt alloys (e.g., tungsten)
Hypersensitivity reaction with histologic features of GIP
History of exposure to metal dust
Characteristic clinical features of shortness of breath, cough, and dyspnea on exertion over long period
Radiologic features of interstitial lung disease
↑ concentration of cobalt in lung tissue
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Khoor A et al: Giant cell interstitial pneumonia in patients without hard metal exposure: analysis of 3 cases and review of the literature. Hum Pathol. 50:176-82, 2016
Choi JW et al: Giant cell interstitial pneumonia: high-resolution CT and pathologic findings in four adult patients. AJR Am J Roentgenol. 184(1):268-72, 2005
Dunlop P et al: Hard metal lung disease: high resolution CT and histologic correlation of the initial findings and demonstration of interval improvement. J Thorac Imaging. 20(4):301-4, 2005
Gotway MB et al: Hard metal interstitial lung disease: high-resolution computed tomography appearance. J Thorac Imaging. 17(4):314-8, 2002
Akira M. Uncommon pneumoconiosis: CT and pathologic findings. Radiology 1995;197(2):403–409.
Posgay M et al: Radiological aspects of hard metal disease. Rofo. 159(5):439-43, 1993
Sprince NL et al: Cobalt exposure and lung disease in tungsten carbide production. A cross-sectional study of current workers. Am Rev Respir Dis. 138(5):1220-6, 1988
Coates EO Jr et al: Diffuse interstitial lung disease in tungsten carbide workers. Ann Intern Med. 75(5):709-16, 1971
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Giant cell interstitial pneumonia (GIP)
Definitions
Pneumoconiosis resulting from inhalation of hard metal
Hard metals: Cobalt and cobalt alloys (e.g., tungsten)
Hypersensitivity reaction with histologic features of GIP
History of exposure to metal dust
Characteristic clinical features of shortness of breath, cough, and dyspnea on exertion over long period
Radiologic features of interstitial lung disease
↑ concentration of cobalt in lung tissue
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Khoor A et al: Giant cell interstitial pneumonia in patients without hard metal exposure: analysis of 3 cases and review of the literature. Hum Pathol. 50:176-82, 2016
Choi JW et al: Giant cell interstitial pneumonia: high-resolution CT and pathologic findings in four adult patients. AJR Am J Roentgenol. 184(1):268-72, 2005
Dunlop P et al: Hard metal lung disease: high resolution CT and histologic correlation of the initial findings and demonstration of interval improvement. J Thorac Imaging. 20(4):301-4, 2005
Gotway MB et al: Hard metal interstitial lung disease: high-resolution computed tomography appearance. J Thorac Imaging. 17(4):314-8, 2002
Akira M. Uncommon pneumoconiosis: CT and pathologic findings. Radiology 1995;197(2):403–409.
Posgay M et al: Radiological aspects of hard metal disease. Rofo. 159(5):439-43, 1993
Sprince NL et al: Cobalt exposure and lung disease in tungsten carbide production. A cross-sectional study of current workers. Am Rev Respir Dis. 138(5):1220-6, 1988
Coates EO Jr et al: Diffuse interstitial lung disease in tungsten carbide workers. Ann Intern Med. 75(5):709-16, 1971
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