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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Definitions
- Iron overload disorder in which there is structural and functional impairment of involved organs
- Hemosiderosis: ↑ iron deposition without organ damage
- Usually seen with body iron stores of 10-20 g
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- França M et al: MR imaging assessment and quantification of liver iron. Abdom Radiol (NY). 45(11):3400-12, 2020
- Kowdley KV et al: ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 114(8):1202-18, 2019
- Yamauchi R et al: Hepatocellular carcinoma arising in a non-cirrhotic liver with secondary hemochromatosis. Intern Med. 58(5):661-5, 2019
- Golfeyz S et al: Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI. Expert Rev Gastroenterol Hepatol. 12(8):767-78, 2018
- Labranche R et al: Liver iron quantification with mr imaging: a primer for radiologists. Radiographics. 38(2):392-412, 2018
- Radford-Smith DE et al: Haemochromatosis: a clinical update for the practising physician. Intern Med J. 48(5):509-16, 2018
- Ros PR et al: Imaging of diffuse and inflammatory liver disease, 2018
- Yan F et al: Iron deposition quantification: applications in the brain and liver. J Magn Reson Imaging. 48(2):301-17, 2018
- Sharma SD et al: MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med. 78(1):264-70, 2017
- Ekanayake D et al: Recent advances in hemochromatosis: a 2015 update: a summary of proceedings of the 2014 conference held under the auspices of Hemochromatosis Australia. Hepatol Int. 9(2):174-82, 2015
- Salgia RJ et al: Diagnosis and management of hereditary hemochromatosis. Clin Liver Dis. 19(1):187-98, 2015
- Leitman SF: Hemochromatosis: the new blood donor. Hematology Am Soc Hematol Educ Program. 2013:645-50, 2013
- Sirlin CB et al: Magnetic resonance imaging quantification of liver iron. Magn Reson Imaging Clin N Am. 18(3):359-81, 2010
- Queiroz-Andrade M et al: MR imaging findings of iron overload. Radiographics. 29(6):1575-89, 2009
- Bassett ML et al: The changing role of liver biopsy in diagnosis and management of haemochromatosis. Pathology. 43(5):433-9, 2011
- Babitt JL et al: The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis. 31(3):280-92, 2011
- Deugnier Y et al: Pathology of hepatic iron overload. Semin Liver Dis. 31(3):260-71, 2011
- Gan EK et al: Natural history and management of HFE-hemochromatosis. Semin Liver Dis. 31(3):293-301, 2011
- Papakonstantinou O et al: Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major. J Magn Reson Imaging. 29(4):853-9, 2009
- Thachil J: Screening strategies for hemochromatosis. Ann Intern Med. 150(8):566, 2009
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Diagnostic Checklist
TERMINOLOGY
Definitions
- Iron overload disorder in which there is structural and functional impairment of involved organs
- Hemosiderosis: ↑ iron deposition without organ damage
- Usually seen with body iron stores of 10-20 g
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- França M et al: MR imaging assessment and quantification of liver iron. Abdom Radiol (NY). 45(11):3400-12, 2020
- Kowdley KV et al: ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 114(8):1202-18, 2019
- Yamauchi R et al: Hepatocellular carcinoma arising in a non-cirrhotic liver with secondary hemochromatosis. Intern Med. 58(5):661-5, 2019
- Golfeyz S et al: Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI. Expert Rev Gastroenterol Hepatol. 12(8):767-78, 2018
- Labranche R et al: Liver iron quantification with mr imaging: a primer for radiologists. Radiographics. 38(2):392-412, 2018
- Radford-Smith DE et al: Haemochromatosis: a clinical update for the practising physician. Intern Med J. 48(5):509-16, 2018
- Ros PR et al: Imaging of diffuse and inflammatory liver disease, 2018
- Yan F et al: Iron deposition quantification: applications in the brain and liver. J Magn Reson Imaging. 48(2):301-17, 2018
- Sharma SD et al: MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med. 78(1):264-70, 2017
- Ekanayake D et al: Recent advances in hemochromatosis: a 2015 update: a summary of proceedings of the 2014 conference held under the auspices of Hemochromatosis Australia. Hepatol Int. 9(2):174-82, 2015
- Salgia RJ et al: Diagnosis and management of hereditary hemochromatosis. Clin Liver Dis. 19(1):187-98, 2015
- Leitman SF: Hemochromatosis: the new blood donor. Hematology Am Soc Hematol Educ Program. 2013:645-50, 2013
- Sirlin CB et al: Magnetic resonance imaging quantification of liver iron. Magn Reson Imaging Clin N Am. 18(3):359-81, 2010
- Queiroz-Andrade M et al: MR imaging findings of iron overload. Radiographics. 29(6):1575-89, 2009
- Bassett ML et al: The changing role of liver biopsy in diagnosis and management of haemochromatosis. Pathology. 43(5):433-9, 2011
- Babitt JL et al: The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis. 31(3):280-92, 2011
- Deugnier Y et al: Pathology of hepatic iron overload. Semin Liver Dis. 31(3):260-71, 2011
- Gan EK et al: Natural history and management of HFE-hemochromatosis. Semin Liver Dis. 31(3):293-301, 2011
- Papakonstantinou O et al: Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major. J Magn Reson Imaging. 29(4):853-9, 2009
- Thachil J: Screening strategies for hemochromatosis. Ann Intern Med. 150(8):566, 2009
