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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Hemangioblastoma (HGBL)
Synonyms
Capillary hemangioma
Definitions
Benign, slow-growing, highly vascular tumor of adults most commonly found in cerebellum, brainstem, spinal cord
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gläsker S et al: Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther. 13:5669-90, 2020
Klingler JH et al: Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment. Childs Nerv Syst. ePub, 2020
Qiu J et al: Stereotactic radiosurgery for central nervous system hemangioblastoma in von Hippel-Lindau disease: a systematic review and meta-analysis. Clin Neurol Neurosurg. 195:105912, 2020
Darbari S et al: Optic nerve hemangioblastoma: review. World Neurosurg. 128:211-5, 2019
Schattner A et al: Cerebellar hemangioblastoma. Am J Med. 131(1):e15-16, 2018
Bisceglia M et al: Extraneuraxial hemangioblastoma: clinicopathologic features and review of the literature. Adv Anat Pathol. 25(3):197-215, 2017
Goo HW et al: Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging. J Neurosurg Pediatr. 1-4, 2015
Kano H et al: Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study. J Neurosurg. 1-10, 2015
Gorovoy IR et al: Retinal hemangioblastoma. JAMA Ophthalmol. 132(3):325, 2014
Liao CC et al: Clinical features and surgical outcomes of sporadic cerebellar hemangioblastomas. Clin Neurol Neurosurg. 125:160-5, 2014
Shin GW et al: Preoperative embolization of cerebellar hemangioblastoma with onyx: report of three cases. Neurointervention. 9(1):45-9, 2014
Courcoutsakis NA et al: Aggressive leptomeningeal hemangioblastomatosis of the central nervous system in a patient with von Hippel-Lindau disease. AJNR Am J Neuroradiol. 30(4):758-60, 2009
Parker F et al: Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: a comparison of two distinct clinical patient groups. J Neurooncol. 93(1):133-7, 2009
Rachinger J et al: Solid haemangioblastomas of the CNS: a review of 17 consecutive cases. Neurosurg Rev. 32(1):37-47; discussion 47-8, 2009
Ros de San Pedro J et al: Massive hemorrhage in hemangioblastoma: literature review. Neurosurg Rev. 33(1):11-26, 2009
Shekhar H et al: Von Hippel-Lindau disease: delayed presentation as a cerebellar haemangioblastoma in an elderly patient. Br J Neurosurg. 23(1):97-8, 2009
Barrett R et al: Optic nerve hemangioblastoma. Ophthalmology. 115(11):2095, 2008
Jagannathan J et al: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg. 108(2):210-22, 2008
Kano H et al: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery. 63(3):443-50; discussion 450-1, 2008
Montano N et al: Embolization of hemangioblastomas. J Neurosurg. 108(5):1063-4; author reply 1064-5, 2008
Takeuchi H et al: A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology. 28(1):98-102, 2008
Innus C et al: Hemangioblastoma without von Hippel-Lindau disease. JAAPA. 20(11):28, 31-2, 2007
Hoang MP et al: Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am J Surg Pathol. 27(8):1152-6, 2003
Reyns N et al: Leptomeningeal hemangioblastomatosis in a case of von Hippel-Lindau disease: case report. Neurosurgery. 52(5):1212-5; discussion 1215-6, 2003
Sarkar C et al: August 2002: 21-year-old male with cystic intracerebral tumor. Brain Pathol. 13(1):113-4, 117, 2003
Wanebo JE et al: The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg. 98(1):82-94, 2003
Weil RJ et al: Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. Report of four cases. J Neurosurg. 96(4):775-87, 2002
Conway JE et al: Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 48(1):55-62; discussion 62-3, 2001
Kondo T et al: Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas. J Neurosurg. 95(2):292-7, 2001
Wang C et al: Surgical management of medullary hemangioblastoma. Report of 47 cases. Surg Neurol. 56(4):218-26; discussion 226-7, 2001
Bohling T et al: von Hippel-Lindau disease and capillary hemangioblastoma. In Kleihues P et al: Tumours of the Nervous System. Lyon: IARC Press. 223-6, 2000
Miyagami M et al: Clinicopathological study of vascular endothelial growth factor (VEGF), p53, and proliferative potential in familial von Hippel-Lindau disease and sporadic hemangioblastomas. Brain Tumor Pathol. 17(3):111-20, 2000
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Hemangioblastoma (HGBL)
Synonyms
Capillary hemangioma
Definitions
Benign, slow-growing, highly vascular tumor of adults most commonly found in cerebellum, brainstem, spinal cord
IMAGING
General Features
CT Findings
MR Findings
Angiographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gläsker S et al: Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther. 13:5669-90, 2020
Klingler JH et al: Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment. Childs Nerv Syst. ePub, 2020
Qiu J et al: Stereotactic radiosurgery for central nervous system hemangioblastoma in von Hippel-Lindau disease: a systematic review and meta-analysis. Clin Neurol Neurosurg. 195:105912, 2020
Darbari S et al: Optic nerve hemangioblastoma: review. World Neurosurg. 128:211-5, 2019
Schattner A et al: Cerebellar hemangioblastoma. Am J Med. 131(1):e15-16, 2018
Bisceglia M et al: Extraneuraxial hemangioblastoma: clinicopathologic features and review of the literature. Adv Anat Pathol. 25(3):197-215, 2017
Goo HW et al: Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging. J Neurosurg Pediatr. 1-4, 2015
Kano H et al: Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study. J Neurosurg. 1-10, 2015
Gorovoy IR et al: Retinal hemangioblastoma. JAMA Ophthalmol. 132(3):325, 2014
Liao CC et al: Clinical features and surgical outcomes of sporadic cerebellar hemangioblastomas. Clin Neurol Neurosurg. 125:160-5, 2014
Shin GW et al: Preoperative embolization of cerebellar hemangioblastoma with onyx: report of three cases. Neurointervention. 9(1):45-9, 2014
Courcoutsakis NA et al: Aggressive leptomeningeal hemangioblastomatosis of the central nervous system in a patient with von Hippel-Lindau disease. AJNR Am J Neuroradiol. 30(4):758-60, 2009
Parker F et al: Results of microsurgical treatment of medulla oblongata and spinal cord hemangioblastomas: a comparison of two distinct clinical patient groups. J Neurooncol. 93(1):133-7, 2009
Rachinger J et al: Solid haemangioblastomas of the CNS: a review of 17 consecutive cases. Neurosurg Rev. 32(1):37-47; discussion 47-8, 2009
Ros de San Pedro J et al: Massive hemorrhage in hemangioblastoma: literature review. Neurosurg Rev. 33(1):11-26, 2009
Shekhar H et al: Von Hippel-Lindau disease: delayed presentation as a cerebellar haemangioblastoma in an elderly patient. Br J Neurosurg. 23(1):97-8, 2009
Barrett R et al: Optic nerve hemangioblastoma. Ophthalmology. 115(11):2095, 2008
Jagannathan J et al: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg. 108(2):210-22, 2008
Kano H et al: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery. 63(3):443-50; discussion 450-1, 2008
Montano N et al: Embolization of hemangioblastomas. J Neurosurg. 108(5):1063-4; author reply 1064-5, 2008
Takeuchi H et al: A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology. 28(1):98-102, 2008
Innus C et al: Hemangioblastoma without von Hippel-Lindau disease. JAAPA. 20(11):28, 31-2, 2007
Hoang MP et al: Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am J Surg Pathol. 27(8):1152-6, 2003
Reyns N et al: Leptomeningeal hemangioblastomatosis in a case of von Hippel-Lindau disease: case report. Neurosurgery. 52(5):1212-5; discussion 1215-6, 2003
Sarkar C et al: August 2002: 21-year-old male with cystic intracerebral tumor. Brain Pathol. 13(1):113-4, 117, 2003
Wanebo JE et al: The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg. 98(1):82-94, 2003
Weil RJ et al: Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel-Lindau disease. Report of four cases. J Neurosurg. 96(4):775-87, 2002
Conway JE et al: Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 48(1):55-62; discussion 62-3, 2001
Kondo T et al: Diagnostic value of 201Tl-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas. J Neurosurg. 95(2):292-7, 2001
Wang C et al: Surgical management of medullary hemangioblastoma. Report of 47 cases. Surg Neurol. 56(4):218-26; discussion 226-7, 2001
Bohling T et al: von Hippel-Lindau disease and capillary hemangioblastoma. In Kleihues P et al: Tumours of the Nervous System. Lyon: IARC Press. 223-6, 2000
Miyagami M et al: Clinicopathological study of vascular endothelial growth factor (VEGF), p53, and proliferative potential in familial von Hippel-Lindau disease and sporadic hemangioblastomas. Brain Tumor Pathol. 17(3):111-20, 2000
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