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Hemangioendothelioma: Osseous
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Hemangioendothelial sarcoma, low-grade angiosarcoma
          • Definitions

            • Intraosseous vascular tumor of endothelial origin which may be of intermediate or indeterminate malignancy
              • Unlike hemangioma, considered true neoplasm (independent growth potential, nuclear atypia)

          IMAGING

          • General Features

            • Radiographic Findings

              • MR Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • Gross Pathologic & Surgical Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              Selected References

                              1. Davis AT et al: A novel treatment for bone lesions of multifocal epithelioid sarcoma-like hemangioendothelioma. Skeletal Radiol. ePub, 2015
                              2. Angelini A et al: Surgical treatment and results of 62 patients with epithelioid hemangioendothelioma of bone. J Surg Oncol. 109(8):791-7, 2014
                              3. Luzzati A et al: Epithelioid hemangioendothelioma of the spine: results at seven years of average follow-up in a series of 10 cases surgically treated and a review of literature. Eur Spine J. ePub, 2014
                              4. Treglia G et al: Multifocal epithelioid hemangioendothelioma of the lower limbs detected by 18F-FDG PET/MRI. Clin Nucl Med. 39(9):e402-4, 2014
                              5. Weissferdt A et al: Epithelioid hemangioendothelioma of the bone: a review and update. Adv Anat Pathol. 21(4):254-9, 2014
                              6. Ravi V et al: Vascular sarcomas. Curr Oncol Rep. 15(4):347-55, 2013
                              7. Errani C et al: Vascular bone tumors: a proposal of a classification based on clinicopathological, radiographic and genetic features. Skeletal Radiol. 41(12):1495-507, 2012
                              8. Wang CG et al: Epithelioid hemangioendothelioma of thoracic vertebra: a case report (2008: 11b). Eur Radiol. 19(2):517-20, 2009
                              9. Kopniczky Z et al: Epithelioid hemangioendothelioma of the spine: report of two cases and review of the literature. Br J Neurosurg. 22(6):793-7, 2008
                              10. Luna JT et al: Five-year follow-up of structural allograft reconstruction for epithelioid hemangioma of the talus and navicular: a case report and review of the literature. Foot Ankle Int. 28(3):379-84, 2007
                              11. Bruegel M et al: Multifocal epithelioid hemangioendothelioma of the phalanges of the hand. Skeletal Radiol. 35(10):787-92, 2006
                              12. Floris G et al: Epithelioid hemangioma of bone: a potentially metastasizing tumor? Int J Surg Pathol. 14(1):9-15; discussion 16-20, 2006
                              13. Adler B et al: Multifocal epithelioid hemangioendothelioma in a 16-year-old boy. Pediatr Radiol. 35(10):1014-8, 2005
                              14. Shah ZK et al: Hemangioendothelioma with an epithelioid phenotype arising in hemangioma of the fibula. Skeletal Radiol. 34(11):750-4, 2005
                              15. Vilanova JC et al: Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics. 24(2):367-85, 2004
                              16. Evans HL et al: Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol. 34(7):680-9, 2003
                              17. Rosenthal DI et al: Treatment of epithelioid hemangioendothelioma of bone using a novel combined approach. Skeletal Radiol. 30(4):219-22, 2001
                              18. Choi JJ et al: Angiomatous skeletal lesions. Semin Musculoskelet Radiol. 4(1):103-12, 2000
                              19. Sung MS et al: Epithelioid hemangioma of bone. Skeletal Radiol. 29(9):530-4, 2000
                              20. Wenger DE et al: Malignant vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol. 29(11):619-31, 2000
                              21. Camarero A et al: Multicentric epithelioidal hemangioendothelioma of bone: diagnostic imaging. Clin Nucl Med. 24(12):1002-4, 1999
                              22. Greenspan A et al: Differential diagnosis of tumors and tumor-like lesions of bones and joints. 301-4. Philadelphia: Lippincott-Raven, 1998
                              23. Boutin RD et al: Epithelioid hemangioendothelioma of bone. Skeletal Radiol. 25(4):391-5, 1996
                              24. Kleer CG et al: Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 20(11):1301-11, 1996
                              25. Lomasney LM et al: Multifocal vascular lesions of bone: imaging characteristics. Skeletal Radiol. 25(3):255-61, 1996
                              26. Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Pathology

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Synonyms

                                        • Hemangioendothelial sarcoma, low-grade angiosarcoma
                                      • Definitions

                                        • Intraosseous vascular tumor of endothelial origin which may be of intermediate or indeterminate malignancy
                                          • Unlike hemangioma, considered true neoplasm (independent growth potential, nuclear atypia)

                                      IMAGING

                                      • General Features

                                        • Radiographic Findings

                                          • MR Findings

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • Gross Pathologic & Surgical Features

                                                • Microscopic Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          Selected References

                                                          1. Davis AT et al: A novel treatment for bone lesions of multifocal epithelioid sarcoma-like hemangioendothelioma. Skeletal Radiol. ePub, 2015
                                                          2. Angelini A et al: Surgical treatment and results of 62 patients with epithelioid hemangioendothelioma of bone. J Surg Oncol. 109(8):791-7, 2014
                                                          3. Luzzati A et al: Epithelioid hemangioendothelioma of the spine: results at seven years of average follow-up in a series of 10 cases surgically treated and a review of literature. Eur Spine J. ePub, 2014
                                                          4. Treglia G et al: Multifocal epithelioid hemangioendothelioma of the lower limbs detected by 18F-FDG PET/MRI. Clin Nucl Med. 39(9):e402-4, 2014
                                                          5. Weissferdt A et al: Epithelioid hemangioendothelioma of the bone: a review and update. Adv Anat Pathol. 21(4):254-9, 2014
                                                          6. Ravi V et al: Vascular sarcomas. Curr Oncol Rep. 15(4):347-55, 2013
                                                          7. Errani C et al: Vascular bone tumors: a proposal of a classification based on clinicopathological, radiographic and genetic features. Skeletal Radiol. 41(12):1495-507, 2012
                                                          8. Wang CG et al: Epithelioid hemangioendothelioma of thoracic vertebra: a case report (2008: 11b). Eur Radiol. 19(2):517-20, 2009
                                                          9. Kopniczky Z et al: Epithelioid hemangioendothelioma of the spine: report of two cases and review of the literature. Br J Neurosurg. 22(6):793-7, 2008
                                                          10. Luna JT et al: Five-year follow-up of structural allograft reconstruction for epithelioid hemangioma of the talus and navicular: a case report and review of the literature. Foot Ankle Int. 28(3):379-84, 2007
                                                          11. Bruegel M et al: Multifocal epithelioid hemangioendothelioma of the phalanges of the hand. Skeletal Radiol. 35(10):787-92, 2006
                                                          12. Floris G et al: Epithelioid hemangioma of bone: a potentially metastasizing tumor? Int J Surg Pathol. 14(1):9-15; discussion 16-20, 2006
                                                          13. Adler B et al: Multifocal epithelioid hemangioendothelioma in a 16-year-old boy. Pediatr Radiol. 35(10):1014-8, 2005
                                                          14. Shah ZK et al: Hemangioendothelioma with an epithelioid phenotype arising in hemangioma of the fibula. Skeletal Radiol. 34(11):750-4, 2005
                                                          15. Vilanova JC et al: Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics. 24(2):367-85, 2004
                                                          16. Evans HL et al: Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol. 34(7):680-9, 2003
                                                          17. Rosenthal DI et al: Treatment of epithelioid hemangioendothelioma of bone using a novel combined approach. Skeletal Radiol. 30(4):219-22, 2001
                                                          18. Choi JJ et al: Angiomatous skeletal lesions. Semin Musculoskelet Radiol. 4(1):103-12, 2000
                                                          19. Sung MS et al: Epithelioid hemangioma of bone. Skeletal Radiol. 29(9):530-4, 2000
                                                          20. Wenger DE et al: Malignant vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol. 29(11):619-31, 2000
                                                          21. Camarero A et al: Multicentric epithelioidal hemangioendothelioma of bone: diagnostic imaging. Clin Nucl Med. 24(12):1002-4, 1999
                                                          22. Greenspan A et al: Differential diagnosis of tumors and tumor-like lesions of bones and joints. 301-4. Philadelphia: Lippincott-Raven, 1998
                                                          23. Boutin RD et al: Epithelioid hemangioendothelioma of bone. Skeletal Radiol. 25(4):391-5, 1996
                                                          24. Kleer CG et al: Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 20(11):1301-11, 1996
                                                          25. Lomasney LM et al: Multifocal vascular lesions of bone: imaging characteristics. Skeletal Radiol. 25(3):255-61, 1996
                                                          26. Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995