link
Bookmarks
Pediatrics
Diagnosis
Genitourinary
Miscellaneous Renal Conditions
Hemolytic Uremic Syndrome
Hemolytic Uremic Syndrome
A. Carlson Merrow, Jr., MD, FAAP
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
0
0
3
0

KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Hemolytic uremic syndrome (HUS)

        • Definitions

          • Thrombotic microangiopathy typically occurring after gastrointestinal infection with Shiga toxin-producing bacteria (classically Escherichia coli O157:H7)
          • Clinical triad of hemolytic anemia, thrombocytopenia, & acute renal failure following severe diarrhea
            • Affected organ systems: Kidneys > CNS (20-50%) > gastrointestinal tract, heart
          • Atypical form (HUS without coexisting disease) often due to dysregulation in alternative complement pathway
            • Diarrhea less common; ↑ mortality

        IMAGING

        • General Features

          DIFFERENTIAL DIAGNOSIS

            PATHOLOGY

            • General Features

              • Microscopic Features

                CLINICAL ISSUES

                • Presentation

                  • Demographics

                    • Natural History & Prognosis

                      • Treatment

                        Selected References

                        1. Cody EM et al: Hemolytic uremic syndrome. Pediatr Clin North Am. 66(1):235-46, 2019
                        2. Herrmann J et al: Diffusion-weighted imaging of the kidneys in haemolytic uraemic syndrome. Eur Radiol. 27(11):4591-601, 2017
                        3. Löbel U et al: Cerebral hemodynamics in patients with hemolytic uremic syndrome assessed by susceptibility weighted imaging and four-dimensional non-contrast MR angiography. PLoS One. 11(11):e0164863, 2016
                        4. Reising A et al: Ultrasound findings in EHEC-associated hemolytic-uremic syndrome and their clinical relevance. Int Urol Nephrol. 48(4):561-70, 2016
                        5. Keir LS: Shiga toxin associated hemolytic uremic syndrome. Hematol Oncol Clin North Am. 29(3):525-39, 2015
                        6. Agarwal R et al: Posterior reversible encephalopathy and cerebral vasoconstriction in a patient with hemolytic uremic syndrome. Pediatr Neurol. 50(5):518-21, 2014
                        7. Hofer J et al: Extra-renal manifestations of complement-mediated thrombotic microangiopathies. Front Pediatr. 2:97, 2014
                        8. Kaplan BS et al: Current treatment of atypical hemolytic uremic syndrome. Intractable Rare Dis Res. 3(2):34-45, 2014
                        9. Gitiaux C et al: Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab. Dev Med Child Neurol. 55(8):758-65, 2013
                        10. Glatstein M et al: Timing and utility of ultrasound in diarrhea-associated hemolytic uremic syndrome: 7-year experience of a large tertiary care hospital. Clin Pediatr (Phila). 49(5):418-21, 2010
                        11. Toldo I et al: Diffusion-weighted imaging findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol. 24(2):247-50, 2009
                        12. Scholbach TM: Changes of renal flow volume in the hemolytic-uremic syndrome--color Doppler sonographic investigations. Pediatr Nephrol. 16(8):644-7, 2001
                        Related Anatomy
                        Loading...
                        Related Differential Diagnoses
                        Loading...
                        References
                        Tables

                        Tables

                        KEY FACTS

                        • Terminology

                          • Imaging

                            • Clinical Issues

                              TERMINOLOGY

                              • Abbreviations

                                • Hemolytic uremic syndrome (HUS)

                              • Definitions

                                • Thrombotic microangiopathy typically occurring after gastrointestinal infection with Shiga toxin-producing bacteria (classically Escherichia coli O157:H7)
                                • Clinical triad of hemolytic anemia, thrombocytopenia, & acute renal failure following severe diarrhea
                                  • Affected organ systems: Kidneys > CNS (20-50%) > gastrointestinal tract, heart
                                • Atypical form (HUS without coexisting disease) often due to dysregulation in alternative complement pathway
                                  • Diarrhea less common; ↑ mortality

                              IMAGING

                              • General Features

                                DIFFERENTIAL DIAGNOSIS

                                  PATHOLOGY

                                  • General Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              Selected References

                                              1. Cody EM et al: Hemolytic uremic syndrome. Pediatr Clin North Am. 66(1):235-46, 2019
                                              2. Herrmann J et al: Diffusion-weighted imaging of the kidneys in haemolytic uraemic syndrome. Eur Radiol. 27(11):4591-601, 2017
                                              3. Löbel U et al: Cerebral hemodynamics in patients with hemolytic uremic syndrome assessed by susceptibility weighted imaging and four-dimensional non-contrast MR angiography. PLoS One. 11(11):e0164863, 2016
                                              4. Reising A et al: Ultrasound findings in EHEC-associated hemolytic-uremic syndrome and their clinical relevance. Int Urol Nephrol. 48(4):561-70, 2016
                                              5. Keir LS: Shiga toxin associated hemolytic uremic syndrome. Hematol Oncol Clin North Am. 29(3):525-39, 2015
                                              6. Agarwal R et al: Posterior reversible encephalopathy and cerebral vasoconstriction in a patient with hemolytic uremic syndrome. Pediatr Neurol. 50(5):518-21, 2014
                                              7. Hofer J et al: Extra-renal manifestations of complement-mediated thrombotic microangiopathies. Front Pediatr. 2:97, 2014
                                              8. Kaplan BS et al: Current treatment of atypical hemolytic uremic syndrome. Intractable Rare Dis Res. 3(2):34-45, 2014
                                              9. Gitiaux C et al: Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab. Dev Med Child Neurol. 55(8):758-65, 2013
                                              10. Glatstein M et al: Timing and utility of ultrasound in diarrhea-associated hemolytic uremic syndrome: 7-year experience of a large tertiary care hospital. Clin Pediatr (Phila). 49(5):418-21, 2010
                                              11. Toldo I et al: Diffusion-weighted imaging findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol. 24(2):247-50, 2009
                                              12. Scholbach TM: Changes of renal flow volume in the hemolytic-uremic syndrome--color Doppler sonographic investigations. Pediatr Nephrol. 16(8):644-7, 2001