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Hematopoietic Stem Cell Transplantation
Carol C. Wu, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Hematopoietic stem cell transplantation (HSCT)
          • Definitions

            • HSCT
              • Types
                • Bone marrow transplantation, peripheral blood stem cell transplantation, cord blood stem cell transplantation
                • Autologous transplantation uses patient's own stem cells
                • Allogeneic transplantation uses cells from human leukocyte antigen-consistent donor
              • Procedure
                • Intensive chemotherapy & total body irradiation (TBI) to eradicate recipient's malignant cells
                • TBI followed by infusion of donor's hematopoietic stem cells
              • Complications
                • Graft-vs.-host disease (GVHD): Donor T lymphocytes attack recipient's organs as foreign bodies, occurs with allogeneic transplantation

          IMAGING

          • General Features

            • Neutropenic (Engraftment) Phase

              • Early Phase

                • Late Phase

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Demographics

                          • Engraftment Syndrome

                            • Diffuse Alveolar Hemorrhage

                              • CMV Pneumonia

                                • Idiopathic Pneumonia Syndrome

                                  • Graft-vs.-Host Disease (GVHD)

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Tanaka N et al: High-resolution computed tomography of chest complications in patients treated with hematopoietic stem cell transplantation. Jpn J Radiol. 29(4):229-35, 2011
                                      2. Jagannathan JP et al: Imaging of complications of hematopoietic stem cell transplantation. Radiol Clin North Am. 46(2):397-417, x, 2008
                                      3. Coy DL et al: Imaging evaluation of pulmonary and abdominal complications following hematopoietic stem cell transplantation. Radiographics. 25(2):305-17; discussion 318, 2005
                                      4. Evans A et al: Imaging in haematopoietic stem cell transplantation. Clin Radiol. 58(3):201-14, 2003
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Hematopoietic stem cell transplantation (HSCT)
                                              • Definitions

                                                • HSCT
                                                  • Types
                                                    • Bone marrow transplantation, peripheral blood stem cell transplantation, cord blood stem cell transplantation
                                                    • Autologous transplantation uses patient's own stem cells
                                                    • Allogeneic transplantation uses cells from human leukocyte antigen-consistent donor
                                                  • Procedure
                                                    • Intensive chemotherapy & total body irradiation (TBI) to eradicate recipient's malignant cells
                                                    • TBI followed by infusion of donor's hematopoietic stem cells
                                                  • Complications
                                                    • Graft-vs.-host disease (GVHD): Donor T lymphocytes attack recipient's organs as foreign bodies, occurs with allogeneic transplantation

                                              IMAGING

                                              • General Features

                                                • Neutropenic (Engraftment) Phase

                                                  • Early Phase

                                                    • Late Phase

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Demographics

                                                              • Engraftment Syndrome

                                                                • Diffuse Alveolar Hemorrhage

                                                                  • CMV Pneumonia

                                                                    • Idiopathic Pneumonia Syndrome

                                                                      • Graft-vs.-Host Disease (GVHD)

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Tanaka N et al: High-resolution computed tomography of chest complications in patients treated with hematopoietic stem cell transplantation. Jpn J Radiol. 29(4):229-35, 2011
                                                                          2. Jagannathan JP et al: Imaging of complications of hematopoietic stem cell transplantation. Radiol Clin North Am. 46(2):397-417, x, 2008
                                                                          3. Coy DL et al: Imaging evaluation of pulmonary and abdominal complications following hematopoietic stem cell transplantation. Radiographics. 25(2):305-17; discussion 318, 2005
                                                                          4. Evans A et al: Imaging in haematopoietic stem cell transplantation. Clin Radiol. 58(3):201-14, 2003