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Hemangiopericytoma
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Hemangiopericytoma (HPC), meningeal hemangiopericytoma
              • Synonyms

                • In older literature called "angioblastic meningioma," hemangiopericytic type
                • New literature supports the term solitary fibrous tumor (SFT), hemangiocytoma type, cellular SFT or malignant SFT
              • Definitions

                • Highly cellular and vascularized mesenchymal tumor, nearly always attached to dura
                • Sarcoma related to neoplastic transformation of pericytes, contractile cells about capillaries
                  • Occur in any region of body where capillaries are found

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Angiographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Nakada S et al: NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases. Brain Tumor Pathol. ePub, 2015
                                                2. Damodaran O et al: Primary intracranial haemangiopericytoma: comparison of survival outcomes and metastatic potential in WHO grade II and III variants. J Clin Neurosci. 21(8):1310-4, 2014
                                                3. Ghose A et al: CNS Hemangiopericytoma: A Systematic Review of 523 Patients. Am J Clin Oncol. ePub, 2014
                                                4. Liu L et al: Comparison of ADC values of intracranial hemangiopericytomas and angiomatous and anaplastic meningiomas. J Neuroradiol. 41(3):188-94, 2014
                                                5. McHugh BJ et al: Intracranial infantile hemangiopericytoma. J Neurosurg Pediatr. 14(2):149-54, 2014
                                                6. Smith AB et al: From the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic-pathologic correlation. Radiographics. 34(2):295-312, 2014
                                                7. Sonabend AM et al: The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis. J Neurosurg. 120(2):300-8, 2014
                                                8. Liu G et al: Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values. J Magn Reson Imaging. 38(5):1146-51, 2013
                                                9. Tian R et al: Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases. J Neurooncol. 115(1):53-9, 2013
                                                10. Chernov MF et al: Possible role of single-voxel (1)H-MRS in differential diagnosis of suprasellar tumors. J Neurooncol. 91(2):191-8, 2009
                                                11. Fitzpatrick D et al: Intradural hemangiopericytoma of the lumbar spine: a rare entity. AJNR Am J Neuroradiol. 30(1):152-4, 2009
                                                12. Hayashi Y et al: A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system. Clin Neurol Neurosurg. 111(1):34-8, 2009
                                                13. Park MS et al: New insights into the hemangiopericytoma/solitary fibrous tumor spectrum of tumors. Curr Opin Oncol. 21(4):327-31, 2009
                                                14. Shi ZP et al: Multiple metastatic progression of meningeal hemangiopericytoma initially diagnosed as atypical meningioma with temporal bone invasion. Otolaryngol Head Neck Surg. 140(2):278-80, 2009
                                                15. Wu W et al: Hemangiopericytomas in the central nervous system. J Clin Neurosci. 16(4):519-23, 2009
                                                16. Chamberlain MC et al: Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery. 63(4):720-6; author reply 726-7, 2008
                                                17. Jalali R et al: Suprasellar haemangiopericytoma--challenges in diagnosis and treatment. Acta Neurochir (Wien). 150(1):67-71, 2008
                                                18. Mathews MS et al: Klippel-Trenaunay syndrome and cerebral haemangiopericytoma: a potential association. Acta Neurochir (Wien). 150(4):399-402; discussion 402, 2008
                                                19. Mekni A et al: Hemangiopericytoma in the central nervous system. A study of eight cases. Neurochirurgie. 54(1):15-20, 2008
                                                20. Scheithauer BW et al: The 2007 WHO classification of tumors of the nervous system: controversies in surgical neuropathology. Brain Pathol. 2008 Jul;18(3):307-16. Erratum in: Brain Pathol. 18(4):640, 2008
                                                21. Juco J et al: Hemangiopericytoma of the sella mimicking pituitary adenoma: case report and review of the literature. Clin Neuropathol. 26(6):288-93, 2007
                                                22. Louis DN et al: WHO Classification of Tumours of the CNS: Haemangiopericytoma. Lyon: IARC Press. 178-80, 2007
                                                23. Sibtain NA et al: Imaging features of central nervous system haemangiopericytomas. Eur Radiol. 17(7):1685-93, 2007
                                                24. Fountas KN et al: Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev. 29(2):145-53, 2006
                                                25. Lee JK et al: Spinal metastasis from cranial meningeal hemangiopericytomas. Acta Neurochir (Wien). 148(7):787-90, 2006
                                                26. Lin SH et al: Diagnosis and treatment of sinonasal hemangiopericytoma: Three case reports and review of the literature. J Otolaryngol. 35(2):141-3, 2006
                                                27. Folpe AL et al: Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol. 28(1):1-30, 2004
                                                28. Ecker RD et al: Hemangiopericytoma in the central nervous system: treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg. 98(6):1182-7, 2003
                                                29. Kim JH et al: Meningeal hemangiopericytomas: long-term outcome and biological behavior. Surg Neurol. 59(1):47-53; discussion 53-4, 2003
                                                30. Tihan T et al: Solitary fibrous tumors in the central nervous system. A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas. Arch Pathol Lab Med. 127(4):432-9, 2003
                                                31. Burger PC et al: Surgical pathology of the nervous system and its coverings: Intracranial meninges. 4th ed. Philadelphia: Churchill Livingstone. 79-83, 2002
                                                32. Cavalheiro S et al: Fetal meningeal hemangiopericytoma. Case report. J Neurosurg. 97(5):1217-20, 2002
                                                33. Johnson MD et al: Dural lesions mimicking meningiomas. Hum Pathol. 33(12):1211-26, 2002
                                                34. Alen JF et al: Intracranial hemangiopericytoma: study of 12 cases. Acta Neurochir (Wien). 143(6):575-86, 2001
                                                35. Barba I et al: Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. J Neurosurg. 94(1):55-60, 2001
                                                36. Dufour H et al: Meningeal hemangiopericytoma: a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery. 48(4):756-62; discussion 762-3, 2001
                                                37. Tan I et al: Haemangiopericytoma of the trigeminal nerve. Australas Radiol. 45(3):350-3, 2001
                                                38. Huisman TA et al: Meningeal hemangiopericytoma in childhood. Eur Radiol. 10(7):1073-5, 2000
                                                39. Jaaskelainen J et al: Pathology and genetics of tumours of the nervous system: Haemangiopericytoma. Lyon: IARC Press. 190-2, 2000
                                                40. Kracht LW et al: Positron emission tomography in a case of intracranial hemangiopericytoma. J Comput Assist Tomogr. 23(3):365-8, 1999
                                                41. Galanis E et al: Management of recurrent meningeal hemangiopericytoma. Cancer. 82(10):1915-20, 1998
                                                42. Spitz FR et al: Hemangiopericytoma: a 20-year single-institution experience. Ann Surg Oncol. 5(4):350-5, 1998
                                                43. Chiechi MV et al: Intracranial hemangiopericytomas: MR and CT features. AJNR Am J Neuroradiol. 17(7):1365-71, 1996
                                                44. Zattara-Cannoni H et al: The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma. J Neurooncol. 29(2):137-42, 1996
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Pathology

                                                        • Clinical Issues

                                                          • Diagnostic Checklist

                                                            TERMINOLOGY

                                                            • Abbreviations

                                                              • Hemangiopericytoma (HPC), meningeal hemangiopericytoma
                                                            • Synonyms

                                                              • In older literature called "angioblastic meningioma," hemangiopericytic type
                                                              • New literature supports the term solitary fibrous tumor (SFT), hemangiocytoma type, cellular SFT or malignant SFT
                                                            • Definitions

                                                              • Highly cellular and vascularized mesenchymal tumor, nearly always attached to dura
                                                              • Sarcoma related to neoplastic transformation of pericytes, contractile cells about capillaries
                                                                • Occur in any region of body where capillaries are found

                                                            IMAGING

                                                            • General Features

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Angiographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Nakada S et al: NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases. Brain Tumor Pathol. ePub, 2015
                                                                                              2. Damodaran O et al: Primary intracranial haemangiopericytoma: comparison of survival outcomes and metastatic potential in WHO grade II and III variants. J Clin Neurosci. 21(8):1310-4, 2014
                                                                                              3. Ghose A et al: CNS Hemangiopericytoma: A Systematic Review of 523 Patients. Am J Clin Oncol. ePub, 2014
                                                                                              4. Liu L et al: Comparison of ADC values of intracranial hemangiopericytomas and angiomatous and anaplastic meningiomas. J Neuroradiol. 41(3):188-94, 2014
                                                                                              5. McHugh BJ et al: Intracranial infantile hemangiopericytoma. J Neurosurg Pediatr. 14(2):149-54, 2014
                                                                                              6. Smith AB et al: From the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic-pathologic correlation. Radiographics. 34(2):295-312, 2014
                                                                                              7. Sonabend AM et al: The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis. J Neurosurg. 120(2):300-8, 2014
                                                                                              8. Liu G et al: Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values. J Magn Reson Imaging. 38(5):1146-51, 2013
                                                                                              9. Tian R et al: Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases. J Neurooncol. 115(1):53-9, 2013
                                                                                              10. Chernov MF et al: Possible role of single-voxel (1)H-MRS in differential diagnosis of suprasellar tumors. J Neurooncol. 91(2):191-8, 2009
                                                                                              11. Fitzpatrick D et al: Intradural hemangiopericytoma of the lumbar spine: a rare entity. AJNR Am J Neuroradiol. 30(1):152-4, 2009
                                                                                              12. Hayashi Y et al: A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system. Clin Neurol Neurosurg. 111(1):34-8, 2009
                                                                                              13. Park MS et al: New insights into the hemangiopericytoma/solitary fibrous tumor spectrum of tumors. Curr Opin Oncol. 21(4):327-31, 2009
                                                                                              14. Shi ZP et al: Multiple metastatic progression of meningeal hemangiopericytoma initially diagnosed as atypical meningioma with temporal bone invasion. Otolaryngol Head Neck Surg. 140(2):278-80, 2009
                                                                                              15. Wu W et al: Hemangiopericytomas in the central nervous system. J Clin Neurosci. 16(4):519-23, 2009
                                                                                              16. Chamberlain MC et al: Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery. 63(4):720-6; author reply 726-7, 2008
                                                                                              17. Jalali R et al: Suprasellar haemangiopericytoma--challenges in diagnosis and treatment. Acta Neurochir (Wien). 150(1):67-71, 2008
                                                                                              18. Mathews MS et al: Klippel-Trenaunay syndrome and cerebral haemangiopericytoma: a potential association. Acta Neurochir (Wien). 150(4):399-402; discussion 402, 2008
                                                                                              19. Mekni A et al: Hemangiopericytoma in the central nervous system. A study of eight cases. Neurochirurgie. 54(1):15-20, 2008
                                                                                              20. Scheithauer BW et al: The 2007 WHO classification of tumors of the nervous system: controversies in surgical neuropathology. Brain Pathol. 2008 Jul;18(3):307-16. Erratum in: Brain Pathol. 18(4):640, 2008
                                                                                              21. Juco J et al: Hemangiopericytoma of the sella mimicking pituitary adenoma: case report and review of the literature. Clin Neuropathol. 26(6):288-93, 2007
                                                                                              22. Louis DN et al: WHO Classification of Tumours of the CNS: Haemangiopericytoma. Lyon: IARC Press. 178-80, 2007
                                                                                              23. Sibtain NA et al: Imaging features of central nervous system haemangiopericytomas. Eur Radiol. 17(7):1685-93, 2007
                                                                                              24. Fountas KN et al: Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev. 29(2):145-53, 2006
                                                                                              25. Lee JK et al: Spinal metastasis from cranial meningeal hemangiopericytomas. Acta Neurochir (Wien). 148(7):787-90, 2006
                                                                                              26. Lin SH et al: Diagnosis and treatment of sinonasal hemangiopericytoma: Three case reports and review of the literature. J Otolaryngol. 35(2):141-3, 2006
                                                                                              27. Folpe AL et al: Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol. 28(1):1-30, 2004
                                                                                              28. Ecker RD et al: Hemangiopericytoma in the central nervous system: treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg. 98(6):1182-7, 2003
                                                                                              29. Kim JH et al: Meningeal hemangiopericytomas: long-term outcome and biological behavior. Surg Neurol. 59(1):47-53; discussion 53-4, 2003
                                                                                              30. Tihan T et al: Solitary fibrous tumors in the central nervous system. A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas. Arch Pathol Lab Med. 127(4):432-9, 2003
                                                                                              31. Burger PC et al: Surgical pathology of the nervous system and its coverings: Intracranial meninges. 4th ed. Philadelphia: Churchill Livingstone. 79-83, 2002
                                                                                              32. Cavalheiro S et al: Fetal meningeal hemangiopericytoma. Case report. J Neurosurg. 97(5):1217-20, 2002
                                                                                              33. Johnson MD et al: Dural lesions mimicking meningiomas. Hum Pathol. 33(12):1211-26, 2002
                                                                                              34. Alen JF et al: Intracranial hemangiopericytoma: study of 12 cases. Acta Neurochir (Wien). 143(6):575-86, 2001
                                                                                              35. Barba I et al: Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. J Neurosurg. 94(1):55-60, 2001
                                                                                              36. Dufour H et al: Meningeal hemangiopericytoma: a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery. 48(4):756-62; discussion 762-3, 2001
                                                                                              37. Tan I et al: Haemangiopericytoma of the trigeminal nerve. Australas Radiol. 45(3):350-3, 2001
                                                                                              38. Huisman TA et al: Meningeal hemangiopericytoma in childhood. Eur Radiol. 10(7):1073-5, 2000
                                                                                              39. Jaaskelainen J et al: Pathology and genetics of tumours of the nervous system: Haemangiopericytoma. Lyon: IARC Press. 190-2, 2000
                                                                                              40. Kracht LW et al: Positron emission tomography in a case of intracranial hemangiopericytoma. J Comput Assist Tomogr. 23(3):365-8, 1999
                                                                                              41. Galanis E et al: Management of recurrent meningeal hemangiopericytoma. Cancer. 82(10):1915-20, 1998
                                                                                              42. Spitz FR et al: Hemangiopericytoma: a 20-year single-institution experience. Ann Surg Oncol. 5(4):350-5, 1998
                                                                                              43. Chiechi MV et al: Intracranial hemangiopericytomas: MR and CT features. AJNR Am J Neuroradiol. 17(7):1365-71, 1996
                                                                                              44. Zattara-Cannoni H et al: The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma. J Neurooncol. 29(2):137-42, 1996