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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Hemangioblastoma (HGBL)
Synonyms
- Capillary hemangioma
Definitions
- Benign, slow-growing, highly vascular tumor of adults most commonly found in cerebellum, brainstem, spinal cord
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Gläsker S et al: Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther. 13:5669-90, 2020
- Klingler JH et al: Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment. Childs Nerv Syst. ePub, 2020
- Qiu J et al: Stereotactic radiosurgery for central nervous system hemangioblastoma in von Hippel-Lindau disease: a systematic review and meta-analysis. Clin Neurol Neurosurg. 195:105912, 2020
- Darbari S et al: Optic nerve hemangioblastoma: review. World Neurosurg. 128:211-5, 2019
- Schattner A et al: Cerebellar hemangioblastoma. Am J Med. 131(1):e15-16, 2018
- Bisceglia M et al: Extraneuraxial hemangioblastoma: clinicopathologic features and review of the literature. Adv Anat Pathol. 25(3):197-215, 2017
- Goo HW et al: Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging. J Neurosurg Pediatr. 1-4, 2015
- Kano H et al: Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study. J Neurosurg. 1-10, 2015
- Gorovoy IR et al: Retinal hemangioblastoma. JAMA Ophthalmol. 132(3):325, 2014
- Liao CC et al: Clinical features and surgical outcomes of sporadic cerebellar hemangioblastomas. Clin Neurol Neurosurg. 125:160-5, 2014
- Shin GW et al: Preoperative embolization of cerebellar hemangioblastoma with onyx: report of three cases. Neurointervention. 9(1):45-9, 2014
- Courcoutsakis NA et al: Aggressive leptomeningeal hemangioblastomatosis of the central nervous system in a patient with von Hippel-Lindau disease. AJNR Am J Neuroradiol. 30(4):758-60, 2009
- Parker F et al: Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: a comparison of two distinct clinical patient groups. J Neurooncol. 93(1):133-7, 2009
- Rachinger J et al: Solid haemangioblastomas of the CNS: a review of 17 consecutive cases. Neurosurg Rev. 32(1):37-47; discussion 47-8, 2009
- Ros de San Pedro J et al: Massive hemorrhage in hemangioblastoma: literature review. Neurosurg Rev. 33(1):11-26, 2009
- Shekhar H et al: Von Hippel-Lindau disease: delayed presentation as a cerebellar haemangioblastoma in an elderly patient. Br J Neurosurg. 23(1):97-8, 2009
- Barrett R et al: Optic nerve hemangioblastoma. Ophthalmology. 115(11):2095, 2008
- Jagannathan J et al: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg. 108(2):210-22, 2008
- Kano H et al: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery. 63(3):443-50; discussion 450-1, 2008
- Montano N et al: Embolization of hemangioblastomas. J Neurosurg. 108(5):1063-4; author reply 1064-5, 2008
- Takeuchi H et al: A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology. 28(1):98-102, 2008
- Innus C et al: Hemangioblastoma without von Hippel-Lindau disease. JAAPA. 20(11):28, 31-2, 2007
- Hoang MP et al: Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am J Surg Pathol. 27(8):1152-6, 2003
- Reyns N et al: Leptomeningeal hemangioblastomatosis in a case of von Hippel-Lindau disease: case report. Neurosurgery. 52(5):1212-5; discussion 1215-6, 2003
- Sarkar C et al: August 2002: 21-year-old male with cystic intracerebral tumor. Brain Pathol. 13(1):113-4, 117, 2003
- Wanebo JE et al: The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg. 98(1):82-94, 2003
- Weil RJ et al: Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. Report of four cases. J Neurosurg. 96(4):775-87, 2002
- Conway JE et al: Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 48(1):55-62; discussion 62-3, 2001
- Kondo T et al: Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas. J Neurosurg. 95(2):292-7, 2001
- Wang C et al: Surgical management of medullary hemangioblastoma. Report of 47 cases. Surg Neurol. 56(4):218-26; discussion 226-7, 2001
- Bohling T et al: von Hippel-Lindau disease and capillary hemangioblastoma. In Kleihues P et al: Tumours of the Nervous System. Lyon: IARC Press. 223-6, 2000
- Miyagami M et al: Clinicopathological study of vascular endothelial growth factor (VEGF), p53, and proliferative potential in familial von Hippel-Lindau disease and sporadic hemangioblastomas. Brain Tumor Pathol. 17(3):111-20, 2000
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Hemangioblastoma (HGBL)
Synonyms
- Capillary hemangioma
Definitions
- Benign, slow-growing, highly vascular tumor of adults most commonly found in cerebellum, brainstem, spinal cord
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Gläsker S et al: Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther. 13:5669-90, 2020
- Klingler JH et al: Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment. Childs Nerv Syst. ePub, 2020
- Qiu J et al: Stereotactic radiosurgery for central nervous system hemangioblastoma in von Hippel-Lindau disease: a systematic review and meta-analysis. Clin Neurol Neurosurg. 195:105912, 2020
- Darbari S et al: Optic nerve hemangioblastoma: review. World Neurosurg. 128:211-5, 2019
- Schattner A et al: Cerebellar hemangioblastoma. Am J Med. 131(1):e15-16, 2018
- Bisceglia M et al: Extraneuraxial hemangioblastoma: clinicopathologic features and review of the literature. Adv Anat Pathol. 25(3):197-215, 2017
- Goo HW et al: Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging. J Neurosurg Pediatr. 1-4, 2015
- Kano H et al: Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study. J Neurosurg. 1-10, 2015
- Gorovoy IR et al: Retinal hemangioblastoma. JAMA Ophthalmol. 132(3):325, 2014
- Liao CC et al: Clinical features and surgical outcomes of sporadic cerebellar hemangioblastomas. Clin Neurol Neurosurg. 125:160-5, 2014
- Shin GW et al: Preoperative embolization of cerebellar hemangioblastoma with onyx: report of three cases. Neurointervention. 9(1):45-9, 2014
- Courcoutsakis NA et al: Aggressive leptomeningeal hemangioblastomatosis of the central nervous system in a patient with von Hippel-Lindau disease. AJNR Am J Neuroradiol. 30(4):758-60, 2009
- Parker F et al: Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: a comparison of two distinct clinical patient groups. J Neurooncol. 93(1):133-7, 2009
- Rachinger J et al: Solid haemangioblastomas of the CNS: a review of 17 consecutive cases. Neurosurg Rev. 32(1):37-47; discussion 47-8, 2009
- Ros de San Pedro J et al: Massive hemorrhage in hemangioblastoma: literature review. Neurosurg Rev. 33(1):11-26, 2009
- Shekhar H et al: Von Hippel-Lindau disease: delayed presentation as a cerebellar haemangioblastoma in an elderly patient. Br J Neurosurg. 23(1):97-8, 2009
- Barrett R et al: Optic nerve hemangioblastoma. Ophthalmology. 115(11):2095, 2008
- Jagannathan J et al: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg. 108(2):210-22, 2008
- Kano H et al: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery. 63(3):443-50; discussion 450-1, 2008
- Montano N et al: Embolization of hemangioblastomas. J Neurosurg. 108(5):1063-4; author reply 1064-5, 2008
- Takeuchi H et al: A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology. 28(1):98-102, 2008
- Innus C et al: Hemangioblastoma without von Hippel-Lindau disease. JAAPA. 20(11):28, 31-2, 2007
- Hoang MP et al: Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am J Surg Pathol. 27(8):1152-6, 2003
- Reyns N et al: Leptomeningeal hemangioblastomatosis in a case of von Hippel-Lindau disease: case report. Neurosurgery. 52(5):1212-5; discussion 1215-6, 2003
- Sarkar C et al: August 2002: 21-year-old male with cystic intracerebral tumor. Brain Pathol. 13(1):113-4, 117, 2003
- Wanebo JE et al: The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg. 98(1):82-94, 2003
- Weil RJ et al: Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. Report of four cases. J Neurosurg. 96(4):775-87, 2002
- Conway JE et al: Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 48(1):55-62; discussion 62-3, 2001
- Kondo T et al: Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas. J Neurosurg. 95(2):292-7, 2001
- Wang C et al: Surgical management of medullary hemangioblastoma. Report of 47 cases. Surg Neurol. 56(4):218-26; discussion 226-7, 2001
- Bohling T et al: von Hippel-Lindau disease and capillary hemangioblastoma. In Kleihues P et al: Tumours of the Nervous System. Lyon: IARC Press. 223-6, 2000
- Miyagami M et al: Clinicopathological study of vascular endothelial growth factor (VEGF), p53, and proliferative potential in familial von Hippel-Lindau disease and sporadic hemangioblastomas. Brain Tumor Pathol. 17(3):111-20, 2000
