Autologous transplantation uses patient's own stem cells
Allogeneic transplantation uses cells from human leukocyte antigen-consistent donor
Procedure
High-dose chemotherapy &/or total body irradiation (TBI) followed by infusion of donor hematopoietic stem cells
Complications
Infectious and noninfectious
Noninfectious:Graft-vs.-host disease (GVHD); donor T-lymphocytes attack recipient's organs as foreign bodies, occurs with allogeneic transplantation
IMAGING
General Features
Early Phase: Neutropenic (Pre-Engraftment) 0-30 Days
Early Phase: Early Posttransplant (30-100 Days)
Late Phase (> 100 Days)
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Demographics
Graft-vs.-Host Disease
DIAGNOSTIC CHECKLIST
Consider
Selected References
Haider S et al: Noninfectious pulmonary complications of haematopoietic stem cell transplantation. Eur Respir Rev. 29(156), 2020
Boghanim T et al: Thoracic air-leak syndrome complicating allogeneic hematopoietic stem-cell transplantation. Lung. 197(1):101-3, 2019
Bondeelle L et al: Managing pulmonary complications in allogeneic hematopoietic stem cell transplantation. Expert Rev Respir Med. 13(1):105-19, 2019
Shroff GS et al: Imaging of pneumonias and other thoracic complications after hematopoietic stem cell transplantation. Curr Probl Diagn Radiol. 48(4):393-401, 2019
Tanaka N et al: High-resolution computed tomography of chest complications in patients treated with hematopoietic stem cell transplantation. Jpn J Radiol. 29(4):229-35, 2011
Autologous transplantation uses patient's own stem cells
Allogeneic transplantation uses cells from human leukocyte antigen-consistent donor
Procedure
High-dose chemotherapy &/or total body irradiation (TBI) followed by infusion of donor hematopoietic stem cells
Complications
Infectious and noninfectious
Noninfectious:Graft-vs.-host disease (GVHD); donor T-lymphocytes attack recipient's organs as foreign bodies, occurs with allogeneic transplantation
IMAGING
General Features
Early Phase: Neutropenic (Pre-Engraftment) 0-30 Days
Early Phase: Early Posttransplant (30-100 Days)
Late Phase (> 100 Days)
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Demographics
Graft-vs.-Host Disease
DIAGNOSTIC CHECKLIST
Consider
Selected References
Haider S et al: Noninfectious pulmonary complications of haematopoietic stem cell transplantation. Eur Respir Rev. 29(156), 2020
Boghanim T et al: Thoracic air-leak syndrome complicating allogeneic hematopoietic stem-cell transplantation. Lung. 197(1):101-3, 2019
Bondeelle L et al: Managing pulmonary complications in allogeneic hematopoietic stem cell transplantation. Expert Rev Respir Med. 13(1):105-19, 2019
Shroff GS et al: Imaging of pneumonias and other thoracic complications after hematopoietic stem cell transplantation. Curr Probl Diagn Radiol. 48(4):393-401, 2019
Tanaka N et al: High-resolution computed tomography of chest complications in patients treated with hematopoietic stem cell transplantation. Jpn J Radiol. 29(4):229-35, 2011
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.